Protein Alignment emb and xpo-1

DIOPT Version :10

• Sequence 1: NP_723391.2
• Gene: emb / 34167
• FlyBaseID: FBgn0020497
• Length: 1063
• Species: Drosophila melanogaster
• Sequence 2: NP_741567.1
• Gene: xpo-1 / 179160
• WormBaseID: WBGene00002078
• Length: 1080
• Species: Caenorhabditis elegans
• Alignment Length: 1086
• Identity: 538/1086 - (49%)
• Similarity: 762/1086 - (70%)
• Gaps: 33/1086 - (3%)

  Fly     1 MATMLTSDEAGKLLDFSQKLDINLLDKIVEVVYTAQGEQLRLAQSILTTLKEHPEAWTRVDSILE 65
            ::.|....||.:......::|:.|||::||::....|::...|..||.:|||..::||:||:||:
 Worm     3 VSAMEVLSEAKRQFAQGDRIDVTLLDQVVEIMNRMSGKEQAEANQILMSLKEERDSWTKVDAILQ 67

  Fly    66 YSQNQRTKFYALQILEEVIKTRWKVLPRNQCEGIKKYVVSLIIKTSSDPIVMEQNKVYLNKLNMI 130
            |||...:|::||||||.||:.:||.||:.|.||||.|:::.:.:.|||..||||:::.|:|||::
 Worm    68 YSQLNESKYFALQILETVIQHKWKSLPQVQREGIKSYIITKMFELSSDQSVMEQSQLLLHKLNLV 132

  Fly   131 LVHILKREWPRNWETFISDIVGASKTNESLCMNNMVILKNLSEEVFDFSQGQITQTKAKHLKDTM 195
            ||.|:|::||:.|.|||:|||.:||.||::|:|||.||..||||||||....:||.|.:|||...
 Worm   133 LVQIVKQDWPKAWPTFITDIVDSSKNNETVCINNMNILSLLSEEVFDFGSQNLTQAKEQHLKQQF 197

  Fly   196 CSEFSQIFTLCSFVLENSMNAALIHVTLETLLRFLNWIPLGYIFETQQIETLIFKFLSVPMFRNV 260
            |.:|.::||||..:||...:.:::..||:||.|||.|||:||:|||...|.|...|||:.::|.:
 Worm   198 CGQFQEVFTLCVSILEKCPSNSMVQATLKTLQRFLTWIPVGYVFETNITELLSENFLSLEVYRVI 262

  Fly   261 TLKCLSEIAGLTA----ANYDENFATLFKDTMVQLEQIVGQNMNMNHVFKHGSDTEQELVLNLAM 321
            .|:||:||:.:..    .:|||....:|..||..:.|::..::::..|:|..||.:|:|:.:||.
 Worm   263 ALQCLTEISQIQVETNDPSYDEKLVKMFCSTMRHISQVLSLDLDLAAVYKDASDQDQKLISSLAQ 327

  Fly   322 FLCTFLKEHGKLVE-------DAKYV-----DYLNQALMYLVMISEVEDVEVFKICLEYWNSLVE 374
            ||..|:|||..|:|       :||.:     ||   |:..|:.|:.:|::||||:||:.|..|..
 Worm   328 FLVAFIKEHVHLIEVTDEPLTEAKILMRESHDY---AIQLLLKITLIEEMEVFKVCLDCWCWLTA 389

  Fly   375 DLYN-SEFFHPTLESTKRQQV--YPRRRFYAPILSKVRFIMISRMAKPEEVLVVENENGEVVREF 436
            :||. ..|..|:.......||  :|||:.|...||::|..||||||||||||:|||:.||||||.
 Worm   390 ELYRICPFIQPSTLYGMMSQVREHPRRQLYREYLSQLRSTMISRMAKPEEVLIVENDQGEVVREM 454

  Fly   437 MKDTNSINLYKNMRETLVFLTHLDSVDTDRIMTLKLLNQVNGSEFSWKNLNTLCWAIGSISGAFC 501
            :|||:||.||:|||||||:|||||:.||:..||.||.:||||.||||||||.||||:|||||...
 Worm   455 VKDTDSIALYRNMRETLVYLTHLDNKDTEVKMTEKLASQVNGGEFSWKNLNRLCWAVGSISGTMV 519

  Fly   502 EEDEKRFLVTVIKDLLGLCEQKKGKDNKAIIASNIMYVVGQYPRFLRAHWKFLKTVVNKLFEFMH 566
            |||||||||.||:|||||||||:||||||:||||||||||||||||||||||||||:||||||||
 Worm   520 EEDEKRFLVLVIRDLLGLCEQKRGKDNKAVIASNIMYVVGQYPRFLRAHWKFLKTVINKLFEFMH 584

  Fly   567 ETHDGVQDMACDTFIKIAIKCRRYFVTIQPNEACTFIDEILTTMSSIICDLQPQQVHTFYEAVGY 631
            |||:|||||||||||||:|||:|:||.:||.|...|::|:|..::.|||||...|||.||||||:
 Worm   585 ETHEGVQDMACDTFIKISIKCKRHFVIVQPAENKPFVEEMLENLTGIICDLSHAQVHVFYEAVGH 649

  Fly   632 MISAQVDQVQQDVLIERYMQLPNQVWDDIISRASKNVDFLKNMTAVKQLGSILKTNVAACKALGH 696
            :||||:|...|:.||.:.|.:||:.|:|||:.||.|...|:....||.:.:||||||||||::|.
 Worm   650 IISAQIDGNLQEDLIMKLMDIPNRTWNDIIAAASTNDSVLEEPEMVKSVLNILKTNVAACKSIGS 714

  Fly   697 AYVIQLGRIYLDMLNVYKITSENIIQAIEVNGVNVNNQPLIKTMHVVKKETLNLISEWVSRSNDN 761
            ::|.|||.||.|:|::|||.||.:.:|:...|......||:|||..||:|.|.|:|.::|::.|.
 Worm   715 SFVTQLGNIYSDLLSLYKILSEKVSRAVTTAGEEALKNPLVKTMRAVKREILILLSTFISKNGDA 779

  Fly   762 QLVMDNFIPPLLDAILLDYQRCKVPSAREPKVLSAMAIIVHKLRQHITNEVPKIFDAVFECTLDM 826
            :|::|:.:|||.||:|.|||: .||.||||||||.::|:|.:|...:..:||.|..|||:|::||
 Worm   780 KLILDSIVPPLFDAVLFDYQK-NVPQAREPKVLSLLSILVTQLGSLLCPQVPSILSAVFQCSIDM 843

  Fly   827 INKNFEDFPQHRLSFYELLQAVNAHCFKAFLNIPPAQFKLVFDSVVWAFKHTMRNVADMGLNILF 891
            |||:.|.||:||.:|:||:.::...||..|:.:||.....|.|:|||||:|||||||::||:||.
 Worm   844 INKDMEAFPEHRTNFFELVLSLVQECFPVFMEMPPEDLGTVIDAVVWAFQHTMRNVAEIGLDILK 908

  Fly   892 KMLQNL-DQHPGAAQSFYQTYFTDILMQIFSVVTDTS--HTAGLPNHAIILAYMFSLVE-NRKIT 952
            ::|..: :|....||.||:.|:.|:|..:.:|..|:|  |.|||..:|.:|..:|...| :.|:.
 Worm   909 ELLARVSEQDDKIAQPFYKRYYIDLLKHVLAVACDSSQVHVAGLTYYAEVLCALFRAPEFSIKVP 973

  Fly   953 VN-LGPIPDNMIFIQEYVASLLKSAFTHLSDNQVKVFVTGLFNLDENVQAFKEHLRDFLIQIREA 1016
            :| ..|...|:.:|.|::....::.|.:::.:|:::.:.|.|:.:..:.:.:.|||||||||:|.
 Worm   974 LNDANPSQPNIDYIYEHIGGNFQAHFDNMNQDQIRIIIKGFFSFNTEISSMRNHLRDFLIQIKEH 1038

  Fly  1017 TGEDDSDLYLEEREAALAEEQSNKHQMQRNIPGMLNPHEL-PEDMQ 1061
            .|||.||||||||||.:.:.|    |.:|::||:|.|.|: .|||:
 Worm  1039 NGEDTSDLYLEEREAEIQQAQ----QRKRDVPGILKPDEVEDEDMR 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
emb	NP_723391.2	CRM1	13..1023	CDD:227432	514/1033 (50%)
xpo-1	NP_741567.1	CRM1	22..1062	CDD:227432	526/1047 (50%)