DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AlaRS and ALATS

DIOPT Version :9

Sequence 1:	NP_523511.2	Gene:	AlaRS / 34156	FlyBaseID:	FBgn0027094	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_001185186.2	Gene:	ALATS / 841442	AraportID:	AT1G50200	Length:	1011	Species:	Arabidopsis thaliana

Alignment Length:	989	Identity:	458/989 - (46%)
Similarity:	608/989 - (61%)	Gaps:	66/989 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AKEVRNAYLDFFKEQKHIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSKWVRVAN 70
            ||.||:.|:|||:.:.|.:..||..:|.:|||||||||||||:|||||||||||:|:||..|..|
plant    61 AKRVRDTYVDFFRGKGHKFWPSSPVVPHNDPTLLFANAGMNQYKPIFLGTADPNTELSKLSRACN 125

  Fly    71 TQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLTQRLALPKDRLYVT 135
            ||||||||||||||||||||.|||||||||||||||||||||...||||.||:...||.||:|.|
plant   126 TQKCIRAGGKHNDLDDVGKDTYHHTFFEMLGNWSFGDYFKKEAIEWAWELLTKVYGLPTDRIYAT 190

  Fly   136 YFGGDAASGLEPDLECKQMWLDLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDRIGGRSVP 200
            |||||..:||:||.|.:.:||.: |....:||...||||||||:|||||||:|:|:||||.|...
plant   191 YFGGDEKAGLQPDNEARDIWLKV-LPSGRVLPFGCKDNFWEMGDTGPCGPCTEIHYDRIGNRDAA 254

  Fly   201 ELVNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYDTDLFVPL 265
            .|||.|||..||||||||||:|||||||||.||.||:|.|||||||.||:|||.||||||:|:|:
plant   255 SLVNNDDPTCLEIWNLVFIQFNRESDGSLKPLPAKHVDTGMGFERLTSVLQNKMSNYDTDVFMPI 319

  Fly   266 FDAIQAGTGAPPYQGRVGADDVDGIDMAYRVLADHARTITIALADGGTPDNTGRGYVLRRILRRA 330
            ||.||..|||.||.|:||.:|||.:||||||:|||.||::.|:|||..|.|.||.||||||||||
plant   320 FDDIQKATGARPYSGKVGPEDVDRVDMAYRVVADHIRTLSFAIADGSRPGNEGREYVLRRILRRA 384

  Fly   331 VRYATEKLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGRNLLNRT 395
            |||..|.|.|:.|||..||::|:.::||.|.|:|:..:.|.|||.|||..|.|||.:|
plant   385 VRYGKEILKAEEGFFNGLVSSVIRVMGDVFTELKEHEKKITDIIKEEEASFCKTLAKG------- 442

  Fly   396 IEKL--------GNQTTIPGDVAWRLYDTYGFPVDLTQLMAEEKSLKIDMDGYEAA------KHN 446
            |||.        ||  |:.||.|:.|:||||||:|||||||||:.|.:|:||:..|      :..
plant   443 IEKFRKAGQAVQGN--TLSGDDAFILWDTYGFPLDLTQLMAEERGLLVDVDGFNKAMEEARERSR 505

  Fly   447 SYVLSQGKGASKIEEINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSAYNYGVCNSKIVAL 511
            |....|..||     |.:|..|.|.|.:.||..|:|:|||.:  ..|.          .|::.|:
plant   506 SAQNKQAGGA-----IVMDADATSTLHKAGVSATDDSFKYIW--FQDH----------ESELKAI 553

  Fly   512 RFENQFVNEITSGQKAGIVLDKTNFYAESGGQIYDQGALVKVNDEANEFLVDRVYNRGGYILHIG 576
            ...:.|:....:....|:||..|:||||.||||:|.|.   :......|.|..|...||::||||
plant   554 YTGSTFLESSAASDNVGLVLGSTSFYAEQGGQIFDTGL---IEGSFGTFNVCNVQIFGGFVLHIG 615

  Fly   577 VVE---GTLKVGDELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDF 638
            .:.   |.:.|||::...:|.|||.|...||:.||.||:.|.:|||...:||||:|:||||||||
plant   616 YLSKETGEVSVGDKVICKVDYERRKLIAPNHTCTHMLNYALKEVLGDHIDQKGSIVLPEKLRFDF 680

  Fly   639 NSKAAMTIEQVSKTEQLTKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPDPVRVISFGVPV 703
            :....:..|.:.:.|.:..:.:...:.:::||:.|:.||:|:|||:||.|||||||||:|.|..|
plant   681 SHGKPVDPEDLRRIESIVNKQIKDELDVFSKEAVLSEAKRIKGLRAVFGEVYPDPVRVVSIGRKV 745

  Fly   704 DELEQNPDSEAGEQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSE 768
            ::|..:|::......|.|||||||:..:.....|.:.|||.|||||||:.|:|...|..||..:.
plant   746 EDLLADPENNEWSLLSSEFCGGTHITNTREAKAFALLSEEGIAKGIRRVTAVTTECAFDALNAAS 810

  Fly   769 AFEQEIVRLKATIDNDKSGKDSKSHVKEIVELTEQISHATIPYVKKDEMRNLLKGLK-----KTL 828
            ..|:|:        .|.|..:..:..|::..|..::..|.||..||.::|..:..|:     ...
plant   811 LLEREV--------EDASRAEGSALEKKVSALKSRVDAAIIPAAKKADIRTKIASLQVISSFSLT 867

  Fly   829 DDKERALRAAVSVTVVERAKTLCEANPNA-----TVLVEQLEAFNNTKALDAALKQVRSQLPDAA 888
            ::..:|.:......:.:..|...||..:|     |..:.||:...:..|:..|:.:|..:...:.
plant   868 NEVRKAQKKIAEQNLKKSVKLATEAAESAASDGKTFCIIQLDVGLDAAAVREAVSKVMEKKGMSI 932

  Fly   889 AMFLSVDADSKKIFCLSSVPKSAVEKGLKANEWVQHVSATLGGK-GGGKPESAQASGTNYEKVDE 952
            .:|.:.::.:|.:.|.....||...|.|...||:......|.|: |.||...|...||:..:|..
plant   933 MVFSTDESTNKAVVCAGVPEKSDQFKPLDVTEWLTTALGPLKGRCGKGKGGLASGQGTDASQVQA 997

  Fly   953 IVQLASKFAQSKLS 966
            .:.:||.||..||:
plant   998 ALDMASSFASMKLN 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	456/984 (46%)
		AlaRS_core	6..253	CDD:238360	171/246 (70%)
		tRNA_SAD	529..>626	CDD:298782	42/99 (42%)
		tRNA_SAD	694..752	CDD:285247	26/57 (46%)
		DHHA1	888..957	CDD:280440	18/69 (26%)
ALATS	NP_001185186.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	633	1.000	Domainoid score	I32
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1213
Inparanoid	1	1.050	836	1.000	Inparanoid score	I72
OMA	1	1.010	-	-		QHG60684
OrthoDB	1	1.010	-	-		D129373at2759
OrthoFinder	1	1.000	-	-		FOG0001295
OrthoInspector	1	1.000	-	-		oto3548
orthoMCL	1	0.900	-	-		OOG6_100414
Panther	1	1.100	-	-	LDO	PTHR11777
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X999
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840