DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Acp29AB and CLEC12B

DIOPT Version :9

Sequence 1:	NP_523512.2	Gene:	Acp29AB / 34162	FlyBaseID:	FBgn0015583	Length:	234	Species:	Drosophila melanogaster
Sequence 2:	NP_001123470.1	Gene:	CLEC12B / 387837	HGNCID:	31966	Length:	276	Species:	Homo sapiens

Alignment Length:	247	Identity:	49/247 - (19%)
Similarity:	90/247 - (36%)	Gaps:	56/247 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLYLLALWNLW--------DLSGGQQDIPNGKATLPSPQTPQNTIDQIGINQNYWFTYNALKQNE 62
            |:.|:.|..|.        |::...:.:...:.|:...|  .|...|:|.:.|.......||..
Human    51 LMLLIGLVTLGMMFLQISNDINSDSEKLSQLQKTIQQQQ--DNLSQQLGNSNNLSMEEEFLKSQ- 112

  Fly    63 TLAIIDTMEMRIASSLLEFKAQMEIQLQPLKIIMRHHASNIKASNNIKMRRFEKVGSRHFHIEKN 127
                        .||:|:.:.||.|:|....||   |.|:.:.:...||.::.:  :..::...|
Human   113 ------------ISSVLKRQEQMAIKLCQELII---HTSDHRCNPCPKMWQWYQ--NSCYYFTTN 160

  Fly   128 LMQTWFEAYVTCRKMNGHLANIQDEMELDGILA--LAPNNSYWIDISKLVENGGTFVSTLTGREP 190
            ..:||..:...|...|..|..|....|.|.:::  |...:.:|:.:|          ...:||..
Human   161 EEKTWANSRKDCIDKNSTLVKIDSLEEKDFLMSQPLLMFSFFWLGLS----------WDSSGRSW 215

  Fly   191 FFVKWKSNQ-------DTKKKNQ------CVYIYAKEMSYDECFEKKSFVCQ 229
            |   |:...       .||:.:|      |.|.....:....|..:..::|:
Human   216 F---WEDGSVPSPSLFSTKELDQINGSKGCAYFQKGNIYISRCSAEIFWICE 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acp29AB	NP_523512.2	CLECT	121..229	CDD:214480	22/122 (18%)
CLEC12B	NP_001123470.1	ITIM motif	5..10
CLEC12B	NP_001123470.1	CLECT_NK_receptors_like	143..265	CDD:153063	25/137 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1201127at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920