DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AlaRS and Cdc23

DIOPT Version :9

Sequence 1:	NP_523511.2	Gene:	AlaRS / 34156	FlyBaseID:	FBgn0027094	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_001260629.1	Gene:	Cdc23 / 35315	FlyBaseID:	FBgn0032863	Length:	678	Species:	Drosophila melanogaster

Alignment Length:	602	Identity:	120/602 - (19%)
Similarity:	204/602 - (33%)	Gaps:	170/602 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   465 DVH----------AISQLQEQGVPPT--NDTFKYK-YEAVSDERDSAYNYGVCNSKIVALRFENQ 516
            |||          ..|:.|.:|:.|.  :|.|..| |..|.:...:|:....|.|.:.  ||.:
  Fly    46 DVHIDNEAPDEDRTFSECQLEGIAPEEYSDYFLAKSYYDVREYDRAAHAVRNCESSVP--RFLH- 107

  Fly   517 FVNEITSGQKAGI--VLDKTNF-------------------YAES---GGQIYDQGALVK---VN 554
            |.:...:.:|..:  ..|:.|.                   |.:|   |..||..|.::|   :|
  Fly   108 FYSSYMAREKRRLDSTTDQANLHEPNQMRDLADLLATLRMEYGKSRLDGYGIYLYGVVLKALNLN 172

  Fly   555 DEANEFLVDRVYNRGGYILHIGVVEGTLKVGDELELHIDVERRWLTMK--NHSATH-ALNHCLLQ 616
            ..|.:.||..          |.:|........||...|..:::.|:::  .|...| .:.|..|:
  Fly   173 QAAEQMLVQA----------IRLVPMLWSAYLELSPLIMEKKKLLSLQLGGHWMRHFFMAHTYLE 227

  Fly   617 VLGKDTEQKGSLVVPEKLRFDFNSKAAMTIEQVSKTEQLTKEMVYKNVPIYAKESKLALAKKIRG 681
            :...|    ..|.:.|.|:....||:...|.|::        :||.|        |..:.|.|..
  Fly   228 LYLND----DGLKIYEDLQASGFSKSIYLIAQMA--------LVYHN--------KRDVDKAIEL 272

  Fly   682 LRSVFDEVYPDPVRV--------ISFGVPVDELEQNPDSEAGEQTSV-----EFC---GGTHLRR 730
            .:::.:.   ||.|:        :.|   |.|::......|.:..|:     |.|   |..:..|
  Fly   273 YQALLES---DPYRLDNVDTYSNLLF---VKEMKTEMAQLAHKAVSINKYRPETCCVIGNYYSIR 331

  Fly   731 SGHIMDFVIS-SEEAIAKGIRRIVA--LTGPEALKALKKSEAFEQEIVRLKATIDNDKSGKDSKS 792
            ..|  ...|| .:.|:....:.:.|  |.|.|.:: ||.:.|..|...:.......|........
  Fly   332 CDH--QVAISYFQRALKLNPKYLAAWTLMGHEFME-LKNTNAAIQSYRKAVEVNKRDYRAWYGLG 393

  Fly   793 HVKEIVELTE------QISHATIP------------YVKKDEMRNLLK----------------- 822
            ...||:::..      :|:|...|            |.|.|:..|.:|
  Fly   394 QAYEIIKMHYYSLYYFKIAHQLRPYDSRMLVALGETYEKLDKCENAVKCYWKAIDVGDIEGIAMY 458

  Fly   823 ---GLKKTLDDKERALRAAVSVTVVERAKT---------LCEANPNATVLVEQLEAFNNTKALDA 875
               .|.:.|.|.|.|:...:.....|||.|         :..||........:..|:...|.||:
  Fly   459 KLANLHEKLGDHETAVHCYIMYCEDERAATDKQSLYQGFITLANYYEKKGEYERAAYYAYKCLDS 523

  Fly   876 ALKQVRSQLPDAAAMFLSVD----ADSKKIFCLSSVPKSAVEKGLKANEW----------VQHVS 926
            ..:::     :|.|:..::|    |:.:|....|:...:|........||          :..::
  Fly   524 EDRKM-----EAKALLKTIDWKRNAEGQKKVKTSTAVANADTSSEDEMEWELQDVRVRVPITSIA 583

  Fly   927 ATLGGKGGGKPESAQAS 943
            .|.........|||.:|
  Fly   584 TTTTSTTTVAAESASSS 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	120/602 (20%)
		AlaRS_core	6..253	CDD:238360
		tRNA_SAD	529..>626	CDD:298782	24/126 (19%)
		tRNA_SAD	694..752	CDD:285247	14/74 (19%)
		DHHA1	888..957	CDD:280440	13/70 (19%)
Cdc23	NP_001260629.1	ANAPC8	11..119	CDD:281973	19/75 (25%)
		TPR	235..507	CDD:223533	59/296 (20%)
		TPR repeat	255..278	CDD:276809	7/38 (18%)
		TPR repeat	318..346	CDD:276809	8/29 (28%)
		TPR repeat	351..381	CDD:276809	8/30 (27%)
		TPR repeat	386..414	CDD:276809	3/27 (11%)
		TPR repeat	420..448	CDD:276809	5/27 (19%)
		TPR repeat	454..477	CDD:276809	5/22 (23%)
		TPR repeat	494..522	CDD:276809	4/27 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0013
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900