Protein Alignment IDE and iph1

DIOPT Version :10

• Sequence 1: XP_016871679.2
• Gene: IDE / 3416
• HGNCID: 5381
• Length: 1061
• Species: Homo sapiens
• Sequence 2: NP_593966.1
• Gene: iph1 / 2542436
• PomBaseID: SPACUNK4.12C
• Length: 969
• Species: Schizosaccharomyces pombe
• Alignment Length: 978
• Identity: 363/978 - (37%)
• Similarity: 554/978 - (56%)
• Gaps: 36/978 - (3%)

Human    87 PAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHF 151
            |.::.|.|.......|.||||.::|.|.::|||:.||.||.:|||:||||||.|:|..:.||:||
pombe     5 PQVEVIVNGQVVPNLDDREYRLIKLENDLEVLLVRDPETDNASAAIDVHIGSQSNPRELLGLAHF 69

Human   152 CEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLF 216
            |||:||:||||||.||||.::|..|.|.|||:|:..:|||||:|||:.|.||||||||||:.|||
pombe    70 CEHLLFMGTKKYPDENEYRKYLESHNGISNAYTASNNTNYYFEVSHDALYGALDRFAQFFIDPLF 134

Human   217 DESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQ 281
            .|.|||||:.||||||.||:.:|:||.::|.....|||..||||.|||..||...|.:.|:||||
pombe   135 LEECKDREIRAVDSEHCKNLQSDSWRFWRLYSVLSNPKSVFSKFNTGNIETLGDVPKELGLDVRQ 199

Human   282 ELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKI 346
            |||||:..|||:|:|.:.::|||.||.|.:...:|||.::||.||:|:||:.|:.:..::::..:
pombe   200 ELLKFYDKYYSANIMKLVIIGREPLDVLQDWAAELFSPIKNKAVPIPKFPDPPYTDNEVRKICYV 264

Human   347 VPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARG 411
            .|:|::|.|.:.||||.....||..|..|:.||:||||.||.|:.|||.|...:|:.........
pombe   265 KPVKNLRRLDIVFPIPGQYHKYKCRPAEYVCHLLGHEGEGSYLAYLKSLGLATSLIAFNVSITED 329

Human   412 FMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYT 476
            ....:::..||||||...:.:|..:|:||:.|......:::|:|.:.::...|:.:.|.....|.
pombe   330 ADIIVVSTFLTEEGLTDYQRVIKILFEYIRLLDQTNAHKFLFEETRIMSEAQFKTRQKTPAYQYA 394

Human   477 SKIAGIL-HYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGT 540
            ..:|..| ..||.::||....:|.||.|..|:.|::.|||.|....:.:.|.|...|..|::||.
pombe   395 HVVASKLQREYPRDKVLYYSSVLTEFDPKGIQEVVESLRPNNFFAILAAHSIEKGLDNKEKFYGI 459

Human   541 QYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEAT----PYPALIKDTAMSKL 601
            .|..|.:..:.|....:...:.:..||..|||||.:.|:   ||:..    ..|.|:::....:|
pombe   460 DYGLEDLDSQFIDSLLHIKTSSELYLPLANEFIPWSLEV---EKQPVTTKLKVPNLVRNDKFVRL 521

Human   602 WFKQDDKFFLPKACLNFEFFSRYIYADPLHCNMTYLFIRLLKDDLKEYTYAARLSGLSYGIASGM 666
            |.|:||.|::|||.:...|.|......|.....|.|:.||::|.|.||:|.|.|:|||:.::...
pombe   522 WHKKDDTFWVPKANVFINFISPIARRSPKVSVSTTLYTRLIEDALGEYSYPASLAGLSFSLSPST 586

Human   667 NAILLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLL 731
            ..|:|.:.|:.||..:||:|::..|...::..:||||:|....:.|.::.|.:.:..:.:.|..|
pombe   587 RGIILCISGFTDKLHVLLEKVVAMMRDLKVHPQRFEILKNRLEQELKDYDALEAYHRSNHVLTWL 651

Human   732 MTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAH 796
            ....:|:..||:||:.||.:..:..||..||.:..:|:|:|||.|::.|..:::..: .||:
pombe   652 SEPHSWSNAELREAIKDVQVGDMSDFISDLLKQNFLESLVHGNYTEEDAKNLIESAQ-KLID--- 712

Human   797 TKPLLPSQLVRYREVQLPDRGWFVYQQ--RNEVHNNCGIEIYYQ-TDMQSTSENMFLELFCQIIS 858
            .||:..|||.|.|.:.:|:.|.::|:.  .|:...|..|....| :.:..........|..||:.
pombe   713 PKPVFASQLSRKRAIIVPEGGNYIYKTVVPNKEEKNSAIMYNLQISQLDDERSGALTRLARQIMK 777

Human   859 EPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEA 923
            ||.|:.||||||||||||:..|:......|...:|||:...|||||:.|.|...:....:|::|.
pombe   778 EPTFSILRTKEQLGYIVFTLVRQVTPFINLNIFVQSERSSTYLESRIRALLDQFKSEFLEMSDED 842

Human   924 FQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAV 988
            |.||..:|....|:|...|..|.:.||..|....|:|.|...:...:.|:||::...|:...:..
pombe   843 FSKHKSSLINFMLEKHTNLKEESSMYWLRICDGFYDFTRLEKQAEIVSTITKDEFYSFFINNIHY 907

Human   989 DAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPL----FPL 1049
            :.....|:||||:::.           |::::.     .:|...:|:|...||..:.|    |||
pombe   908 EGENTKKISVHVVSQR-----------CEDEVY-----EIPNVTIIENGNMFKESMTLSKAAFPL 956

Human  1050 VKP 1052
             ||
pombe   957 -KP 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDE	XP_016871679.2	Ptr	96..1048	CDD:440648	355/963 (37%)
iph1	NP_593966.1	Ptr	17..903	CDD:440648	343/892 (38%)