DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AlaRS and AARS2

DIOPT Version :9

Sequence 1:	NP_523511.2	Gene:	AlaRS / 34156	FlyBaseID:	FBgn0027094	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_065796.2	Gene:	AARS2 / 57505	HGNCID:	21022	Length:	985	Species:	Homo sapiens

Alignment Length:	974	Identity:	422/974 - (43%)
Similarity:	607/974 - (62%)	Gaps:	41/974 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AKEVRNAYLDFFKEQK-HIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSKWVRVA 69
            |..||.|:|:||:::. |..|.|:|..|..||:|||.||||||||||||||.||.|||:.:.|||
Human    39 ASAVRAAFLNFFRDRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVA 103

  Fly    70 NTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSF-GDYFKKEICSWAWEFLTQRLALPKDRLY 133
            |:|||:||||.||||:|||:|:.|||||||||||:| |:|||:|.|:.|||.|||...:|::||:
Human   104 NSQKCVRAGGHHNDLEDVGRDLSHHTFFEMLGNWAFGGEYFKEEACNMAWELLTQVYGIPEERLW 168

  Fly   134 VTYFGGDAASGLEPDLECKQMWLDLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDRIGGRS 198
            ::||.||..:||:||||.:.:||.||:....:|....::||||||:|||||||:|:|:|..||..
Human   169 ISYFDGDPKAGLDPDLETRDIWLSLGVPASRVLSFGPQENFWEMGDTGPCGPCTEIHYDLAGGVG 233

  Fly   199 VPELVNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYDTDLFV 263
            .|:||        |:|||||:|:|||:||||:.||::|:|.|||.||||:|:|.|.|.||||||.
Human   234 APQLV--------ELWNLVFMQHNREADGSLQPLPQRHVDTGMGLERLVAVLQGKHSTYDTDLFS 290

  Fly   264 PLFDAIQAGTGAPPYQGRVGADDVDGIDMAYRVLADHARTITIALADGGTPDNTGRGYVLRRILR 328
            ||.:|||.|..||||.||||..|....|.||||:|||.||:::.::||..|..:|...|||||||
Human   291 PLLNAIQQGCRAPPYLGRVGVADEGRTDTAYRVVADHIRTLSVCISDGIFPGMSGPPLVLRRILR 355

  Fly   329 RAVRYATEKLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGRNLLN 393
            ||||::.|.|.|.|||..:||..||:.||||:||::::...|.::::|:|..||.:|.|||.:::
Human   356 RAVRFSMEILKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIID 420

  Fly   394 RTIEKLGNQTTIPGDVAW--RLYDTYGFPVDLTQLMAEEKSLKIDMDG-----YEAAKHNSYVLS 451
            ||:..||.....|.:|||  .|....|.|:|:.:||.|||.:::|..|     .|.|:|.:   .
Human   421 RTLRTLGPSDMFPAEVAWSLSLCGDLGLPLDMVELMLEEKGVQLDSAGLERLAQEEAQHRA---R 482

  Fly   452 QGKGASKIEEINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSAYNYGVCNSKIVALRFEN- 515
            |.:...| :.:.|||||:.:||.||||||:|:.||.|   |.....:|.:|.|.::::.|..|:
Human   483 QAEPVQK-QGLWLDVHALGELQRQGVPPTDDSPKYNY---SLRPSGSYEFGTCEAQVLQLYTEDG 543

  Fly   516 QFVNEITSGQKAGIVLDKTNFYAESGGQIYDQGALVKVNDEANEFLVDRVYNRGGYILHIGVVEG 580
            ..|..:..||:.|::||:||||||.|||..|:|.||:...|...|.|.|....||:|||..|...
Human   544 TAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVRAGQEDVLFPVARAQVCGGFILHEAVAPE 608

  Fly   581 TLKVGDELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMT 645
            .|::||:::||:|...|...|..|:|||.||..|.|.||..|||:||.:.||:||.|..::..:|
Human   609 CLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLDVTTQTPLT 673

  Fly   646 IEQVSKTEQLTKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPDPVRVISFGVPVDELEQNP 710
            .||:...|...:|.|.::..:|.:|..|||..::.||||: ||||||||||:|.||||.. ..:|
Human   674 PEQLRAVENTVQEAVGQDEAVYMEEVPLALTAQVPGLRSL-DEVYPDPVRVVSVGVPVAH-ALDP 736

  Fly   711 DSEAGEQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSEAFEQEIV 775
            .|:|..|||||.|.||||.|:|.:.|.||..:..::||..|::|:||.:|.:|.:..::..||:
Human   737 ASQAALQTSVELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRLLAVTGEQAQQARELGQSLAQEV- 800

  Fly   776 RLKATIDNDKSGKDSKSHV----KEIVELTEQISHATIPYVKKDEMRNLLKGLKKTLDDKERALR 836
              ||..:....|....:..    |:|..|.|.:..|.:|..::.|:...:|.|::..:...|.|:
Human   801 --KAATERLSLGSRDVAEALRLSKDIGRLIEAVETAVMPQWQRRELLATVKMLQRRANTAIRKLQ 863

  Fly   837 AAVSVTVVERAKTLCEANPNATVLVEQLEAFNNTKALDAALKQVRSQLPDAAAMFLSVDADSKKI 901
            ..   ...::.:.|.|.:....::|:.:.| .:...|...::|:..|.|..:.:.|| .....|:
Human   864 MG---QAAKKTQELLERHSKGPLIVDTVSA-ESLSVLVKVVRQLCEQAPSTSVLLLS-PQPMGKV 923

  Fly   902 FCLSSVPKSAVEKGLKANEWVQHVSATLGGKGGGKPESAQASGTNYEKVDEIVQLASKFAQSKL 965
            .|...|.:.|:.. ..|..|...|.:.:|||..|....||.:|:..: ::..:.:|..:|.|:|
Human   924 LCACQVAQGAMPT-FTAEAWALAVCSHMGGKAWGSRVVAQGTGSTTD-LEAALSIAQTYALSQL 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	420/970 (43%)
		AlaRS_core	6..253	CDD:238360	145/248 (58%)
		tRNA_SAD	529..>626	CDD:298782	46/96 (48%)
		tRNA_SAD	694..752	CDD:285247	28/57 (49%)
		DHHA1	888..957	CDD:280440	16/68 (24%)
AARS2	NP_065796.2	tRNA-synt_2c	46..983	CDD:332954	416/963 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60684
OrthoDB	1	1.010	-	-		D129373at2759
OrthoFinder	1	1.000	-	-		FOG0001295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100414
Panther	1	1.100	-	-	O	PTHR11777
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X999
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.830