DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment emb and LOC100486598

DIOPT Version :9

Sequence 1:	NP_001303316.1	Gene:	emb / 34167	FlyBaseID:	FBgn0020497	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	XP_031757696.1	Gene:	LOC100486598 / 100486598	-ID:	-	Length:	1245	Species:	Xenopus tropicalis

Alignment Length:	1094	Identity:	221/1094 - (20%)
Similarity:	369/1094 - (33%)	Gaps:	279/1094 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 SQNQRTKFYALQILEEVIKTRWKVLPRNQCEGIKKYVVSLIIKTSSDPIVMEQNKVYLNKLNMIL 131
            |.:...:.:.|.:||.|||.||.|:..:....:|..|: |:|.....||:.|:..: .:.:..::
Frog   103 SHSPCVRHFGLHVLEHVIKFRWNVMSVDDRVFVKNSVM-LLISHGIHPILEEKGHI-KDVIARVV 165

  Fly   132 VHILKREWPRNWETFISDIVGASKTNESLCMNN---------MVILKNLSEEVFDFSQGQITQTK 187
            |.|:|||||.||...:         ||..|:.|         |.||..|:||:.......|.|.|
Frog   166 VEIIKREWPWNWPDMV---------NELACLGNFGDAQMELVMFILLRLAEEIGPLETRPICQPK 221

  Fly   188 AKH--LKDTMCSEFSQIFTLCSFVLENSMNAA-----LIHVTLETLLRFLNWIPLGYIF-ETQQI 244
            ..|  ||:.|...|:.:.|:....:.|..|..     :....|.||..::..:|...|. :...:
Frog   222 DLHELLKENMDKIFAFVVTILQRCVPNCQNLTQGQFRVAAAALRTLAGYIKCLPTRLIMADNCTL 286

  Fly   245 ETLIFKFLSVPMFRNVTLKCLSEIAGLTAAN-----YDEN--FATLFKD-------TMVQLEQIV 295
            ..|:...|:||..:....:||     |.|.|     .:|.  ...||::       |..||..
Frog   287 LWLLCVLLNVPELQMEAAECL-----LFAVNKKGLLLEERVPLLILFREDALRYILTAAQLAD-- 344

  Fly   296 GQNMNMNHVFKHGSDTEQELVLNLAMFLCTFLKEHGKLVEDAKYVDYLNQALMYLVMISEVEDVE 360
                         ||..||  .|..:     ||..|:::.|      |...|...|...||:..|
Frog   345 -------------SDPLQE--RNYVI-----LKMIGQILCD------LGNQLCAQVTAFEVKTPE 383

  Fly   361 VFKICLE-----------YWNSLVEDLYNSEFFHPTLESTKRQQVYPRRRFYAPILSKVRFIMIS 414
            .|...||           :..||..:::.:.|.|..|...      |:.....|.:.:...:.|.
Frog   384 NFDRYLEALLSLTRHPSLFLTSLAAEVWGTLFNHRVLSHD------PQLTAAIPDVLRAAMVSIV 442

  Fly   415 RMAKPEEVLVVENE-NGEVVREFMKDTNSINLY-----KNMRETLVFLTHLDSVDTDRIMTLKLL 473
            ::..|.    ::|. :.|..|....|....|.:     |.|...:..|..||:.....:.|..:.
Frog   443 KVGYPS----MDNSPSCEYSRMDFDDDIEFNTFFLSFRKQMGIVVRSLCRLDTRTVLHVATEWMR 503

  Fly   474 NQVNG---------------------SEFSWKNLNTLCWAIGSISGAFCEE-DEKRFLVTVIKDL 516
            :|::.                     |...|:.::..|   ..:....|.. ..:..|:|....|
Frog   504 HQLSAPLDPGPHNATSGEALCSPHSPSFLHWEAMSFFC---SEVFAPLCRPLSAEEVLLTQGVSL 565

  Fly   517 LGLCEQKKGKDNKAIIASNIMYVVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFI 581
            |......:.||  .:|.|.::..:.....|:|.....|..:|:||.     :..|..|..
Frog   566 LQQVISYETKD--PLIVSCVLTNLSTLLPFIRHGSDLLPLMVSKLL-----SAAGFADTD----- 618

  Fly   582 KIAIKCRRYFVTIQPNEACTFIDEILTTMSSIICDLQPQQVHTFYEAVGYMISAQVDQVQQDVLI 646
              |:|..|   |:..|     |....:.:...||...|..|...:|.:...|.|.:.|.|.....
Frog   619 --AVKVPR---TLLMN-----IRSCASALLQTICIRFPDLVGPHFEVLHTRIKALLGQEQLLADA 673

  Fly   647 ERYMQLPNQVWDDIISRASKNVDFLKNMTAVKQLGSILKTNVAACKALGHAYVIQLGRIYLDMLN 711
            ||...:...|   :.|...||.:..:::     |..:|:..|:...:.....|:.....::..|.
Frog   674 ERCALMGALV---LASNHFKNYNRQRSI-----LEELLQPAVSMLLSEEMQRVLSGPSEFISFLR 730

  Fly   712 VYKITSENIIQAIEVNGVNVNNQPLIKTMH----VVKKETLNLISEWVSRSN-------DNQLVM 765
            .....|||  |...|:|..::...|....:    .::|....:|.:......       |...::
Frog   731 ANNPGSEN--QEEGVDGGRLSYSKLCYCAYTFLAAIRKSRRPIIFKEAKAGGFVKGCTPDGVAML 793

  Fly   766 DNFIPPLLDAILLDYQRCKVPSARE-PKVLSAMAIIVHKLRQHITNEVP--------KIFDAVFE 821
            .|                  |.|.| .|||..:.:::..:......||.        |:.:....
Frog   794 QN------------------PCAGELLKVLDRLLVLIRTMNSLYLPEVMTKMAETSLKMAETSQS 840

  Fly   822 CTLDMINKNFEDFPQ-------HRLSFYELLQAVNAHCFKAFLNI-----PPAQFKLVFDSVVWA 874
            |.|:|.||:..|..|       ..::..|.||......:||...|     |             :
Frog   841 CELEMGNKSIMDCSQPIMGESGPPVTMPEQLQGPYNSLYKACCQILGKCGP-------------S 892

  Fly   875 FKHTMRNVADMGLNILFKMLQNLDQHPGAAQSFYQTYFTDILMQ----------IFSVVTDTSHT 929
            ..|...:|.|:...:|.....|||            |.:|:.::          ||...:....:
Frog   893 MPHEFYSVPDLASRLLSSAFTNLD------------YVSDLHLRHIVIDLVTPLIFYCPSKKYQS 945

  Fly   930 AGLPNHAIILAYMFSLVENRKITVNLGPIPDNMIFIQEYVAS---LLKSAFTHLSDNQVKVFVTG 991
            ..||....:|..::..:..:.:.:|           |...||   ||:.......|..|::
Frog   946 VALPILGPLLMSLYQRLSQKWLCIN-----------QRTTASEEDLLEEESESQDDLMVRL---- 995

  Fly   992 LFNLDENVQAFKEHLRDFLIQI----REATGEDDSDLYLEER--EAALAEEQSN 1039
               |...|..|        |.|    ...|.:.|:|..:..|  :|...||:.|
Frog   996 ---LSRTVVQF--------IYICCMASHTTYQSDADYRIAPRVEQAEADEEEEN 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
emb	NP_001303316.1	CRM1	13..1023	CDD:227432	215/1074 (20%)
		IBN_N	43..109	CDD:197981	13/41 (32%)
		Xpo1	120..265	CDD:285575	39/161 (24%)
		CRM1_C	701..1015	CDD:285920	62/362 (17%)
LOC100486598	XP_031757696.1	IBN_N	78..145	CDD:197981	14/42 (33%)
LOC100486598	XP_031757696.1	Xpo1	156..307	CDD:400614	39/160 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40069at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010