Protein Alignment AlaRS and Aars1

DIOPT Version :10

• Sequence 1: NP_523511.2
• Gene: AlaRS / 34156
• FlyBaseID: FBgn0027094
• Length: 966
• Species: Drosophila melanogaster
• Sequence 2: NP_666329.2
• Gene: Aars1 / 234734
• MGIID: 2384560
• Length: 968
• Species: Mus musculus
• Alignment Length: 965
• Identity: 585/965 - (60%)
• Similarity: 727/965 - (75%)
• Gaps: 9/965 - (0%)

  Fly     4 LTAKEVRNAYLDFFKEQKHIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSKWVRV 68
            |||:|:|..:::||:..:|.|||||:||||||||||||||||||||||||.|.||:..|:|..|.
Mouse     5 LTAREIRERFINFFRRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMAKLSRA 69

  Fly    69 ANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLTQRLALPKDRLY 133
            |||||||||||||||||||||||||||||||||:||||||||:..|..|.|.|||...:|.:|||
Mouse    70 ANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIPVERLY 134

  Fly   134 VTYFGGDAASGLEPDLECKQMWLDLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDRIGGRS 198
            |||||||.|:||||||||:|:|.:|||....||||:|||||||||:|||||||||:|:||||||.
Mouse   135 VTYFGGDEAAGLEPDLECRQIWQNLGLDEARILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRD 199

  Fly   199 VPELVNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYDTDLFV 263
            ...|||.|||:||||||||||||||||||.||.||||.||.|||.||||||:|||.||||||||:
Mouse   200 AAHLVNQDDPNVLEIWNLVFIQYNRESDGVLKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFM 264

  Fly   264 PLFDAIQAGTGAPPYQGRVGADDVDGIDMAYRVLADHARTITIALADGGTPDNTGRGYVLRRILR 328
            |.|:|||.||||.||.|:|||:|.||||||||||||||||||:||||||.|||||||||||||||
Mouse   265 PYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVLADHARTITVALADGGRPDNTGRGYVLRRILR 329

  Fly   329 RAVRYATEKLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGRNLLN 393
            |||||:.|||||..|||||||:.||..|||||||:||||:.:.|||||||:||||||:|||.:|:
Mouse   330 RAVRYSHEKLNASRGFFATLVDVVVQSLGDAFPELKKDPEMVKDIINEEEVQFLKTLSRGRRILD 394

  Fly   394 RTIEKLGNQTTIPGDVAWRLYDTYGFPVDLTQLMAEEKSLKIDMDGYEAAKHNSYVLSQGKGASK 458
            |.|:.||:..|||||.||.||||||||||||.|:||||.|.:||:|:|..:..:.:.||||||..
Mouse   395 RKIQSLGDCKTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMNGFEEERRLAQLKSQGKGAGD 459

  Fly   459 IEEINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSAYNYGVCNSKIVALRFENQFVNEITS 523
            .:.|.||::||.:|:.:|:..|:|:.||.|::   :...:|.:....:.::|||.|..||:|:.:
Mouse   460 EDLIMLDIYAIEELRAKGLEATDDSPKYNYQS---DSSGSYVFECTVATVLALRREKMFVDEVVT 521

  Fly   524 GQKAGIVLDKTNFYAESGGQIYDQGALVKVND---EANEFLVDRVYNRGGYILHIGVVEGTLKVG 585
            ||:.|:|||||.||||.||||||:|.||||:|   :..||.|.....||||:||||.:.|.||||
Mouse   522 GQECGVVLDKTCFYAEQGGQIYDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYGNLKVG 586

  Fly   586 DELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMTIEQVS 650
            |::.|.||..||...|.||:|||.||..|..||| :.:||||||.|::|||||.:|.||:.:|:.
Mouse   587 DQVRLFIDEPRRRPVMSNHTATHILNFALRSVLG-EADQKGSLVAPDRLRFDFTAKGAMSTQQIK 650

  Fly   651 KTEQLTKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPDPVRVISFGVPVDELEQNPDSEAG 715
            |.|::...|:....|:|.::..||.||.|:|||:||||.|||||||:|.||||.||..:|...||
Mouse   651 KAEEIVNGMIEAAKPVYTQDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVSELLDDPCGPAG 715

  Fly   716 EQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSEAFEQEIVRLKAT 780
            ..||||||||||||.|.|...|||.:|||||||||||||:||.||.|||:|||..::.:..::|.
Mouse   716 SLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKSETLKKSLSAMEAK 780

  Fly   781 IDNDKSGKDSKSHVKEIVELTEQISHATIPYVKKDEMRNLLKGLKKTLDDKERALRAAVSVTVVE 845
            :....:  .:|...:||.:|.|.::.|.||..:|||.|..||.|||.:||.:||.:|.|...|:|
Mouse   781 VKAQTA--PNKDVQREIADLGEALATAVIPQWQKDEQRETLKSLKKVMDDLDRASKADVQKRVLE 843

  Fly   846 RAKTLCEANPNATVLVEQLEAFNNTKALDAALKQVRSQLPDAAAMFLSVDADSKKIFCLSSVPKS 910
            :.|.|.::|||..:::.::|:..:.|||:.|||..::..|..:||..:||.::.||.||..||::
Mouse   844 KTKQLIDSNPNQPLVILEMESGASAKALNEALKLFKTHSPQTSAMLFTVDNEAGKITCLCQVPQN 908

  Fly   911 AVEKGLKANEWVQHVSATLGGKGGGKPESAQASGTNYEKVDEIVQLASKFAQSKL 965
            |..:||||:||||.||..:.||||||..||||:|.|...:.|.:|||:.|||.:|
Mouse   909 AANRGLKASEWVQQVSGLMDGKGGGKDMSAQATGKNVGCLQEALQLATSFAQLRL 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	582/960 (61%)
Aars1	NP_666329.2	PLN02900	6..961	CDD:215487	582/960 (61%)
		Nuclear localization signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03133	750..763		9/12 (75%)