DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acp29AB and CLEC4A

DIOPT Version :9

Sequence 1:	NP_523512.2	Gene:	Acp29AB / 34162	FlyBaseID:	FBgn0015583	Length:	234	Species:	Drosophila melanogaster
Sequence 2:	NP_057268.1	Gene:	CLEC4A / 50856	HGNCID:	13257	Length:	237	Species:	Homo sapiens

Alignment Length:	175	Identity:	32/175 - (18%)
Similarity:	63/175 - (36%)	Gaps:	37/175 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 SSLLEFKAQMEIQLQPLKIIMRHHASNIKASNNIKMRRFEKVGSRHFHIEKNLMQTWFEAYVTCR 140
            |.|||.|...|:....|:.:.::.... :.:.:...:.::...|..:.|... ..:|.::...|.
Human    73 SQLLEKKTTKELVHTTLECVKKNMPVE-ETAWSCCPKNWKSFSSNCYFISTE-SASWQDSEKDCA 135

  Fly   141 KMNGHLANIQDEMELDGILA-LAPNNSY--------------WIDISKLVENGGTFVSTLTGREP 190
            :|..||..|..:.|.|.|.. |...::|              |:|.:...|: .||
Human   136 RMEAHLLVINTQEEQDFIFQNLQEESAYFVGLSDPEGQRHWQWVDQTPYNES-STF--------- 190

  Fly   191 FFVKWKSNQDTKKKNQCVYI----YAKEMSYDE--CFEKKSFVCQ 229
                |...:.:....:||.:    ..|...:::  |...:..||:
Human   191 ----WHPREPSDPNERCVVLNFRKSPKRWGWNDVNCLGPQRSVCE 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acp29AB	NP_523512.2	CLECT	121..229	CDD:214480	23/128 (18%)
CLEC4A	NP_057268.1	ITIM motif. /evidence=ECO:0000269\|PubMed:20530286	5..10
		CLECT_DC-SIGN_like	106..232	CDD:153060	25/141 (18%)
		Mannose binding. /evidence=ECO:0000269\|PubMed:27015765, ECO:0007744\|PDB:5B1X	195..197		0/1 (0%)
		N-acetyl-D-glucosamine binding. /evidence=ECO:0000269\|PubMed:27015765, ECO:0007744\|PDB:5B1X	207..209		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910