DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13384 and SLC36A1

DIOPT Version :9

Sequence 1:	NP_723383.1	Gene:	CG13384 / 34160	FlyBaseID:	FBgn0032036	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_011535882.1	Gene:	SLC36A1 / 206358	HGNCID:	18761	Length:	482	Species:	Homo sapiens

Alignment Length:	497	Identity:	199/497 - (40%)
Similarity:	281/497 - (56%)	Gaps:	60/497 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 TERQPLLLQSDASDYEGSRGSAARPVRSSPPDNTLVNVHSEDSLAASGSGDDEIGSTDKSYNPTH 88
            |:|   |...|..||..:..|   |..|  |...|.|:.|..|....|..:.
Human     9 TQR---LRNEDYHDYSSTDVS---PEES--PSEGLNNLSSPGSYQRFGQSNS------------- 52

  Fly    89 HRDLEHPTSNFDTLVHLLKGNIGTGILAMPDAFKNAGLYVGLFGTMIMGAICTHCMHMLVNCSHE 153
                   |:.|.||:||||||||||:|.:|.|.||||:.:|....:|:|.:..|||.:||.|:|.
Human    53 -------TTWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHH 110

  Fly   154 LCRRFQQPSLDFSEVAYCSFESGPLG-LRRYSMLARRIVTTFLFITQIGFCCVYFLFVALNIKDV 217
            .|||..:..:|:.:......||.|.. ||.::...||:|..||.:||:|||||||:|:|.|.|.|
Human   111 FCRRLNKSFVDYGDTVMYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQV 175

  Fly   218 MD---------HYYK-------MPVQIYLLIMLGPMILLNLVRNLKYLTPVSLVAALLTVAGLAI 266
            ::         |..:       |..::|:|..|..::||..:|||:.|:..||:|.:..:..|.:
Human   176 IEAANGTTNNCHNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVM 240

  Fly   267 TFSYMLVDLPDVHTVKPVATWATLPLYFGTAIYAFEGIGVVLPLENNMRTPEDFGGTTGVLNTGM 331
            .:.:::..:||...:..||.|.|.||:|||||::|||||:||||||.|:.|..|   ..:|..||
Human   241 IYQFIVQRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKF---PLILYLGM 302

  Fly   332 VIVACLYTAVGFFGYLKYGEHVEGSITLNLPQGDTLSQLVRISMAVAIFLSYTLQFYVPVNIVEP 396
            |||..||.::|..|||::|.:::|||||||| ...|.|.|::..::.||.:|.||||||..|:.|
Human   303 VIVTILYISLGCLGYLQFGANIQGSITLNLP-NCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIP 366

  Fly   397 FVRSHFDTTRAKDLSATV----LRVVLVTFTFLLATCIPNLGSIISLVGAVSSSALALIAPPIIE 457
            |.     .:||.:....|    :|.|||..|.:||..||.|..:|||||:|||||||||.||::|
Human   367 FF-----VSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLE 426

  Fly   458 VITFYNVGYGRFNWMLWKDVLILIFGLCGFVFGTWASLAQIL 499
            |.|||:.|.....  ::||.||.|.|..|||.||:.:|.:::
Human   427 VTTFYSEGMSPLT--IFKDALISILGFVGFVVGTYEALYELI 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13384	NP_723383.1	SdaC	92..484	CDD:223884	177/412 (43%)
CG13384	NP_723383.1	SLC5-6-like_sbd	94..495	CDD:294310	183/421 (43%)
SLC36A1	XP_011535882.1	SLC5-6-like_sbd	53..459	CDD:294310	182/416 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158564
Domainoid	1	1.000	324	1.000	Domainoid score	I1198
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2472
Isobase	1	0.950	-	0	Normalized mean entropy	S2463
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm8520
orthoMCL	1	0.900	-	-		OOG6_100466
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R126
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750