DRSC/TRiP Functional Genomics Resources

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Protein Alignment AlaRS and CDC23

DIOPT Version :9

Sequence 1:NP_523511.2 Gene:AlaRS / 34156 FlyBaseID:FBgn0027094 Length:966 Species:Drosophila melanogaster
Sequence 2:NP_004652.2 Gene:CDC23 / 8697 HGNCID:1724 Length:597 Species:Homo sapiens


Alignment Length:645 Identity:123/645 - (19%)
Similarity:212/645 - (32%) Gaps:239/645 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   362 EVKKDPQHIIDIINEEELQFLKTLTRGRNLLNRTIEKLGNQTTIPGDVAWRLYDTYGFP-VDLTQ 425
            |:||            :|..:..|||.|.||:.:              .|.....:..| :.|.:
Human    31 EIKK------------QLLLIAGLTRERGLLHSS--------------KWSAELAFSLPALPLAE 69

  Fly   426 L-----MAEEKSLKIDMDGYEAAKHNSYVLSQGKGASKIEEINLDVHAISQLQEQGVPPTNDTFK 485
            |     :.||.:.  |||.|..||  :|.        .::|.:...|.:     .|.......|.
Human    70 LQPPPPITEEDAQ--DMDAYTLAK--AYF--------DVKEYDRAAHFL-----HGCNSKKAYFL 117

  Fly   486 YKYEA-VSDER----DSAYNYG------VCNSKIVALRFENQFVNEITSGQKA-----------G 528
            |.|.. :|.|:    ::..:.|      |.|..:..||.      |::...:|           |
Human   118 YMYSRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRV------ELSKKHQARELDGFGLYLYG 176

  Fly   529 IVLDKTNFYAESGGQIYDQGALVKVNDEANEFLVDRVYNRGGYILHIGV-VEGTLKVGD-ELELH 591
            :||.|.:...|:          :.|..||...|.          ||.|. :|....:.| |:...
Human   177 VVLRKLDLVKEA----------IDVFVEATHVLP----------LHWGAWLELCNLITDKEMLKF 221

  Fly   592 IDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFN-SKAAMTIEQVSKTEQL 655
            :.:...|  ||.....|....  ||::.:..::..:|:       |.. ||::..:.|::     
Human   222 LSLPDTW--MKEFFLAHIYTE--LQLIEEALQKYQNLI-------DVGFSKSSYIVSQIA----- 270

  Fly   656 TKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEV-YPDPVRVISFGVPVDELEQNPDSEAG---- 715
               :.|.|:            :.|....|:|:|: ..||.|:           :|.|:.:.    
Human   271 ---VAYHNI------------RDIDKALSIFNELRKQDPYRI-----------ENMDTFSNLLYV 309

  Fly   716 -----------------EQTSVEFC---GGTHLRRSGHIMDFVISSEEAIAKGIRRIVA--LTGP 758
                             ::..||.|   |..:..||.| ....:..:.|:....|.:.|  |.|.
Human   310 RSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQH-EKAALYFQRALKLNPRYLGAWTLMGH 373

  Fly   759 EALKALKKSEAFE----------------------QEIVRL---------KATIDNDKSGKDSKS 792
            |.::....|.|.:                      .||:::         :|   :.....||:.
Human   374 EYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRA---HQLRPNDSRM 435

  Fly   793 HVK--EIVELTEQISHATIPY--------VKKDEMRNLLKGLKKTLDDKERALRAAVSV------ 841
            .|.  |..|...|:..|...|        |:|..:..|.| |.:.|.:.|:|.:..:..      
Human   436 LVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAK-LHEQLTESEQAAQCYIKYIQDIYS 499

  Fly   842 --TVVERAKT------------LCEANPNATVLVEQLEAFNNT----KALDAALKQVRSQ 883
              .:||..:.            .|:....|:...::..|||:|    |||...:.|:|:|
Human   500 CGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRNQ 559

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AlaRSNP_523511.2 PLN02900 5..963 CDD:215487 123/645 (19%)
AlaRS_core 6..253 CDD:238360
tRNA_SAD 529..>626 CDD:298782 20/98 (20%)
tRNA_SAD 694..752 CDD:285247 12/81 (15%)
DHHA1 888..957 CDD:280440
CDC23NP_004652.2 TPR 1 27..63 11/57 (19%)
ANAPC8 45..148 CDD:397937 26/133 (20%)
TPR 2 73..112 12/55 (22%)
TPR 3 114..144 6/29 (21%)
TPR 4 169..200 8/40 (20%)
YciM 214..>491 CDD:225504 58/323 (18%)
TPR 5 229..259 7/38 (18%)
TPR 6 263..293 7/49 (14%)
TPR 7 297..327 2/40 (5%)
TPR 8 331..361 8/30 (27%)
TPR repeat 331..359 CDD:276809 8/28 (29%)
TPR 9 366..395 6/28 (21%)
TPR repeat 367..393 CDD:276809 6/25 (24%)
TPR repeat 398..428 CDD:276809 3/32 (9%)
TPR 10 400..432 3/34 (9%)
TPR 11 433..466 7/32 (22%)
TPR repeat 433..461 CDD:276809 7/27 (26%)
TPR repeat 467..495 CDD:276809 7/28 (25%)
TPR 12 468..500 6/32 (19%)
TPR repeat 501..536 CDD:276809 4/34 (12%)
TPR 13 504..540 5/35 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0013
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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