DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AlaRS and cdc23

DIOPT Version :9

Sequence 1:	NP_523511.2	Gene:	AlaRS / 34156	FlyBaseID:	FBgn0027094	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_957227.1	Gene:	cdc23 / 393907	ZFINID:	ZDB-GENE-040426-866	Length:	579	Species:	Danio rerio

Alignment Length:	666	Identity:	119/666 - (17%)
Similarity:	215/666 - (32%)	Gaps:	237/666 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 PPYQGRVGADDVDGIDMA--YRVLADHARTITIALA----------------------DGGTPDN 316
            ||......|.|:|.:.:|  |..|.::.|.......                      |..|.|:
Zfish    56 PPELTEEDAQDLDALCLAKSYFDLKEYDRAAYFLRGCRSQKAYFLYMYSRYLSGEKKKDDETVDS 120

  Fly   317 TG---RGYVLRRILRRAVRYATEKLNA--KPGFFATLVNTV---VDLLGDAFPEVKKDPQHIIDI 373
            .|   :|.|....||......::|.:|  ..||...|...|   :|||.:|. |:.....|.:.:
Zfish   121 LGPLEKGQVRNEALRELRVELSKKHSAGELDGFALYLYGVVLRKLDLLKEAV-EIFVAATHALPL 184

  Fly   374 INEEELQFLKTLTRGRNLLNRTIEKLGNQTTIPGDVAWRLYDTYGFPVDLTQLMAEEKSLKIDMD 438
            .....|:....:|        .||.| ...::|.  .| :.|.:     :..:..|.:.:|..:.
Zfish   185 HWGSWLELCNLIT--------NIEML-KSLSLPD--CW-VRDFF-----MAHMYTELQMIKEALQ 232

  Fly   439 GYEA------AKHNSYVLSQ-GKGASKIEEINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERD 496
            .|::      || :||::|| ......|.:|:..::..::|:||      |.|:.      :..|
Zfish   233 KYQSLMEAGFAK-SSYIISQIAVAYHNIRDIDQALYLFNELREQ------DPFRI------ENMD 284

  Fly   497 SAYNYGVCNSKIVALRFENQFVNEITSGQKAGIVLDK---------TNFYA----ESGGQIYDQG 548
            :..|          |.:......|::......:.:||         .|:|:    .....:|.|.
Zfish   285 TFSN----------LLYVRSMKPELSYLAHNLVEIDKYRVETCCVIGNYYSLRSQHEKAALYFQR 339

  Fly   549 ALVKVNDEANEFLVDRVYNRGGYILHIGVVEGTLKVGDELELHIDVERRWLTMKNHSAT-HALNH 612
            || |:|...          .|.:.|          :|.|          ::.|||.||. .|..|
Zfish   340 AL-KLNPRC----------LGAWTL----------MGHE----------YMEMKNTSAAIQAYRH 373

  Fly   613 CLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMTIEQVSKTEQLTKEMVYKNVPIYAKESKLALAK 677
            .:                      :.|.:.......:.:|.::.|      :|.|:    |...:
Zfish   374 AI----------------------EVNKRDYRAWYGLGQTYEILK------MPFYS----LYYYR 406

  Fly   678 KIRGLRSVFDEVYPDPVR-VISFGVPVDELEQNPDSEAGEQTSVEFCGGTHLRRSGHIMDFVISS 741
            |...||       |:..| :::.|...::|.|..:::
Zfish   407 KAHQLR-------PNDSRMLVALGECYEKLSQQLEAK---------------------------- 436

  Fly   742 EEAIAKGIRRIVALTGPEALKALKKSEAFEQEIVRLKATIDNDKSGKDSKSHVKEIVELTEQISH 806
                 |...|..::...|.:..||.::..||       ..::|.:.:....::::|....||:.|
Zfish   437 -----KCYWRAYSVGDVERMALLKLAKLHEQ-------LNESDDAAQCYIIYIQDIFSCGEQLEH 489

  Fly   807 ATIP----YVKKDEMRNLLKGLKKTLDDKERALRAAVSVTVVERAKTLCEANPNATVLVEQLEAF 867
            |.:.    |:.:...:|      |..|:....            |:..|:.|          :|.
Zfish   490 AEVSTALRYLGQYYFKN------KLYDEASLC------------AQRCCDYN----------DAR 526

  Fly   868 NNTKALDAALKQVRSQ 883
            ...|||...:..||.|
Zfish   527 EEGKALLRQISAVREQ 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	119/666 (18%)
		AlaRS_core	6..253	CDD:238360
		tRNA_SAD	529..>626	CDD:298782	21/110 (19%)
		tRNA_SAD	694..752	CDD:285247	5/58 (9%)
		DHHA1	888..957	CDD:280440
cdc23	NP_957227.1	ANAPC8	11..137	CDD:281973	17/80 (21%)
		TPR repeat	314..342	CDD:276809	6/28 (21%)
		TPR repeat	347..377	CDD:276809	11/81 (14%)
		TPR_11	350..413	CDD:290150	19/121 (16%)
		TPR_1	350..381	CDD:278916	11/72 (15%)
		TPR repeat	382..410	CDD:276809	6/37 (16%)
		TPR repeat	416..444	CDD:276809	6/60 (10%)
		TPR repeat	450..473	CDD:276809	5/29 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900