DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AlaRS and EMB1030

DIOPT Version :9

Sequence 1:	NP_523511.2	Gene:	AlaRS / 34156	FlyBaseID:	FBgn0027094	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_001330952.1	Gene:	EMB1030 / 832343	AraportID:	AT5G22800	Length:	1003	Species:	Arabidopsis thaliana

Alignment Length:	1007	Identity:	327/1007 - (32%)
Similarity:	498/1007 - (49%)	Gaps:	150/1007 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KLLTAKEVRNAYLDFFKEQKHIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSKWV 66
            |.::...:|..:|:||..:.|..:.|||.:| :|||:|...|||.||||||||      ::.:.|
plant   101 KDVSGDSIRRRFLEFFASRGHKVLPSSSLVP-EDPTVLLTIAGMLQFKPIFLG------KVPREV 158

  Fly    67 RVANT-QKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLTQRLALPKD 130
            ..|.| |:|||.    |||::|||...||||||||||:|||||||||...||||..|....||.:
plant   159 PCATTAQRCIRT----NDLENVGKTARHHTFFEMLGNFSFGDYFKKEAIKWAWELSTIEFGLPAN 219

  Fly   131 RLYVTYFGGDAASGLEPDLECKQMWL-DLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDRI 194
            |::|:.:        |.|.|..::|. ::|:..|.|......||||..|.||||||||||::|..
plant   220 RVWVSIY--------EDDDEAFEIWKNEVGVSVERIKRMGEADNFWTSGPTGPCGPCSELYYDFY 276

  Fly   195 GGRSVPELVNM-DDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYD 258
            ..|...|.|:: ||...:|.:||||:|||:..||.|:.|.:|:||.|:|.||:..::|...:||:
plant   277 PERGYDEDVDLGDDTRFIEFYNLVFMQYNKTEDGLLEPLKQKNIDTGLGLERIAQILQKVPNNYE 341

  Fly   259 TDLFVPLFDAIQAGTGAPPYQGRVGADDV-DGIDMAYRVLADHARTITIALADGGTPDNTGRGYV 322
            |||..|:...|..       ...:..|.. |....:.:|:|||.|.:...::||.:|.|.|||||
plant   342 TDLIYPIIAKISE-------LANISYDSANDKAKTSLKVIADHMRAVVYLISDGVSPSNIGRGYV 399

  Fly   323 LRRILRRAVRYATE-------KLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQ 380
            :||::|||||....       ..|.|..|...:...|::|......:||.....||:.|.:|||.
plant   400 VRRLIRRAVRKGKSLGINGDMNGNLKGAFLPAVAEKVIELSTYIDSDVKLKASRIIEEIRQEELH 464

  Fly   381 FLKTLTRGRNLLNRTI-------EKLGNQTTIPGDVAWRLYDTYGFPVDLTQLMAEEKSLKIDMD 438
            |.|||.||..||::.:       :|..:...:.|..|:.||||:||||::|..:|||:.:.|||:
plant   465 FKKTLERGEKLLDQKLNDALSIADKTKDTPYLDGKDAFLLYDTFGFPVEITAEVAEERGVSIDMN 529

  Fly   439 GYEAAKHNSYVLSQGKGASKIEEINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSAYN--- 500
            |:|....|....||.            .|.:.:|                 .|.|:.|...|
plant   530 GFEVEMENQRRQSQA------------AHNVVKL-----------------TVEDDADMTKNIAD 565

  Fly   501 -----YGVCNSKIV--ALRFENQFVNEITSGQKAGIVLDKTNFYAESGGQIYDQG---------- 548
                 |...:::.|  :|....:.|..::.|.:..::||:|.|||||||||.|.|
plant   566 TEFLGYDSLSARAVVKSLLVNGKPVIRVSEGSEVEVLLDRTPFYAESGGQIADHGFLYVSSDGNQ 630

  Fly   549 --ALVKVNDEANEFLVDRVYNRGGYILHIGVVE-GTLKVGDELELHIDVERRWLTMKNHSATHAL 610
              |:|:|:|......:         .:|.|.|: |.|:||.|:|..:|.:.|.....:|:|||.|
plant   631 EKAVVEVSDVQKSLKI---------FVHKGTVKSGALEVGKEVEAAVDADLRQRAKVHHTATHLL 686

  Fly   611 NHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMTIEQVSKTEQLTKEMVYKNVPIYAKESKLAL 675
            ...|.:|:|::|.|.||||..::||||||...::...::.:.|.|....:.....:..|...||.
plant   687 QSALKKVVGQETSQAGSLVAFDRLRFDFNFNRSLHDNELEEIECLINRWIGDATRLETKVLPLAD 751

  Fly   676 AKKIRGLRSVFDEVYPD-PVRVISFGVPVDELEQNPDSEAGEQTSVEFCGGTHLRRSGHIMDFVI 739
            ||: .|..::|.|.|.: .|||:.  ||              ..|:|.|||||:..:..|..|.|
plant   752 AKR-AGAIAMFGEKYDENEVRVVE--VP--------------GVSMELCGGTHVGNTAEIRAFKI 799

  Fly   740 SSEEAIAKGIRRIVALTGPEALKALKKSEAFEQEIVRLKATIDNDKSGKDSKSHVKEIVELTEQI 804
            .||:.||.|||||.|:.|...::.:...::   ::.||.:|:  ....:|..:.|:.::|
plant   800 ISEQGIASGIRRIEAVAGEAFIEYINSRDS---QMTRLCSTL--KVKAEDVTNRVENLLE----- 854

  Fly   805 SHATIPYVKKDEMRNLLKGLKKTLDDKERALRAAVSVTVVERAKTLCEANPNATVLVEQLEAFNN 869
                           .|:..:|...|. |:..|....:|:.........:....||||.::. .:
plant   855 ---------------ELRAARKEASDL-RSKAAVYKASVISNKAFTVGTSQTIRVLVESMDD-TD 902

  Fly   870 TKALDAALKQVRSQLPDAAAMFLSVDADSKKIFCLSSVPKSAVEKGLKANEWVQHVSATLGGKGG 934
            ..:|.:|.:.:.|.|.|..|:.|....:..|:..:::.....|..|::|.:::..::...||.||
plant   903 ADSLKSAAEHLISTLEDPVAVVLGSSPEKDKVSLVAAFSPGVVSLGVQAGKFIGPIAKLCGGGGG 967

  Fly   935 GKPESAQASGTNYEKVDEIVQLASKFAQSKLS 966
            |||..|||.|...|.:...::.|.:...:.||
plant   968 GKPNFAQAGGRKPENLPSALEKAREDLVATLS 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	324/999 (32%)
		AlaRS_core	6..253	CDD:238360	113/249 (45%)
		tRNA_SAD	529..>626	CDD:298782	39/109 (36%)
		tRNA_SAD	694..752	CDD:285247	22/57 (39%)
		DHHA1	888..957	CDD:280440	18/68 (26%)
EMB1030	NP_001330952.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60684
OrthoDB	1	1.010	-	-		D129373at2759
OrthoFinder	1	1.000	-	-		FOG0001295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100414
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X999
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.690