Protein Alignment IDE and C02G6.2

DIOPT Version :10

• Sequence 1: XP_016871679.2
• Gene: IDE / 3416
• HGNCID: 5381
• Length: 1061
• Species: Homo sapiens
• Sequence 2: NP_504531.2
• Gene: C02G6.2 / 182128
• WormBaseID: WBGene00015360
• Length: 816
• Species: Caenorhabditis elegans
• Alignment Length: 815
• Identity: 336/815 - (41%)
• Similarity: 489/815 - (60%)
• Gaps: 38/815 - (4%)

Human    86 NPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSH 150
            |..:||. |.|.|.|:|:||.|||||.||::|||:||||||||:.:|.|..|.|.||..:.||:|
 Worm     7 NIVLKRY-NSIVKGPQDERECRGLELTNGLRVLLVSDPTTDKSAVSLAVKAGHLMDPWELPGLAH 70

Human   151 FCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPL 215
            ||||||||||.|||.|||:::|||::|||.||.|..:||.|:|||..:.|.||||||.||||||.
 Worm    71 FCEHMLFLGTSKYPLENEFTKFLSDNAGSYNACTEPDHTYYHFDVKPDQLYGALDRFVQFFLCPQ 135

Human   216 FDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVR 280
            |.:|..:|||.||||||..|:.:|.||:.|::::...|.|...||.||||.||.....::||:.|
 Worm   136 FTKSATEREVCAVDSEHLSNLNSDYWRILQVDRSLSRPGHDNRKFCTGNKKTLLEDARKKGIEPR 200

Human   281 QELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKL-FSEVENKNVPLPEFPEHPFQEEHLKQLY 344
            ..||:|:..:||||:|..|::|:||||.|.:.:..| |..::||......:.|..:..:.|.:..
 Worm   201 DALLEFYKKWYSSNIMTCCIIGKESLDVLESYLRTLEFDAIQNKKAESKVWAEFQYGPDQLAKKI 265

Human   345 KIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGA 409
            .:|||||.:.:.:.||.|||...|.|.||||:.|||||:||||:.||||..||.::|....|..|
 Worm   266 DVVPIKDKKLVSIIFPFPDLNNEYLSQPGHYIAHLIGHKGPGSISSELKRLGWASSLKPESKTIA 330

Human   410 RGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRG 474
            .||.:|.:.:||:.|||.||::||..||.||..|::.|||:|:.:|..:|:|:.|||||:|....
 Worm   331 AGFGYFNVTMDLSTEGLEHVDEIIQLMFNYIGMLQSAGPQQWIHEELAELSAIEFRFKDREPLTK 395

Human   475 YTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSF---EGKTDRTEE 536
            ...|:|..|.|.|.|.:|::.|||.::.|:.|:.:|..|.|.|:.|.:|||.|   ||.|:  |.
 Worm   396 NAIKVARNLQYIPFEHILSSRYLLTKYNPERIKELLSTLTPSNMLVRVVSKKFKEQEGNTN--EP 458

Human   537 WYGTQYKQEAIPDEVIKKWQNA--DLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMS 599
            .|||:.|...|..|.:||::||  ..:....||.|||:|.|.|:..|.|.....:|.||.|...|
 Worm   459 VYGTEMKVTDISPEKMKKYENALKTSHHALHLPEKNEYIVTKFDQKPRESVKNEHPRLISDDGWS 523

Human   600 KLWFKQDDKFFLPKACLNFEFFSRYIYADPLHCNMTYLFIRLLKDDLKEYTYAARLSGLSYGIAS 664
            ::||||||::.:||......|.:..:..:|:...::.|::..|.|.|.|.||.|.::||.:.:.|
 Worm   524 RVWFKQDDEYNMPKQETKLAFTTPIVAQNPIMSLISSLWLWCLNDTLTEETYNAAIAGLKFQLES 588

Human   665 GMN----------------AILLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLN 713
            |.|                :|.|.|.||::|||:.:|.:.:.|..|:||..||:::.|:..|||.
 Worm   589 GHNGVHEQAGNWLDPERHASITLHVYGYDEKQPLFVKHLTKCMTNFKIDRTRFDVVFESLKRSLT 653

Human   714 NFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQ 778
            |....||:..:.|:..||:.|..|:|::|....|..||..::.|..:|....|:|..:|||.|::
 Worm   654 NHAFSQPYMLSKYFNELLVVEKVWSKEQLLAVCDSATLEDVQGFSKELFQAFHLELFVHGNSTEK 718

Human   779 AALGIMQMVEDTLIEHAHTKPLLPSQLVRY-------REVQLPDRGWFVYQQRNEVHNNCGIEIY 836
            .|:.:...:.|.|      |...|:..:.|       ||.||.:...::|:...:.|:...:|:.
 Worm   719 KAIQLSNELMDIL------KSAAPNSRLLYRNEHNPRREFQLNNGDEYIYRHLQKTHDAGCVEVT 777

Human   837 YQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQL 871
            ::..:|:|.:|....|..|:|.:|.|:||||||.|
 Worm   778 FKFGVQNTYDNALAGLISQLIRQPAFSTLRTKESL 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDE	XP_016871679.2	Ptr	96..1048	CDD:440648	332/805 (41%)
C02G6.2	NP_504531.2	Ptr	14..812	CDD:440648	332/805 (41%)