Protein Alignment AlaRS and CDC23

DIOPT Version :10

• Sequence 1: NP_523511.2
• Gene: AlaRS / 34156
• FlyBaseID: FBgn0027094
• Length: 966
• Species: Drosophila melanogaster
• Sequence 2: NP_012036.1
• Gene: CDC23 / 856571
• SGDID: S000001209
• Length: 626
• Species: Saccharomyces cerevisiae
• Alignment Length: 679
• Identity: 119/679 - (17%)
• Similarity: 227/679 - (33%)
• Gaps: 232/679 - (34%)

  Fly   373 IINEEELQFLKTLTRGRNLLNRTIEKLGNQTTIPGDVAWRLYDT------------YGFPVDLTQ 425
            ||::..:|..|..|.    |:|                |:||.:            ....||.|.
Yeast     9 IIHDIRIQLRKAATE----LSR----------------WKLYGSSKWAAEALAGLAEAIDVDQTH 53

  Fly   426 LMAEEKSLK-----------IDMDGY--EAAKHNSYVLSQGKGASKIEEINLDVHAI-------- 469
            .:|:|..|:           |..:|:  ...:::.|:|  |......:|.:..|..:
Yeast    54 SLADESPLRNKQGVPKQMFEIPQNGFGLSETEYDLYLL--GSTLFDAKEFDRCVFFLKDVTNPYL 116

  Fly   470 ---------------SQLQEQGVPPTNDTFKYKYEAVSDERDSAYNYGV-------CNSKIVALR 512
                           ||...:.:..|.......|.|..| .|.:.|..:       .|.|:|:..
Yeast   117 KFLKLYSKFLSWDKKSQESMENILTTGKFTDEMYRANKD-GDGSGNEDINQSGHQRANLKMVSNE 180

  Fly   513 FENQFVNEITSGQKAGIVLDKTNFYAESGGQIYDQGALVKVNDEANEFLVDRVYNRGGYILHIGV 577
            .|:|  :.|:|      :|.:.|.:.||    |:    :|::|:..:..:..:|...|.|
Yeast   181 HESQ--SNISS------ILKEINTFLES----YE----IKIDDDEADLGLALLYYLRGVI----- 224

  Fly   578 VEGTLKVGDELELHIDVERRWLTMKNHSATHALN-HCLLQVLGKDTEQK--GSLVVPEKLRFDFN 639
                      |:...::.:...:.....:.::.| .|.|:::  |..||  .:|::...|..:|.
Yeast   225 ----------LKQEKNISKAMSSFLKSLSCYSFNWSCWLELM--DCLQKVDDALLLNNYLYQNFQ 277

  Fly   640 SKAAMTIEQVSKTEQLTKEMVYKNVPIYAKESKLALAKKIRG-LRSVFD------EVYPDPVRVI 697
            .|.:..:     ..|.|.|.   |:.|  |..||.:.:::.| |...|:      :|:|:...:.
Yeast   278 FKFSENL-----GSQRTIEF---NIMI--KFFKLKVFEELNGQLEDYFEDLEFLLQVFPNFTFLK 332

  Fly   698 SFGVPVDELEQNPDSEAGEQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALK 762
            ::...:                           |.:.:|:|.:..
Yeast   333 AYNATI---------------------------SYNNLDYVTAES-------------------- 350

  Fly   763 ALKKSEAFEQEIVRLKATIDNDKSGKDSKSHVKEIVELTEQISHATIPYVKKDEMRN----LLKG 823
              :..:..:|:..||     ||   .::.|::..:::...::::......:.|..|.    ::..
Yeast   351 --RFDDIVKQDPYRL-----ND---LETYSNILYVMQKNSKLAYLAQFVSQIDRFRPETCCIIAN 405

  Fly   824 LKKTLDDKERALRAAVSVTVVERAKTLCEANPNATVLV--EQLEAFNNTKALDAALKQVRSQLPD 886
            ......:.|:      |:....||.||.:...||..|:  |.:|..|:..|::...:.|.....|
Yeast   406 YYSARQEHEK------SIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRD 464

  Fly   887 AAAMF--------LSVDADSKKIFCLSSVPKSAVEKGLKANEWVQHVSATLG---GKGGGKPE-- 938
            ..|.|        |.:...|...|          :|......|.:.:...||   .|.|.|.|
Yeast   465 FKAWFGLGQAYALLDMHLYSLYYF----------QKACTLKPWDRRIWQVLGECYSKTGNKVEAI 519

  Fly   939 -----SAQASGTNYEKVDEIVQLASKFAQ 962
                 |.:||.|    ||:...:..:.||
Yeast   520 KCYKRSIKASQT----VDQNTSIYYRLAQ 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	119/679 (18%)
CDC23	NP_012036.1	ANAPC8	12..144	CDD:427675	24/153 (16%)
		BepA	306..427	CDD:443813	21/183 (11%)
		TPR	391..>554	CDD:440225	38/174 (22%)
		TPR repeat	397..425	CDD:276809	4/33 (12%)
		TPR repeat	433..459	CDD:276809	6/25 (24%)
		TPR repeat	464..494	CDD:276809	7/39 (18%)
		TPR repeat	499..527	CDD:276809	7/27 (26%)
		TPR repeat	536..564	CDD:276809	2/9 (22%)