DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AlaRS and ala1

DIOPT Version :9

Sequence 1:	NP_523511.2	Gene:	AlaRS / 34156	FlyBaseID:	FBgn0027094	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_593640.1	Gene:	ala1 / 2542031	PomBaseID:	SPAC23C11.09	Length:	959	Species:	Schizosaccharomyces pombe

Alignment Length:	969	Identity:	467/969 - (48%)
Similarity:	617/969 - (63%)	Gaps:	30/969 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AKEVRNAYLDFFKEQKHIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSKWVRVAN 70
            |.|:|..:|.:|::..|..|.|||.||.||||||||||||||||||||||.||:|:.:|..|..:
pombe    12 ANEIRRTFLKYFEDHGHTIVPSSSVIPYDDPTLLFANAGMNQFKPIFLGTVDPSSDFAKLKRACD 76

  Fly    71 TQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLTQRLALPKDRLYVT 135
            :|||||||||||||:|||||.||||.||||||||||||||||..:.||:.||....|.||:||||
pombe    77 SQKCIRAGGKHNDLEDVGKDNYHHTMFEMLGNWSFGDYFKKEAIAMAWDLLTNVYGLKKDQLYVT 141

  Fly   136 YFGGDAASGLEPDLECKQMWLDLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDRIGGRSVP 200
            ||||...||||||||.:|:|||:|:....::|||:||||||||:.||||||||:|:||||.|:||
pombe   142 YFGGHEESGLEPDLEARQLWLDIGIDESRVIPGSLKDNFWEMGDQGPCGPCSEIHYDRIGNRTVP 206

  Fly   201 ELVNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYDTDLFVPL 265
            ||||||||:||||||:||||:|||.||||:.||.:|:|.||||||||||||||.||||||:|.|:
pombe   207 ELVNMDDPNVLEIWNIVFIQFNREKDGSLRPLPNRHVDTGMGFERLVSVIQNKTSNYDTDVFSPI 271

  Fly   266 FDAIQAGTGAPPYQGRVGADDVDGIDMAYRVLADHARTITIALADGGTPDNTGRGYVLRRILRRA 330
            |..||..|.|.||.|::|.:||||||.||||:|||.||:|.|::|||.|:|.||||||||||||.
pombe   272 FAKIQELTNARPYTGKMGDEDVDGIDTAYRVVADHVRTLTFAISDGGVPNNEGRGYVLRRILRRG 336

  Fly   331 VRYATEKLNAKPG-FFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGRNLLNR 394
            .||..:|.....| ||:.|..|||:.:||.|||:|:....:.::::|||..|.:||.||..:..:
pombe   337 ARYVRKKFGVPIGNFFSRLSLTVVEQMGDFFPELKRKVDDVRELLDEEEESFSRTLDRGEKMFEQ 401

  Fly   395 --TIEKLGNQTTIPGDVAWRLYDTYGFPVDLTQLMAEEKSLKIDMDGYEAAKHNSYVLSQ--GKG 455
              ...|.....|:.|:..||||:|||||||||.|||||..:|||..|:|||:..|..:|:  .||
pombe   402 YAAAAKKTPSKTLQGNDVWRLYETYGFPVDLTHLMAEEAGIKIDEPGFEAAQARSKEISKQASKG 466

  Fly   456 ASKIEE-INLDVHAISQLQE-QGVPPTNDTFKYKYEAVSDERDSAYNYGVCNSKIVALRFENQFV 518
            .|..:: :.|||||:..|.: ..:|.|:|.||:...::.......|:.|         .|:.. .
pombe   467 GSSGDDLLVLDVHALGALSKMDDIPETDDVFKHNSVSLKSVIKGIYHKG---------GFQKS-T 521

  Fly   519 NEITSGQKAGIVLDKTNFYAESGGQIYDQGALVKVNDEANEFLVDRVYNRGGYILHIGVVE-GTL 582
            ....||::.|::||:||||||.|||.||.|.:  |.|...:|.|..|....||:||.|.:| |.|
pombe   522 EGFNSGEQLGLLLDRTNFYAEQGGQEYDTGHI--VIDGVADFRVTNVQVYAGYVLHTGFLEYGNL 584

  Fly   583 KVGDELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMTIE 647
            .|.|.:....|..|||..|.||:.||.||..|...||...:|:||||..|||||||:.|:::.|:
pombe   585 TVNDSVVCEYDEIRRWHLMNNHTVTHILNLALRNTLGDGIDQRGSLVSQEKLRFDFSYKSSIPID 649

  Fly   648 QVSKTEQLTKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPDPVRVISFGVPVDELEQNPDS 712
            ::...|.....::..|:.:|:||..|:.||:|.|||:||.|||||||||:..||.:|.|.|.|..
pombe   650 KLLLVENYCNNVIQDNLSVYSKEVALSKAKEINGLRAVFGEVYPDPVRVVCIGVDIDTLLQEPKK 714

  Fly   713 EAGEQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSEAFEQEIVRL 777
            ....:.|:|||||||..:||.|.||||..|..||||||||||:|..||.:..:.:..|:..|.:|
pombe   715 PDWTKYSIEFCGGTHCDKSGEIKDFVILEENGIAKGIRRIVAVTSTEANRVSRLANEFDARIAKL 779

  Fly   778 KATIDNDKSGKDSKSHVKEIVELTEQISHATIPYVKKDEMRNLLKGLKKTLDDKERALRAAVSVT 842
            :..       ..|.:...|:.:::..:|...:..|:|..|:..:..:.|.:.:..:|:.||....
pombe   780 EKM-------PFSPAKEAELKKISVDLSKLVVAAVRKHAMKERIAKITKQVQEHVKAINAAEQKE 837

  Fly   843 VVERAKTLCEANPNATVLVEQLEAFNNTKALDAALKQVRSQLPDAAAMFLSVDADSKKIFCLSSV 907
            ||.......:.||:.:.:|.::....|.|||..||...:..|.|.:...|:.|.......||.|
pombe   838 VVNVVTEYFKENPDMSFVVAKVPISANPKALSFALTYAKKNLKDKSIYLLASDDTKVAHACLVS- 901

  Fly   908 PKSAVEKGLKANEWVQHVSATLGGKGGGKPESAQASGTNYEKVDEIVQLASKFAQSKLS 966
            |::.  |.|...||.|.|..::||:.|||.::.|..|.....:|..|:.|.:|.|.||:
pombe   902 PEAM--KKLTPQEWSQKVCHSIGGRSGGKGDTCQGVGDKPLSIDVAVEEAIEFFQGKLT 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	464/964 (48%)
		AlaRS_core	6..253	CDD:238360	173/246 (70%)
		tRNA_SAD	529..>626	CDD:298782	44/97 (45%)
		tRNA_SAD	694..752	CDD:285247	31/57 (54%)
		DHHA1	888..957	CDD:280440	21/68 (31%)
ala1	NP_593640.1	PLN02900	3..952	CDD:215487	463/961 (48%)
		AlaRS_core	12..259	CDD:238360	173/246 (70%)
		tRNA_SAD	532..739	CDD:298782	97/208 (47%)
		DHHA1	881..951	CDD:280440	23/72 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	636	1.000	Domainoid score	I21
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1213
Inparanoid	1	1.050	865	1.000	Inparanoid score	I53
OMA	1	1.010	-	-		QHG60684
OrthoFinder	1	1.000	-	-		FOG0001295
OrthoInspector	1	1.000	-	-		oto101867
orthoMCL	1	0.900	-	-		OOG6_100414
Panther	1	1.100	-	-	LDO	PTHR11777
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1429
SonicParanoid	1	1.000	-	-		X999
TreeFam	1	0.960	-	-
	14	13.860