DRSC/TRiP Functional Genomics Resources

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Protein Alignment AlaRS and Cdc23

DIOPT Version :9

Sequence 1:NP_523511.2 Gene:AlaRS / 34156 FlyBaseID:FBgn0027094 Length:966 Species:Drosophila melanogaster
Sequence 2:NP_001094129.1 Gene:Cdc23 / 291689 RGDID:1304819 Length:597 Species:Rattus norvegicus


Alignment Length:651 Identity:120/651 - (18%)
Similarity:225/651 - (34%) Gaps:218/651 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   342 PGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGRNLLNRTIEKLGNQTTIP 406
            ||     |:||.|.  ....|:||            :|..:..|||.|.||:.:           
  Rat    18 PG-----VSTVADF--SDLREIKK------------QLLLIAGLTRERGLLHSS----------- 52

  Fly   407 GDVAWRLYDTYGFP-VDLTQL-----MAEEKSLKI----------DMDGYEAAKH-----NS--- 447
               .|.....:..| :.|::|     :.||.:..:          |:..|:.|.|     ||   
  Rat    53 ---KWSAELAFSLPALPLSELQPPPPLTEEDAQDVDAYTLAKAYFDVKEYDRAAHFLHGCNSKKA 114

  Fly   448 ---YVLSQG-KGASKIEEINLDVHAISQLQEQGVPPTNDTFK-------YKYEAVSDERDSAYNY 501
               |:.|:. .|..|.::..:|  ::..|::..|  .|:..:       .|::|...:....|.|
  Rat   115 YFLYMYSRYLSGEKKKDDETVD--SLGPLEKGQV--KNEALRELRVELSRKHQARGLDGFGLYLY 175

  Fly   502 GVCNSKI------VALRFENQFVNEITSG---QKAGIVLDK-------------TNFYAESGGQI 544
            ||...|:      :.:..|...|..:..|   :...::.||             ..|:.   ..|
  Rat   176 GVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFL---AHI 237

  Fly   545 YDQGALVKVNDEANEFLVDRVYNRGGYIL--------HIGVVEGTLKVGDELEL-------HIDV 594
            |.:..|::...:..:.|:|..:::..||:        :|..::..|.:.:||..       ::|.
  Rat   238 YTELQLIEEALQKYQHLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDT 302

  Fly   595 ERRWL---TMKNHSATHALNHCLLQ--------VLG-----KDTEQKGSLVVPEKLRFDFNSKAA 643
            ....|   :||:..:..|.|.|.:.        |:|     :...:|.:|.....|:.:.....|
  Rat   303 FSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGA 367

  Fly   644 MTIEQVSKTEQLTKE-MVYKNVPIYAKESKLALAKKIRGLRSVFD-----EVYPDPVRVISFGVP 702
            .|:        :..| |..||.....:..:.|:....|..|:.:.     |:...|...:.:...
  Rat   368 WTL--------MGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRR 424

  Fly   703 VDELEQNPDSEAGEQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKS 767
            ..:|..| ||                                     |.:|||           .
  Rat   425 AHQLRPN-DS-------------------------------------RMLVAL-----------G 440

  Fly   768 EAFEQ--EIVRLK-------ATIDNDKSG--KDSKSHVKEIVELTEQISHATIPYVKKDEMRNLL 821
            |.:|:  ::|..|       |..|.:|..  |.:|.| :::.| :||.:...|.|::.      :
  Rat   441 ECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLH-EQLTE-SEQAAQCYIKYIQD------I 497

  Fly   822 KGLKKTLDDKERALRAAVSVTVVERAKTLCEANPNATVLVEQLEAFNNT----KALDAALKQVRS 882
            ....:|::.    |..:.:...:.:....|:....|:...::..|||:|    |||...:.|:|:
  Rat   498 YSCGETVEH----LEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRN 558

  Fly   883 Q 883
            |
  Rat   559 Q 559

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AlaRSNP_523511.2 PLN02900 5..963 CDD:215487 120/651 (18%)
AlaRS_core 6..253 CDD:238360
tRNA_SAD 529..>626 CDD:298782 23/140 (16%)
tRNA_SAD 694..752 CDD:285247 5/57 (9%)
DHHA1 888..957 CDD:280440
Cdc23NP_001094129.1 ANAPC8 45..148 CDD:397937 22/120 (18%)
TPR repeat 172..197 CDD:276809 6/24 (25%)
TPR repeat 202..257 CDD:276809 8/57 (14%)
TPR 216..451 CDD:223533 46/294 (16%)
TPR repeat 263..291 CDD:276809 6/27 (22%)
TPR repeat 331..359 CDD:276809 4/27 (15%)
TPR repeat 367..393 CDD:276809 7/33 (21%)
TPR repeat 398..428 CDD:276809 3/29 (10%)
TPR repeat 433..461 CDD:276809 9/75 (12%)
TPR repeat 467..495 CDD:276809 9/29 (31%)
TPR repeat 501..536 CDD:276809 4/38 (11%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0013
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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