DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AlaRS and AlaRS-m

DIOPT Version :9

Sequence 1:	NP_523511.2	Gene:	AlaRS / 34156	FlyBaseID:	FBgn0027094	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_523932.2	Gene:	AlaRS-m / 38595	FlyBaseID:	FBgn0028962	Length:	1012	Species:	Drosophila melanogaster

Alignment Length:	1057	Identity:	349/1057 - (33%)
Similarity:	520/1057 - (49%)	Gaps:	153/1057 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KLLTAKEVRNAYLDFFK-EQKHIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGT-ADPNSEMSK 64
            ::|||:|:|..:||.|. ...|.:|.||..:|..|||:.|.||||||||.:|||| |.|:.
  Fly    10 RVLTAREIRKTFLDHFTVNHGHKFVRSSPVVPFCDPTVAFVNAGMNQFKSVFLGTAAAPHK---- 70

  Fly    65 WVRVANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLTQRLALPK 129
              ||.|:|||:|.|||||||..||.|.|||||||||||||||||||:|.|:.|.|.|.....:..
  Fly    71 --RVVNSQKCVRVGGKHNDLSVVGTDGYHHTFFEMLGNWSFGDYFKREACAMALELLRGPYNIDP 133

  Fly   130 DRLYVTYFGGDAASGLEPDLECKQMWLDLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDR- 193
            .|||||||.||...|:..||||.::|..||.....|||....|||||||.|||||||:|:|.|.
  Fly   134 GRLYVTYFAGDKVLGIPADLECFEIWRSLGFPASRILPFGCADNFWEMGATGPCGPCTEIHIDHR 198

  Fly   194 --IGGRSVPE---LVNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNK 253
              :|  ||.:   |||....|:.|:||||||||||.:|||:.|||..|:|.|||||||.:|:|||
  Fly   199 PDLG--SVEQRAKLVNAGRSDLTELWNLVFIQYNRHADGSISQLPAHHVDTGMGFERLTAVLQNK 261

  Fly   254 RSNYDTDLFVPLFDAIQAGTGAPPYQGRVGADDVDG-----IDMAYRVLADHARTITIALADGGT 313
            .||||||||.|:||.||.....|.|.|..    .||     :|.:||:||||||.:|..||||..
  Fly   262 SSNYDTDLFTPIFDGIQQAAKTPVYSGSF----PDGGNAAVLDTSYRILADHARMVTACLADGML 322

  Fly   314 PDNTGRGYVLRRILRRAVRYATEKLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDII-NEE 377
            ||...:   |||:||:|:. .:|.:.|.......||..||:.||:|:||:....|.:||:| :|:
  Fly   323 PDQNQK---LRRVLRKALN-ISEHVFAHDKLLTQLVPIVVETLGEAYPEMAAKQQAVIDLICHEQ 383

  Fly   378 EL----------QFLKTLTRGRNL-------------LNRTIE----KLGNQTTIPGDVAWRLYD 415
            |:          .|.:.|....||             ..|.::    |..| .|||||..::|.|
  Fly   384 EVYKNLRESSSKAFAEVLMEFPNLDDIDLMECPGFVPAYRELQMQRCKFSN-NTIPGDFLYKLTD 447

  Fly   416 TYGFPVDLTQLMAEEKSLKIDMDGYEA--------AKHNSYVLSQGKGASKIEEINLDVHAISQL 472
            |||...:....:||.:::..|::.|.|        ||.|....:.|.......|..: ..|.:.|
  Fly   448 TYGLTEESFLKLAELENMNCDLERYRAEVSLAKLKAKGNQRETAGGSLCDLATEQRI-AEAQAML 511

  Fly   473 QEQGVPPTNDTFKYKYEAVSDERDSAYNYGVCNSKIVALRFENQFVNEITSGQK--------AGI 529
            .:: :.||:::.||.|.  .|:...:|......::::.:...:..|:. |.|.:        ..|
  Fly   512 TKR-LTPTDNSHKYTYS--FDKESDSYQIPPLKTRVLGMLLNDAEVSR-TQGSRIQQPFTDLISI 572

  Fly   530 VLDKTNFYAESGGQIYDQGALVKVN----DEANEFLVDRVYNRGGYILHIGVVEG-----TLKVG 585
            |...:|||.|||||..|.|.::..|    |..:...|..|.:....::||..:..     .|.:|
  Fly   573 VTAGSNFYYESGGQQSDGGKILVSNHQQPDHPHSLDVIGVKHLNDCVVHICKLSSPTDAFQLAIG 637

  Fly   586 DELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMTIEQVS 650
            ||:||.:|.::|.|...:|:|||.||..:..:..|.|.|..|.|..::.:.:.    .:..:::.
  Fly   638 DEVELQVDAQQRQLNTCHHTATHLLNAAIRSLFKKVTYQVSSSVSSDQCKLEL----GLLGKRIQ 698

  Fly   651 KTE-QLTKEMVYKNV----PIYAKESKLALAKKIRGLRSVFDEVYPDP-VRVISFGVPVDELEQN 709
            ||: ||.::::.:.:    |:..:....|...:...:..|..||||:. :|::           |
  Fly   699 KTDVQLIEDLINRVICSAAPVEVQLLSAAEVLEQNDITMVPGEVYPEQGLRLV-----------N 752

  Fly   710 PDSEAGEQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSEAFEQEI 774
            .:|...:.:|.|.|.|||...:..:..|.|.:.:...:......|:.|..|...||.:......:
  Fly   753 VESPELQLSSKELCCGTHATNTSELSCFCIVNLKQTNRARFAFTAVAGQAAENVLKTAALLRHRV 817

  Fly   775 VRLKATIDNDKSGKDSKSHVKEIVELTEQISHATI--PYV-KKDEMRNLLKGLKKTLDDKERALR 836
            ..|:.....||....:::   |:..:...:.|..|  ||. |.|.:..:.:.||:..|.....|:
  Fly   818 DLLEKQFQTDKLTNATEA---ELQTIRHNMLHTDIKLPYAFKMDTLERITEMLKRIKDSSRTTLK 879

  Fly   837 AAVSVTVVERAKTLCEANP-----------NATVLVEQLEAFNNTKALDAALKQVRSQLPDAAAM 890
            ..|.|.:    :||.:..|           .::.|||::           .|::.....||...:
  Fly   880 EFVDVEM----RTLLQEKPLDTHPFILHYITSSALVEEI-----------PLQRATKLCPDRPIL 929

  Fly   891 FLSVDADSKKIFCLSSVPKSAVEKGLKANEWVQHVSATLGGK----GGGKPESA------QASGT 945
            .:||.....|..|  .||:..:.:...|:.|:|..:.|..|:    .|..|::.      :.|..
  Fly   930 VISVCDSVVKARC--CVPEKCITEKFNASAWLQSFADTFNGQIAAPKGQNPQAVCNMKGRRVSNL 992

  Fly   946 NYEKVDEIVQLASKFAQ 962
            ..|::::.:..|..:|:
  Fly   993 FEEQLEQAMSKAHAYAK 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	348/1054 (33%)
		AlaRS_core	6..253	CDD:238360	142/254 (56%)
		tRNA_SAD	529..>626	CDD:298782	36/105 (34%)
		tRNA_SAD	694..752	CDD:285247	11/57 (19%)
		DHHA1	888..957	CDD:280440	15/78 (19%)
AlaRS-m	NP_523932.2	PLN02900	13..1010	CDD:215487	348/1054 (33%)
		AlaRS_core	14..261	CDD:238360	142/254 (56%)
		tRNA_SAD	570..>667	CDD:298782	33/96 (34%)
		tRNA_SAD	748..>784	CDD:197931	11/46 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464492
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0013
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S431
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129373at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11777
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.800