Protein Alignment AlaRS and alaS

DIOPT Version :10

• Sequence 1: NP_523511.2
• Gene: AlaRS / 34156
• FlyBaseID: FBgn0027094
• Length: 966
• Species: Drosophila melanogaster
• Sequence 2: NP_417177.1
• Gene: alaS / 947175
• ECOCYCID: EG10034
• Length: 876
• Species: Escherichia coli
• Alignment Length: 992
• Identity: 369/992 - (37%)
• Similarity: 522/992 - (52%)
• Gaps: 157/992 - (15%)

  Fly     8 EVRNAYLDFFKEQKHIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSKWVRVANTQ 72
            |:|.|:||||..:.|..|.|||.:|.:||||||.||||||||.:|||....|     :.|...:|
E. coli     7 EIRQAFLDFFHSKGHQVVASSSLVPHNDPTLLFTNAGMNQFKDVFLGLDKRN-----YSRATTSQ 66

  Fly    73 KCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLTQR--LALPKDRLYVT 135
            :|:|||||||||::||....||||||||||:|||||||.:...:|||.||..  .||||:||:||
E. coli    67 RCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKHDAIQFAWELLTSEKWFALPKERLWVT 131

  Fly   136 YFGGDAASGLEPDLECKQMW-LDLGLKPEHILP-GSMK------DNFWEMGETGPCGPCSEL--- 189
            .:        |.|.|..::| .::|:..|.|:. |..|      ||||:||:|||||||:|:
E. coli   132 VY--------ESDDEAYEIWEKEVGIPRERIIRIGDNKGAPYASDNFWQMGDTGPCGPCTEIFYD 188

  Fly   190 HFDRIGGRSVPELVNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKR 254
            |.|.|.| ..|.....|....:||||:||:|:||::||:::.|||..:|.|||.||:.:|:|:..
E. coli   189 HGDHIWG-GPPGSPEEDGDRYIEIWNIVFMQFNRQADGTMEPLPKPSVDTGMGLERIAAVLQHVN 252

  Fly   255 SNYDTDLFVPLFDAIQAGTGAPPYQGRVGADDVDGIDMAYRVLADHARTITIALADGGTPDNTGR 319
            ||||.|||..|..|:...|||           .|..:.:.||:|||.|:....:|||..|.|..|
E. coli   253 SNYDIDLFRTLIQAVAKVTGA-----------TDLSNKSLRVIADHIRSCAFLIADGVMPSNENR 306

  Fly   320 GYVLRRILRRAVRYATEKLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKT 384
            |||||||:|||||:. ..|.||..||..||..::|::|.|..::|:....:..::..||.||.:|
E. coli   307 GYVLRRIIRRAVRHG-NMLGAKETFFYKLVGPLIDVMGSAGEDLKRQQAQVEQVLKTEEEQFART 370

  Fly   385 LTRGRNLLNRTIEKLGNQTTIPGDVAWRLYDTYGFPVDLTQLMAEEKSLKIDMDGYEAAKHNSYV 449
            |.||..||:..:.||... |:.|:.|:|||||||||||||..:..|:::|:|..|:|||..
E. coli   371 LERGLALLDEELAKLSGD-TLDGETAFRLYDTYGFPVDLTADVCRERNIKVDEAGFEAAME---- 430

  Fly   450 LSQGKGASKIEEINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSAYNYGVCNSKIVALRFE 514
             .|.:.|.:......|.:|:.::.      :...||            .|::...|.|:.||..:
E. coli   431 -EQRRRAREASGFGADYNAMIRVD------SASEFK------------GYDHLELNGKVTALFVD 476

  Fly   515 NQFVNEITSGQKAGIVLDKTNFYAESGGQIYDQGALVKVNDEANEFLVDRVYNRGGYILHIG-VV 578
            .:.|:.|.:||:|.:|||:|.||||||||:.|:|.|...|   ..|.|:.....|..|.||| :.
E. coli   477 GKAVDAINAGQEAVVVLDQTPFYAESGGQVGDKGELKGAN---FSFAVEDTQKYGQAIGHIGKLA 538

  Fly   579 EGTLKVGDELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAA 643
            .|:|||||.::..:|..||.....||||||.::..|.||||....||||||..:.|||||:...|
E. coli   539 AGSLKVGDAVQADVDEARRARIRLNHSATHLMHAALRQVLGTHVSQKGSLVNDKVLRFDFSHNEA 603

  Fly   644 MTIEQVSKTEQLTKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPDPVRVISFGVPVDELEQ 708
            |..|::...|.|....:.:|:||......|. |.|.:|..::|.|.|.:.|||:|.|
E. coli   604 MKPEEIRAVEDLVNTQIRRNLPIETNIMDLE-AAKAKGAMALFGEKYDERVRVLSMG-------- 659

  Fly   709 NPDSEAGEQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSEAFEQE 773
                    ..|.|.|||||..|:|.|..|.|.||...|.|:|||.|:||..|:
E. coli   660 --------DFSTELCGGTHASRTGDIGLFRIISESGTAAGVRRIEAVTGEGAI------------ 704

  Fly   774 IVRLKATIDNDKSGKDSKSHVKEIVELTEQISHATIPYVKKDEMRNLLKGLKKTLDDKERALRAA 838
                 ||:..|                ::::|          |:.:||||....|.||.|
E. coli   705 -----ATVHAD----------------SDRLS----------EVAHLLKGDSNNLADKVR----- 733

  Fly   839 VSVTVVERAKTL----------CEANPNATVLVEQLEAFNNTKALDAAL-----KQVRSQLPD-- 886
               :|:||.:.|          ..|..:|.:..:.::. |..|.|.:.|     |.:|:.:.|
E. coli   734 ---SVLERTRQLEKELQQLKEQAAAQESANLSSKAIDV-NGVKLLVSELSGVEPKMLRTMVDDLK 794

  Fly   887 ---AAAMFLSVDADSKKIFCLSSVPKSAVEKGLKANEWVQHVSATLGGKGGGKPESAQASGTNYE 948
               .:.:.:.......|:..::.|.|...:: :||.|.:..|:..:||||||:|:.|||.||:..
E. coli   795 NQLGSTIIVLATVVEGKVSLIAGVSKDVTDR-VKAGELIGMVAQQVGGKGGGRPDMAQAGGTDAA 858

  Fly   949 KVDEIVQLASKFAQSKL 965
            .:...:.....:..:||
E. coli   859 ALPAALASVKGWVSAKL 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	367/988 (37%)
alaS	NP_417177.1	AlaS	3..875	CDD:439784	367/990 (37%)