Protein Alignment IDE and STE23

DIOPT Version :10

• Sequence 1: XP_016871679.2
• Gene: IDE / 3416
• HGNCID: 5381
• Length: 1061
• Species: Homo sapiens
• Sequence 2: NP_013493.2
• Gene: STE23 / 851105
• SGDID: S000004381
• Length: 1027
• Species: Saccharomyces cerevisiae
• Alignment Length: 1014
• Identity: 382/1014 - (37%)
• Similarity: 593/1014 - (58%)
• Gaps: 62/1014 - (6%)

Human    69 RGRPLGCFQK----KTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSS 129
            |.:|..|..:    ..|:..:|  .|.......|...|:|.||.:||.|.:|.|||.||..||::
Yeast    35 RFKPFTCLSRYYTTNPYNMTSN--FKTFNLDFLKPDLDERSYRFIELPNKLKALLIQDPKADKAA 97

Human   130 AALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFD 194
            |:|||:||:..||.|:.||:|||||:||:|::|:|.|||||.:||:|.|||||:|:.::|||:|:
Yeast    98 ASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFE 162

Human   195 VSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSK 259
            |:|:||.||||||:.||.||||::...|:|:|||:||::||:.||.||::||:|:..|.|||:.|
Yeast   163 VNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHK 227

Human   260 FGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKN 324
            |.|||..||.|.|.:.|::||.||||||..:||:|||.:|:||||.||.|::....||.:|.|..
Yeast   228 FSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNG 292

Human   325 VPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLL 389
            ..:|.:.|...|.|||:::.::.|:||::.|.::|.:||::::::|.|...|.|||||||.||||
Yeast   293 REVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWESKPPRILSHLIGHEGSGSLL 357

Human   390 SELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQ 454
            :.||..||.|.|..|....::|..||.:::|||:.||.|..|:|:.:||||:.|:...||:|:|.
Yeast   358 AHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHYRDVIVLIFQYIEMLKNSLPQKWIFN 422

Human   455 ECKDLNAVAFRFKDKERPRGYTSKIAGILH--YYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPEN 517
            |.:|::...|:||....|....|.:|..|.  |.|:..:| |..||.::.|||:....|.|.|||
Yeast   423 ELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIPVSRIL-AMGLLTKYEPDLLTQYTDALVPEN 486

Human   518 VRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFE---- 578
            .||.::|:|.|  ||..|:||||.||....|.::||..::..||....||..|||:.|||:
Yeast   487 SRVTLISRSLE--TDSAEKWYGTAYKVVDYPADLIKNMKSPGLNPALTLPRPNEFVSTNFKVDKI 549

Human   579 --ILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSRYIYADPLHCNMTYLFIRL 641
              |.||::     |.|:....:||||:|:||:|:.|:..:...|...:.:|..::..::.|:.:|
Yeast   550 DGIKPLDE-----PVLLLSDDVSKLWYKKDDRFWQPRGYIYLSFKLPHTHASIINSMLSTLYTQL 609

Human   642 LKDDLKEYTYAARLSGLSYGIASGMNAILLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKE 706
            ..|.||:..|.|..:.|..........:.::..|:|:|..|||.:.::.:.:||..:.||||:|:
Yeast   610 ANDALKDVQYDAACADLRISFNKTNQGLAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKD 674

Human   707 AYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALL 771
            ..:|.|.|...|.|:.....|...::.|.:|:..|..:..:.:|..:|..|||.:...::.|.|:
Yeast   675 KTIRHLKNLLYEVPYSQMSNYYNAIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLI 739

Human   772 HGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQL-------VRYREVQLPDRGWFVYQ---QRNE 826
            ||||..:.||.:     |:||     |.|:|:.:       .|.|...||....|.|:   :.::
Yeast   740 HGNIKHEEALEV-----DSLI-----KSLIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQ 794

Human   827 VHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFI 891
            ..|:| |:...|.|:.|...:....||.|:|.||||:||||||||||:|||.....:|...:|.:
Yeast   795 NVNSC-IQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRIL 858

Human   892 IQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQ 956
            ||||....|||.|:..|..|..:.:.||.||.|:||.:||....|.|.|.::.|.|:|...|...
Yeast   859 IQSEHTTPYLEWRINNFYETFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLG 923

Human   957 QYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA----REMDSCPVVGEFPCQ 1017
            .|||.....:...:..:||:.:|.||:..:.  :....|:.:|:.:    :|::          :
Yeast   924 DYNFTHRQKKAKLVANITKQQMIDFYENYIM--SENASKLILHLKSQVENKELN----------E 976

Human  1018 NDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINF 1056
            |:::.::   .|..::|:::..||..|.:.|:.:|..:|
Yeast   977 NELDTAK---YPTGQLIEDVGAFKSTLFVAPVRQPMKDF 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDE	XP_016871679.2	Ptr	96..1048	CDD:440648	373/973 (38%)
STE23	NP_013493.2	Ptr	66..1000	CDD:440648	372/967 (38%)