DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AlaRS and Aars2

DIOPT Version :9

Sequence 1:	NP_523511.2	Gene:	AlaRS / 34156	FlyBaseID:	FBgn0027094	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	XP_006244575.1	Gene:	Aars2 / 301254	RGDID:	1310617	Length:	1057	Species:	Rattus norvegicus

Alignment Length:	1044	Identity:	433/1044 - (41%)
Similarity:	610/1044 - (58%)	Gaps:	110/1044 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VRNAYLDFFKEQK-HIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSKWVRVANTQ 72
            ||:|:|.||:::. |..|.|:|..|..||:|||.||||||||||||||.||.|||:.:.||||:|
  Rat    37 VRDAFLSFFRDRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVANSQ 101

  Fly    73 KCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSF-GDYFKKEICSWAWEFLTQRLALPKDRLYVTY 136
            ||:||||:||||:|||:|:.|||||||||||:| |:|||||.||.|||.|||...:|:|||:|:|
  Rat   102 KCVRAGGRHNDLEDVGRDLSHHTFFEMLGNWAFGGEYFKKEACSMAWELLTQVYGIPEDRLWVSY 166

  Fly   137 FGGDAASGLEPDLECKQMWLDLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDRIGGRSVPE 201
            |.||:.:||:||||.:.:||.||:....:|...:::||||||:|||||||:|:|:|..||...|:
  Rat   167 FSGDSKTGLDPDLETRDIWLSLGVPASRVLSFGLQENFWEMGDTGPCGPCTEIHYDLAGGMGPPQ 231

  Fly   202 LVNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYDTDLFVPLF 266
            ||        |:|||||:|:.||:||||..||::|:|.|||.||||:|:|.|.|.||||||.||.
  Rat   232 LV--------ELWNLVFMQHYREADGSLHLLPQQHVDTGMGLERLVAVLQGKHSTYDTDLFSPLL 288

  Fly   267 DAIQAGTGAPPYQGRVGADDVDGIDMAYRVLADHARTITIALADGGTPDNTGRGYVLRRILRRAV 331
            |||......|||.|||||.|...||.||||:|||.||:::.:|||.:|..:|...||||||||||
  Rat   289 DAIHQSCRVPPYSGRVGAADEGRIDTAYRVVADHIRTLSVCIADGVSPGMSGAPLVLRRILRRAV 353

  Fly   332 RYATEKLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGRNLLNRTI 396
            ||:||.|.|.|||...||..||..||.|:||::|:...|.::::|:|..||.:|.|||.:::||:
  Rat   354 RYSTEVLQAPPGFLGNLVPVVVATLGAAYPELQKNSVKIANLVSEDEAAFLASLQRGRRIIDRTV 418

  Fly   397 EKLGNQTTIPGDVAW--RLYDTYGFPVDLTQLMAEEKSLKIDMDGYE--AAKHNSYVLSQGKGAS 457
            ::||.....|.:|||  .|....|.|:||.|||.|||.:|:|..|.|  |.|...:...|.:.|.
  Rat   419 KRLGPSDLFPAEVAWSLSLSGNLGIPLDLVQLMLEEKGVKLDTAGLEQLAQKEAQHRAQQAEAAQ 483

  Fly   458 KIEEINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSAYNYGVCNSKIVALRFE-NQFVNEI 521
            : |.:.|||||:.:|..||:|.|:|:.||.|   |...:..|.:|:|.::::.|..| ...|..:
  Rat   484 E-EGLCLDVHALEELHRQGIPTTDDSPKYNY---SLRPNGDYEFGLCEAQVLQLYSETGTAVASV 544

  Fly   522 TSGQKAGIVLDKTNFYAESGGQIYDQGALVKVNDEANEFLVDRVYNRGGYILHIGVVEGTLKVGD 586
            ..||:.|::||:||||||.|||..|:|.|::...:...|.|.|....||:|||..:....|:|||
  Rat   545 GEGQRCGLLLDRTNFYAEQGGQASDRGYLIRTGQQDVLFPVARAQVCGGFILHEAMAPECLQVGD 609

  Fly   587 ELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMTIEQVSK 651
            .::|::|...|...|..|:|||.||..|.|.||..|||:||.:.||:||||..::..:|.||:..
  Rat   610 RVQLYVDKAWRMGCMVKHTATHLLNWALRQTLGPTTEQRGSHLNPERLRFDVATQTPLTTEQLRT 674

  Fly   652 TEQLTKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPDPVRVISFGVPVDELEQNPDSEAGE 716
            .|...:|.|.::.|:|.:|..||...:|.||||: ||||||||||:|.||||.: ...|.|:|..
  Rat   675 VESYVQEAVGQDKPVYMEEVPLAHTARIPGLRSL-DEVYPDPVRVVSVGVPVAQ-ALAPASQAAL 737

  Fly   717 QTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSEAFEQEIVRLKATI 781
            |||||.|.||||..:|.:.|.||..:..:.|||.|::|:||.:|.:|.:..::..||:     .:
  Rat   738 QTSVELCCGTHLLSTGAVGDLVIIGDRQLVKGITRLLAITGEQAQQAREVGQSLSQEV-----EV 797

  Fly   782 DNDKSGKDSKSHV------KEIVELTEQISHATIPYVKKDEMRNLLKGL---------------- 824
            .:::..:.|:..:      |:|..|.|....|.||..::.|.:..||.|
  Rat   798 ASERLSRGSRDLLEAHRLSKDIGRLIEFTESAVIPQWQRQEQQTTLKMLQRRANTAIRKLEKSQQ 862

  Fly   825 --------------KKTLDDKERALRAAVS---------VTVVERAK------------------ 848
                          :|..|..:.:.|...|         :..:|||.
  Rat   863 PRGPCDRIEEPRQSQKATDATQESSRTRQSPAHHLSSELMAFMERASMGGRGLSGWVSVQKWNIQ 927

  Fly   849 ---TLCEANPNAT--------------VLVEQLEAFNNTKALDAALKQVRSQLPDAAAMFLSVDA 896
               ..|.:.|.||              ::|:.:.| .:...|...::|:..|.|..:.:.|| ..
  Rat   928 LRPLCCSSAPQATEKSQELLKRHSEGPLIVDTVSA-QSLSVLVKVVRQLCKQAPSMSVLLLS-PQ 990

  Fly   897 DSKKIFCLSSVPKSAVEKGLKANEWVQHVSATLGGKGGGKPESAQASGTNYEKVDEIVQLASKFA 961
            .:..:.|...|.:.|... ..|..|...|.:.:|||..|.|..||.:|...: ::..::.|..:|
  Rat   991 PTGSVLCACQVAQGATPT-FTAEAWALAVCSHMGGKAWGSPVIAQGTGHTAD-LEAALRTARAYA 1053

  Fly   962 QSKL 965
            .::|
  Rat  1054 LNQL 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	432/1040 (42%)
		AlaRS_core	6..253	CDD:238360	147/245 (60%)
		tRNA_SAD	529..>626	CDD:298782	43/96 (45%)
		tRNA_SAD	694..752	CDD:285247	28/57 (49%)
		DHHA1	888..957	CDD:280440	16/68 (24%)
Aars2	XP_006244575.1	PLN02900	34..1055	CDD:215487	432/1040 (42%)
		AlaRS_core	37..275	CDD:238360	147/245 (60%)
		tRNA_SAD	549..>651	CDD:298782	45/101 (45%)
		tRNA_SAD	<740..773	CDD:197931	15/32 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60684
OrthoDB	1	1.010	-	-		D129373at2759
OrthoFinder	1	1.000	-	-		FOG0001295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100414
Panther	1	1.100	-	-	O	PTHR11777
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X999
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.830