Protein Alignment IDE and CG10588

DIOPT Version :10

• Sequence 1: XP_016871679.2
• Gene: IDE / 3416
• HGNCID: 5381
• Length: 1061
• Species: Homo sapiens
• Sequence 2: NP_649271.1
• Gene: CG10588 / 40316
• FlyBaseID: FBgn0037037
• Length: 1058
• Species: Drosophila melanogaster
• Alignment Length: 1033
• Identity: 284/1033 - (27%)
• Similarity: 498/1033 - (48%)
• Gaps: 96/1033 - (9%)

Human    98 KSPEDKREYRGLELANGIKVLLISDPTTDKSS----------------------AALDVHIGSLS 140
            ||..|.:.||.|.|:||::.:||||...|:.|                      .|:.|.:||.|
  Fly    42 KSDGDSKLYRALTLSNGLRAMLISDSYIDEPSIHRASRESLNSSTENFNGKLAACAVLVGVGSFS 106

Human   141 DPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALD 205
            :|....||:||.|||:|:|::|:|.|||:..|:::..|.|||.|..|.|.:||::...||:..:|
  Fly   107 EPQQYQGLAHFVEHMIFMGSEKFPVENEFDSFVTKSGGFSNAHTENEETCFYFELDQTHLDRGMD 171

Human   206 RFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLET 270
            .|......||.......||.:||.||.|:..|.|..|..|:..:..:..:|...|..||..||
  Fly   172 LFMNLMKAPLMLPDAMSRERSAVQSEFEQTHMRDEVRRDQILASLASEGYPHGTFSWGNYKTL-- 234

Human   271 RPNQEGID---VRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEV---ENKNVPLPE 329
               :||:|   :.:||.||:..:|.||.|.|.:..:.|||:|..|:|:..:::   :..::.:.:
  Fly   235 ---KEGVDDSSLHKELHKFYRDHYGSNRMVVALQAQLSLDELEELLVRHCADIPTSQQNSIDVSQ 296

Human   330 FP-EHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELK 393
            .. :..|:::..|.::.:.|::|:..|.:|:.:|.::.:|:|.|..::..|||:||.|||.:.|:
  Fly   297 LNYQKAFRDQFYKDVFLVQPVEDVCKLELTWVLPPMKNFYRSKPDMFISQLIGYEGVGSLCAYLR 361

Human   394 SKGWVNTLVGGQKEGARG----FMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQ 454
            ...|..::|.|..|.:..    :..|.|.:.|:::|..|:::::...|.:::.:......:..::
  Fly   362 HHLWCISVVAGVAESSFDSNSIYSLFNICIYLSDDGFDHIDEVLEATFAWVKLIINSDQLQDSYK 426

Human   455 ECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVR 519
            |.:.:....|||:.:..|..:...|....:|.|.::|||...|..::....||::...:...|..
  Fly   427 ESQQIENNNFRFQIEPPPIDHVQSIVESFNYLPSKDVLTGPQLYFQYEESAIELLRQHMNKFNFN 491

Human   520 VAIVSK-SFE-GKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL 582
            :.|.|. .:| .:.|:.|.|:|||:|..::|.:....|:.:....:...|..|.|:.|:|:|..:
  Fly   492 IMISSYIPYEKNEYDQREPWFGTQFKTISMPPKWQTMWEQSATIKELHYPQPNPFVTTDFKIHWV 556

Human   583 EKEATPY-----PALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSRYIYADPLHCNMTYLFIRLL 642
            | ...|:     .|||::. :.:|||:||:.|.||...:|..|.:..:........:..||..|:
  Fly   557 E-SGKPHVSRSPKALIRND-LCELWFRQDNIFKLPDGYINLYFITPLVRESVKQYMLGVLFTYLV 619

Human   643 KDDLKEYTYAARLSGLSYGIASGMNAILLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEA 707
            :..:.|..|.|..:||:||:..|...:::.|.|||:|.|:|::.|:..|.|.|:|..:....|:.
  Fly   620 EFRMAEQLYPALEAGLTYGLYIGDKGLVMRVSGYNEKLPLLVEIILNMMQTIELDIGQVNAFKDL 684

Human   708 YMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLH 772
            ..|.:.|........:....|.:|..: .::.....|::||:|:..:|:|......:::::.|:.
  Fly   685 KKRQIYNALINGKSLNLDLRLSILENK-RFSMISKYESVDDITMDDIKSFKENFHKKMYVKGLIQ 748

Human   773 GNITKQAALGIMQMVEDTL-IEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQR-NEVHNNCGIEI 835
            ||.|:..|..:||.|.||. .|.......|.:.|     :|:|...:::..:. ||..:|..|..
  Fly   749 GNFTEDQATDLMQKVLDTYKSEKLDNLSALDNHL-----LQIPLGSYYLRAKTLNEDDSNTIITN 808

Human   836 YYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPH- 899
            |||...........::|...|:.||.||.|||:|||||.:....|...|:......|.:::..|
  Fly   809 YYQIGPSDLKMECIMDLVELIVEEPFFNQLRTQEQLGYSLGIHQRIGYGVLAFLITINTQETKHR 873

Human   900 --YLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDR 962
              |:|.|:|||...|.:.:..|::..|:...:.|...:......|..|..:.|.||::::|.|:|
  Fly   874 ADYVEQRIEAFRSRMAELVSQMSDTEFKNIRETLINGKKLGDTSLDEEVLRNWSEIVTKEYFFNR 938

Human   963 DNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHV--------------------------- 1000
            ..|::..|..|||||::.|..:.   |.....|:||.|
  Fly   939 IETQIQMLSHLTKEDVLNFLNDN---DKNNLRKLSVQVVGNHNQTSNSTAQASRSGSLSDLLDDV 1000

Human  1001 ---LAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHIN 1055
               :|.|.||..     |..:.|.|........|..|:::..||:.|.:|||...:.|
  Fly  1001 QDNMANETDSAK-----PMTDKIRLEFLGESDDPSSIKDIYAFKKDLYVFPLFNTNPN 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDE	XP_016871679.2	Ptr	96..1048	CDD:440648	280/1024 (27%)
CG10588	NP_649271.1	Ptr	38..996	CDD:440648	268/969 (28%)