DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment emb and XPO6

DIOPT Version :9

Sequence 1:	NP_001303316.1	Gene:	emb / 34167	FlyBaseID:	FBgn0020497	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	NP_055986.1	Gene:	XPO6 / 23214	HGNCID:	19733	Length:	1125	Species:	Homo sapiens

Alignment Length:	1305	Identity:	231/1305 - (17%)
Similarity:	427/1305 - (32%)	Gaps:	458/1305 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SQKLDINLLDKIVEVVY--TAQGEQLRLAQSILTTLKEHPEAWTRVDSILEYSQNQRTKFYALQI 79
            |::..:..|:.::...:  ....|:.|..:.:|....:...||......|..::|.....|:|.:
Human     3 SEEASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTV 67

  Fly    80 LEEVIKTRWKVLPRNQCEGIKKYVVSLII---KTSSDPIVMEQNKVYLNKLNMILVHILKREWPR 141
            .|.:|...|..:|......|:..:..|::   ||.  |..:.      |||..::|.|.:::||.
Human    68 FENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTL--PYFIR------NKLCKVIVDIGRQDWPM 124

  Fly   142 NWETFISDIVGASKTNESLCMNNMVILKNLSEEVFDFSQGQITQTKAKHLKDTMCSEFSQIFTLC 206
            .:..|.::|:...::..:..: .:::||..|||: ...:..::..:.:.|:..:..:...:..|.
Human   125 FYHDFFTNILQLIQSPVTTPL-GLIMLKTTSEEL-ACPREDLSVARKEELRKLLLDQVQTVLGLL 187

  Fly   207 SFVLE-----NSMNAA-----------------------------------------LIHVTLET 225
            :.:||     :|:.||                                         :..:.||.
Human   188 TGILETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLNQPIPILDVESEYICSLALEC 252

  Fly   226 LLRFLNWIPLGYIFETQQIETLIFKF------------------------------LSVPMFRNV 260
            |....:||||.... |..:.|.||.|                              |.|     :
Human   253 LAHLFSWIPLSASI-TPSLLTTIFHFARFGCDIRARKMASVNGSSQNCVSGQERGRLGV-----L 311

  Fly   261 TLKCLSEIAGLTAA--NYDENFATLFKDTMVQLEQIVGQNMNMNHVFKHGSDTEQELVLNLAMFL 323
            .:.|::|:......  .::|....:|:.|...|::|...| |.:.|.....:.::..:.....||
Human   312 AMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKDN-NAHTVKSRLEELDESYIEKFTDFL 375

  Fly   324 CTFLKEHGKLVEDAK---YVDYLNQALMYLVMISEVEDVEVFKICLEYWNSLVEDLYNSEFFHPT 385
            ..|:..|.:.:|...   .|::|.....|..   .....|.:..||:.|...::.|
Human   376 RLFVSVHLRRIESYSQFPVVEFLTLLFKYTF---HQPTHEGYFSCLDIWTLFLDYL--------- 428

  Fly   386 LESTKRQQVYPRRRFYAPILSKVRFIMISRMAKPEEV----------LVVENEN----------- 429
                               .||::    ||:...|.|          |:.|..|
Human   429 -------------------TSKIK----SRLGDKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQL 470

  Fly   430 GEVVREFMKDTNSINLYKNMRETL-VFLTHLDSVDTDRIMTLKLLNQVN--------------GS 479
            .|:..|.:.|.......:.:|::| |....::.:.|....||..:.|.|              ||
Human   471 EELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLEVYLGLQQFIVTSGS 535

  Fly   480 ---------------EFSWKNLNTLCWAIGSISGAFC-EEDEKRF--LVTVIKDLLGLCEQKKGK 526
                           ..|.::|::|..|:|.::..|. :....||  .:||::.|:.:  ...|.
Human   536 GHRLNITAENDCRRLHCSLRDLSSLLQAVGRLAEYFIGDVFAARFNDALTVVERLVKV--TLYGS 598

  Fly   527 DNK---------AIIASNIMYVVGQYPRFLRA--HWKFLKTVVNKLFEFMHETHDGVQDMACDTF 580
            ..|         :::..:::.|..|....|:|  ||         |.::..|.|.
Human   599 QIKLYNIETAVPSVLKPDLIDVHAQSLAALQAYSHW---------LAQYCSEVHR---------- 644

  Fly   581 IKIAIKCRRYFVTIQPNEACTFIDEILTTMSSIICDLQPQQVHTFYEAVGYMISAQVDQVQQDVL 645
                 :..:.|||:           |.|||                :|:..:||.:|    ||.|
Human   645 -----QNTQQFVTL-----------ISTTM----------------DAITPLISTKV----QDKL 673

  Fly   646 IERYMQLPNQVWDDIISRASK-NVDFLKNMTAVKQ----------LGSILKTNVAACKALGHAYV 699
            :.....|       ::|.|:. ...||.::.||::          |..:.|..|..|:||.
Human   674 LLSACHL-------LVSLATTVRPVFLISIPAVQKVFNRITDASALRLVDKAQVLVCRALS---- 727

  Fly   700 IQLGRIYLDMLNVYKITSENIIQAIEVNGVNVNNQPLIKTMHVVKKETLNLISEWVSRSNDNQLV 764
                       |:..:...|:.:         |.|                  :|..||.::
Human   728 -----------NILLLPWPNLPE---------NEQ------------------QWPVRSINH--- 751

  Fly   765 MDNFIPPLLDAILLDYQRCKVPSAREPK---VLSAMAIIVHK-------LRQHITNEVPKIFDAV 819
                 ..|:.|:..||:..| |||..|:   .|....:|:|:       :.::|:.|..|.....
Human   752 -----ASLISALSRDYRNLK-PSAVAPQRKMPLDDTKLIIHQTLSVLEDIVENISGESTKSRQIC 810

  Fly   820 FECTLDMINKNFEDFP---------QHRLSFYELLQAVNAHCFKAF---LNIPPAQFKLVFDSVV 872
            ::...:.:..:...||         ...|||:..|       |:..   :.:|      ..:.::
Human   811 YQSLQESVQVSLALFPAFIHQSDVTDEMLSFFLTL-------FRGLRVQMGVP------FTEQII 862

  Fly   873 WAFKH--TMRNVAD-------MGLNIL---FKMLQNLDQHPG----------AAQSFYQTY---- 911
            ..|.:  |...:|:       .|..::   .|:||.:.|.||          .|....|.|
Human   863 QTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPSIIALCMEQVYPIIA 927

  Fly   912 ---FTDILMQIFSVVTDTSH---------------TAGLPNH---------AIILAYMFSLVENR 949
               ..|:..::|.::..|.|               ..|:...         ||:.|:..|.::
Human   928 ERPSPDVKAELFELLFRTLHHNWRYFFKSTVLASVQRGIAEEQMENEPQFSAIMQAFGQSFLQ-- 990

  Fly   950 KITVNLGPIPDNMIFIQE--YVASL-LKSAFTHLSDNQVKVFVTGLF----NLDENVQAFKEHLR 1007
                     ||..:|.|.  |:.:| .|....|     .|:|.|.:.    |:...|...|.|
Human   991 ---------PDIHLFKQNLFYLETLNTKQKLYH-----KKIFRTAMLFQFVNVLLQVLVHKSH-- 1039

  Fly  1008 DFL-----IQIREATGEDDSDL-------YLEEREAALAEEQS---NKHQMQRNIPGML-NPHEL 1056
            |.|     |.|......|....       :|...:...|.::|   ...:|.|::|... |.|.|
Human  1040 DLLQEEIGIAIYNMASVDFDGFFAAFLPEFLTSCDGVDANQKSVLGRNFKMDRDLPSFTQNVHRL 1104

  Fly  1057 PEDMQ 1061
            ..|::
Human  1105 VNDLR 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
emb	NP_001303316.1	CRM1	13..1023	CDD:227432	221/1254 (18%)
		IBN_N	43..109	CDD:197981	13/68 (19%)
		Xpo1	120..265	CDD:285575	35/220 (16%)
		CRM1_C	701..1015	CDD:285920	71/400 (18%)
XPO6	NP_055986.1	IBN_N	31..96	CDD:197981	13/64 (20%)
XPO6	NP_055986.1	Xpo1	103..253	CDD:369848	24/157 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900