Protein Alignment AlaRS and Aars1

DIOPT Version :10

• Sequence 1: NP_523511.2
• Gene: AlaRS / 34156
• FlyBaseID: FBgn0027094
• Length: 966
• Species: Drosophila melanogaster
• Sequence 2: NP_001093987.1
• Gene: Aars1 / 292023
• RGDID: 1304832
• Length: 968
• Species: Rattus norvegicus
• Alignment Length: 969
• Identity: 591/969 - (60%)
• Similarity: 725/969 - (74%)
• Gaps: 17/969 - (1%)

  Fly     4 LTAKEVRNAYLDFFKEQKHIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSKWVRV 68
            |||:|:|..::::||..:|.|||||:||||||||||||||||||||||||.|.||:..|:|..|.
  Rat     5 LTAREIRERFINYFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTVDPSHPMAKLSRA 69

  Fly    69 ANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLTQRLALPKDRLY 133
            |||||||||||||||||||||||||||||||||:||||||||:..|..|.|.|||...:|.:|||
  Rat    70 ANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIPVERLY 134

  Fly   134 VTYFGGDAASGLEPDLECKQMWLDLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDRIGGRS 198
            |||||||.|:||||||||:|:|.:|||....||||:|||||||||:|||||||||:|:||||||.
  Rat   135 VTYFGGDEAAGLEPDLECRQIWQNLGLDEAKILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRD 199

  Fly   199 VPELVNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYDTDLFV 263
            ...|||.|||:||||||||||||||||||.||.||||.||.|||.||||||:|||.|||||||||
  Rat   200 AAHLVNQDDPNVLEIWNLVFIQYNRESDGVLKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFV 264

  Fly   264 PLFDAIQAGTGAPPYQGRVGADDVDGIDMAYRVLADHARTITIALADGGTPDNTGRGYVLRRILR 328
            |.|:|||.||||.||.|:|||:|.||||||||||||||||||:||||||.|||||||||||||||
  Rat   265 PYFEAIQKGTGARPYTGKVGAEDTDGIDMAYRVLADHARTITVALADGGRPDNTGRGYVLRRILR 329

  Fly   329 RAVRYATEKLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGRNLLN 393
            |||||:.|||||..|||||||:.||..|||||||:||||..:.|||||||:||||||:|||.:|:
  Rat   330 RAVRYSHEKLNASRGFFATLVDVVVQSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSRGRRILD 394

  Fly   394 RTIEKLGNQTTIPGDVAWRLYDTYGFPVDLTQLMAEEKSLKIDMDGYEAAKHNSYVLSQGKGASK 458
            |.|:.||:..|||||.||.||||||||||||.|:||||.|.:||||:|..:..:.:.||||||..
  Rat   395 RKIQSLGDCQTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMDGFEEERKLAQLKSQGKGAGG 459

  Fly   459 IEEINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSAYNYGVCNSKIVALRFENQFVNEITS 523
            .:.|.||::||.:|:.:|:..|:|:.||.|.:   :...:|.:....:.::|||.|..||:|:.:
  Rat   460 EDLIMLDIYAIEELRAKGLEATDDSPKYNYHS---DSSGSYVFECTVATVLALRREKMFVDEVVT 521

  Fly   524 GQKAGIVLDKTNFYAESGGQIYDQGALVKVND---EANEFLVDRVYNRGGYILHIGVVEGTLKVG 585
            ||:.|:|||||.||||.||||:|:|.||||:|   :..||.|.....||||:||||.:.|.|:||
  Rat   522 GQECGVVLDKTCFYAEQGGQIFDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYGNLRVG 586

  Fly   586 DELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMTIEQVS 650
            |::.|.||..||...|.||:|||.||..|..||| |.:||||||.|::|||||.:|.||:.||:.
  Rat   587 DQVRLFIDEPRRRPVMSNHTATHILNFALRSVLG-DADQKGSLVAPDRLRFDFTAKGAMSTEQIK 650

  Fly   651 KTEQLTKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPDPVRVISFGVPVDELEQNPDSEAG 715
            |||::...|:....|:|..:..||.||.|:|||:||||.|||||||:|.||||.||..:|...||
  Rat   651 KTEEIVNGMIEAAKPVYTLDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVSELLDDPSGPAG 715

  Fly   716 EQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSEAFEQEI----VR 776
            ..||||||||||||.|.|...|||.:|||||||||||||:||.||.|||:|||..::.:    |:
  Rat   716 SLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKSETLKKSLSAMEVK 780

  Fly   777 LKATIDNDKSGKDSKSHVKEIVELTEQISHATIPYVKKDEMRNLLKGLKKTLDDKERALRAAVSV 841
            :||      ....:|...|||.:|.|.::.|.||..:|||.|..||.|||.:||.:||.:|.|..
  Rat   781 VKA------QSAPNKDVQKEIADLGEVLATAVIPQWQKDEQRETLKSLKKVMDDLDRASKADVQK 839

  Fly   842 TVVERAKTLCEANPNATVLVEQLEAFNNTKALDAALKQVRSQLPDAAAMFLSVDADSKKIFCLSS 906
            .|:|:.|.|.::|||..:::.::|:..:.|||:.|||..::..|..:||..:||.::.||.||..
  Rat   840 RVLEKTKQLIDSNPNQPLVILEMESGASAKALNEALKLFKTHSPQTSAMLFTVDNEAGKITCLCQ 904

  Fly   907 VPKSAVEKGLKANEWVQHVSATLGGKGGGKPESAQASGTNYEKVDEIVQLASKFAQSKL 965
            ||::|..:||||:||||.||..:.||||||..||||:|.|...:.|.:|||:.|||.:|
  Rat   905 VPQNAANRGLKASEWVQQVSGLMDGKGGGKDMSAQATGKNVGCLQEALQLATSFAQLRL 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	588/964 (61%)
Aars1	NP_001093987.1	PLN02900	6..961	CDD:215487	588/964 (61%)
		Nuclear localization signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03133	750..763		9/12 (75%)