DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AlaRS and Aars1

DIOPT Version :9

Sequence 1:	NP_523511.2	Gene:	AlaRS / 34156	FlyBaseID:	FBgn0027094	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_001093987.1	Gene:	Aars1 / 292023	RGDID:	1304832	Length:	968	Species:	Rattus norvegicus

Alignment Length:	969	Identity:	591/969 - (60%)
Similarity:	725/969 - (74%)	Gaps:	17/969 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LTAKEVRNAYLDFFKEQKHIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSKWVRV 68
            |||:|:|..::::||..:|.|||||:||||||||||||||||||||||||.|.||:..|:|..|.
  Rat     5 LTAREIRERFINYFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTVDPSHPMAKLSRA 69

  Fly    69 ANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLTQRLALPKDRLY 133
            |||||||||||||||||||||||||||||||||:||||||||:..|..|.|.|||...:|.:|||
  Rat    70 ANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIPVERLY 134

  Fly   134 VTYFGGDAASGLEPDLECKQMWLDLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDRIGGRS 198
            |||||||.|:||||||||:|:|.:|||....||||:|||||||||:|||||||||:|:||||||.
  Rat   135 VTYFGGDEAAGLEPDLECRQIWQNLGLDEAKILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRD 199

  Fly   199 VPELVNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYDTDLFV 263
            ...|||.|||:||||||||||||||||||.||.||||.||.|||.||||||:|||.|||||||||
  Rat   200 AAHLVNQDDPNVLEIWNLVFIQYNRESDGVLKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFV 264

  Fly   264 PLFDAIQAGTGAPPYQGRVGADDVDGIDMAYRVLADHARTITIALADGGTPDNTGRGYVLRRILR 328
            |.|:|||.||||.||.|:|||:|.||||||||||||||||||:||||||.|||||||||||||||
  Rat   265 PYFEAIQKGTGARPYTGKVGAEDTDGIDMAYRVLADHARTITVALADGGRPDNTGRGYVLRRILR 329

  Fly   329 RAVRYATEKLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGRNLLN 393
            |||||:.|||||..|||||||:.||..|||||||:||||..:.|||||||:||||||:|||.:|:
  Rat   330 RAVRYSHEKLNASRGFFATLVDVVVQSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSRGRRILD 394

  Fly   394 RTIEKLGNQTTIPGDVAWRLYDTYGFPVDLTQLMAEEKSLKIDMDGYEAAKHNSYVLSQGKGASK 458
            |.|:.||:..|||||.||.||||||||||||.|:||||.|.:||||:|..:..:.:.||||||..
  Rat   395 RKIQSLGDCQTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMDGFEEERKLAQLKSQGKGAGG 459

  Fly   459 IEEINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSAYNYGVCNSKIVALRFENQFVNEITS 523
            .:.|.||::||.:|:.:|:..|:|:.||.|.:   :...:|.:....:.::|||.|..||:|:.:
  Rat   460 EDLIMLDIYAIEELRAKGLEATDDSPKYNYHS---DSSGSYVFECTVATVLALRREKMFVDEVVT 521

  Fly   524 GQKAGIVLDKTNFYAESGGQIYDQGALVKVND---EANEFLVDRVYNRGGYILHIGVVEGTLKVG 585
            ||:.|:|||||.||||.||||:|:|.||||:|   :..||.|.....||||:||||.:.|.|:||
  Rat   522 GQECGVVLDKTCFYAEQGGQIFDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYGNLRVG 586

  Fly   586 DELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMTIEQVS 650
            |::.|.||..||...|.||:|||.||..|..||| |.:||||||.|::|||||.:|.||:.||:.
  Rat   587 DQVRLFIDEPRRRPVMSNHTATHILNFALRSVLG-DADQKGSLVAPDRLRFDFTAKGAMSTEQIK 650

  Fly   651 KTEQLTKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPDPVRVISFGVPVDELEQNPDSEAG 715
            |||::...|:....|:|..:..||.||.|:|||:||||.|||||||:|.||||.||..:|...||
  Rat   651 KTEEIVNGMIEAAKPVYTLDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVSELLDDPSGPAG 715

  Fly   716 EQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSEAFEQEI----VR 776
            ..||||||||||||.|.|...|||.:|||||||||||||:||.||.|||:|||..::.:    |:
  Rat   716 SLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKSETLKKSLSAMEVK 780

  Fly   777 LKATIDNDKSGKDSKSHVKEIVELTEQISHATIPYVKKDEMRNLLKGLKKTLDDKERALRAAVSV 841
            :||      ....:|...|||.:|.|.::.|.||..:|||.|..||.|||.:||.:||.:|.|..
  Rat   781 VKA------QSAPNKDVQKEIADLGEVLATAVIPQWQKDEQRETLKSLKKVMDDLDRASKADVQK 839

  Fly   842 TVVERAKTLCEANPNATVLVEQLEAFNNTKALDAALKQVRSQLPDAAAMFLSVDADSKKIFCLSS 906
            .|:|:.|.|.::|||..:::.::|:..:.|||:.|||..::..|..:||..:||.::.||.||..
  Rat   840 RVLEKTKQLIDSNPNQPLVILEMESGASAKALNEALKLFKTHSPQTSAMLFTVDNEAGKITCLCQ 904

  Fly   907 VPKSAVEKGLKANEWVQHVSATLGGKGGGKPESAQASGTNYEKVDEIVQLASKFAQSKL 965
            ||::|..:||||:||||.||..:.||||||..||||:|.|...:.|.:|||:.|||.:|
  Rat   905 VPQNAANRGLKASEWVQQVSGLMDGKGGGKDMSAQATGKNVGCLQEALQLATSFAQLRL 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	588/964 (61%)
		AlaRS_core	6..253	CDD:238360	184/246 (75%)
		tRNA_SAD	529..>626	CDD:298782	55/99 (56%)
		tRNA_SAD	694..752	CDD:285247	39/57 (68%)
		DHHA1	888..957	CDD:280440	35/68 (51%)
Aars1	NP_001093987.1	PLN02900	6..961	CDD:215487	588/964 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342689
Domainoid	1	1.000	819	1.000	Domainoid score	I63
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1213
Inparanoid	1	1.050	1170	1.000	Inparanoid score	I190
OMA	1	1.010	-	-		QHG60684
OrthoDB	1	1.010	-	-		D129373at2759
OrthoFinder	1	1.000	-	-		FOG0001295
OrthoInspector	1	1.000	-	-		oto98287
orthoMCL	1	0.900	-	-		OOG6_100414
Panther	1	1.100	-	-	LDO	PTHR11777
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X999
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770