Protein Alignment AlaRS and aars2

DIOPT Version :10

• Sequence 1: NP_523511.2
• Gene: AlaRS / 34156
• FlyBaseID: FBgn0027094
• Length: 966
• Species: Drosophila melanogaster
• Sequence 2: XP_001332388.5
• Gene: aars2 / 792787
• ZFINID: ZDB-GENE-041008-213
• Length: 1004
• Species: Danio rerio
• Alignment Length: 984
• Identity: 456/984 - (46%)
• Similarity: 612/984 - (62%)
• Gaps: 52/984 - (5%)

  Fly     5 TAKEVRNAYLDFFKE-QKHIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSKWVRV 68
            |:|.||..::|||:| ..|..|.|||..|..||:|||.||||||||||.||.|||.|||..:.||
Zfish    43 TSKRVRRKFIDFFREGYGHRVVPSSSVRPRGDPSLLFVNAGMNQFKPILLGCADPRSEMVSYRRV 107

  Fly    69 ANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLTQRLALPKDRLY 133
            .|:|||:|||||||||.|||||||||||||||||||||||||.|.|:.||..||:...:|..|||
Zfish   108 VNSQKCVRAGGKHNDLQDVGKDVYHHTFFEMLGNWSFGDYFKVEACAMAWRLLTEEYGIPAQRLY 172

  Fly   134 VTYFGGDAASGLEPDLECKQMWLDLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDRIGGRS 198
            |:||.||.|:||..|.|.:.:||.:||:.:|:||..|||||||||||||||||:|:|:|.||.|:
Zfish   173 VSYFSGDPANGLPADEETRDIWLSMGLRADHVLPFGMKDNFWEMGETGPCGPCTEIHYDHIGNRN 237

  Fly   199 VPELVNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYDTDLFV 263
            ...|||.|.|||:|||||||:||||||:|||:.||:..:|.|||.||||:|:|.||||||||||.
Zfish   238 AALLVNADSPDVVEIWNLVFMQYNRESNGSLRALPQCSVDTGMGLERLVTVLQGKRSNYDTDLFT 302

  Fly   264 PLFDAIQAGTGAPPYQGRVGADDVDGIDMAYRVLADHARTITIALADGGTPDNTGRGYVLRRILR 328
            ||..||...:.||.||||.||.||..:||||||:|||.|||.:.:|||..|...|...|||||||
Zfish   303 PLLSAIHQCSKAPAYQGRTGAADVAQLDMAYRVVADHIRTICVCIADGVYPGMAGAELVLRRILR 367

  Fly   329 RAVRYATEKLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGRNLLN 393
            ||||::||.|.|..|..|:||.||..|||||:||:..:...|:|:||:.|..||.:|.:||.:::
Zfish   368 RAVRFSTEVLQAPEGALASLVPTVAHLLGDAYPELNTESDRIMDLINQNEAHFLSSLKQGRRVID 432

  Fly   394 RTIEKLG-NQTTIPGDVAWRLYDTYGFPVDLTQLMAEE-------KSLKIDMDGYEAAKHNSYVL 450
            ||:..:. |.:..|..|||.||...|||:||..||.||       |.:|:..|.||...    :.
Zfish   433 RTLSNMDENSSFFPASVAWSLYRNLGFPLDLIDLMLEEKGKIVDKKEMKVLEDEYEKLG----LQ 493

  Fly   451 SQGKGASKIEEINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSAYNYGVCNSKIVALRFEN 515
            |:.....|:::  ||:|::::||.|.||.|:|:.||.|...|   |..|.:..|.:.::||..:.
Zfish   494 SEEDEGEKLDQ--LDLHSLAELQRQRVPHTDDSPKYCYSVGS---DGQYVFEPCKASVLALYCDG 553

  Fly   516 QFVNEITSGQKAGIVLDKTNFYAESGGQIYDQGALVKVNDEANEFLVDRVYNRGGYILHIGVVEG 580
            ..|:|:..||...::||:|:||||.|||..|||...|...:...|.|..|...|||::|......
Zfish   554 ALVSEVRQGQHCAVILDQTSFYAEQGGQANDQGYFTKDGLQDVLFPVKCVRLAGGYVVHKVTAAE 618

  Fly   581 TLKVGDELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMT 645
            ||:.||::.||:|...|...|.||:|||.||..|.::||....|:||.....:|||||:.|..:|
Zfish   619 TLRTGDQVHLHVDEAWRLGCMINHTATHVLNFALRELLGPIVSQRGSHCSANRLRFDFSVKGTLT 683

  Fly   646 IEQVSKTEQLTKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPDPVRVISFGVPVDELEQNP 710
            :.::.|.|:|...::.:|..::.:|..|:.||:|.|||:| ||:|||||||:|..|||.:|..
Zfish   684 VSELQKVEELVLNIIRQNADVHVEEVPLSSAKQIAGLRTV-DELYPDPVRVVSVAVPVSDLLA-- 745

  Fly   711 DSEAGEQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSEAFEQEIV 775
             ||..||||||.|.||||.|:|.|.|||:.||..:.||:.||||.||.:|:||.:..:|.::|:.
Zfish   746 -SERAEQTSVELCCGTHLLRTGAIRDFVVVSERQMMKGVCRIVAFTGDDAIKAREAGQALQEELE 809

  Fly   776 RLKAT--IDNDKSGKDSKSHVKEIVELTEQISHATIPYVKKDEMRNLLKGLKKT-------LDDK 831
            .|:|.  :.|..|.:::|...||:..|...:....:|..|:.|::..||.:.|:       |:.|
Zfish   810 SLEARMGLSNTLSIQEAKRLSKEVGHLINAVDITPMPQWKRLELQTRLKAMLKSSNNSIRKLEIK 874

  Fly   832 ERALRAAVSVTVVERAKTLCEANPNATVLVEQLEAFNNTKALDAALK---QVRSQLPDAAAMFLS 893
            |.||          :||.|.:.:.|..|:|:.::    |.::...:|   |:....|.:..|..|
Zfish   875 EAAL----------KAKELLDKHSNKPVVVDLIQ----TDSISVLMKTVVQLSKSTPKSLVMLFS 925

  Fly   894 VDADSKKIFCLSSVPKSAVEKGLKANEWVQHVSATLGGKGGGKPESAQASG--TNYEKVDEIVQL 956
            ....|.|:.|...|||.:.  |..|.||...|.:.|||...|..::|:..|  ...|.|.||:..
Zfish   926 HWESSGKLLCACLVPKGST--GGSAIEWALSVCSRLGGNAEGAKDTAKGVGNAVKVEDVAEILHW 988

  Fly   957 ASKFAQSKL 965
            |.:||.:|:
Zfish   989 AEEFAHNKI 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	455/980 (46%)
aars2	XP_001332388.5	PLN02900	41..993	CDD:215487	453/978 (46%)