DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AlaRS and Aars

DIOPT Version :9

Sequence 1:	NP_523511.2	Gene:	AlaRS / 34156	FlyBaseID:	FBgn0027094	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_666329.2	Gene:	Aars / 234734	MGIID:	2384560	Length:	968	Species:	Mus musculus

Alignment Length:	965	Identity:	585/965 - (60%)
Similarity:	727/965 - (75%)	Gaps:	9/965 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LTAKEVRNAYLDFFKEQKHIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSKWVRV 68
            |||:|:|..:::||:..:|.|||||:||||||||||||||||||||||||.|.||:..|:|..|.
Mouse     5 LTAREIRERFINFFRRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMAKLSRA 69

  Fly    69 ANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLTQRLALPKDRLY 133
            |||||||||||||||||||||||||||||||||:||||||||:..|..|.|.|||...:|.:|||
Mouse    70 ANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIPVERLY 134

  Fly   134 VTYFGGDAASGLEPDLECKQMWLDLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDRIGGRS 198
            |||||||.|:||||||||:|:|.:|||....||||:|||||||||:|||||||||:|:||||||.
Mouse   135 VTYFGGDEAAGLEPDLECRQIWQNLGLDEARILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRD 199

  Fly   199 VPELVNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYDTDLFV 263
            ...|||.|||:||||||||||||||||||.||.||||.||.|||.||||||:|||.||||||||:
Mouse   200 AAHLVNQDDPNVLEIWNLVFIQYNRESDGVLKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFM 264

  Fly   264 PLFDAIQAGTGAPPYQGRVGADDVDGIDMAYRVLADHARTITIALADGGTPDNTGRGYVLRRILR 328
            |.|:|||.||||.||.|:|||:|.||||||||||||||||||:||||||.|||||||||||||||
Mouse   265 PYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVLADHARTITVALADGGRPDNTGRGYVLRRILR 329

  Fly   329 RAVRYATEKLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGRNLLN 393
            |||||:.|||||..|||||||:.||..|||||||:||||:.:.|||||||:||||||:|||.:|:
Mouse   330 RAVRYSHEKLNASRGFFATLVDVVVQSLGDAFPELKKDPEMVKDIINEEEVQFLKTLSRGRRILD 394

  Fly   394 RTIEKLGNQTTIPGDVAWRLYDTYGFPVDLTQLMAEEKSLKIDMDGYEAAKHNSYVLSQGKGASK 458
            |.|:.||:..|||||.||.||||||||||||.|:||||.|.:||:|:|..:..:.:.||||||..
Mouse   395 RKIQSLGDCKTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMNGFEEERRLAQLKSQGKGAGD 459

  Fly   459 IEEINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSAYNYGVCNSKIVALRFENQFVNEITS 523
            .:.|.||::||.:|:.:|:..|:|:.||.|::   :...:|.:....:.::|||.|..||:|:.:
Mouse   460 EDLIMLDIYAIEELRAKGLEATDDSPKYNYQS---DSSGSYVFECTVATVLALRREKMFVDEVVT 521

  Fly   524 GQKAGIVLDKTNFYAESGGQIYDQGALVKVND---EANEFLVDRVYNRGGYILHIGVVEGTLKVG 585
            ||:.|:|||||.||||.||||||:|.||||:|   :..||.|.....||||:||||.:.|.||||
Mouse   522 GQECGVVLDKTCFYAEQGGQIYDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYGNLKVG 586

  Fly   586 DELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMTIEQVS 650
            |::.|.||..||...|.||:|||.||..|..||| :.:||||||.|::|||||.:|.||:.:|:.
Mouse   587 DQVRLFIDEPRRRPVMSNHTATHILNFALRSVLG-EADQKGSLVAPDRLRFDFTAKGAMSTQQIK 650

  Fly   651 KTEQLTKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPDPVRVISFGVPVDELEQNPDSEAG 715
            |.|::...|:....|:|.::..||.||.|:|||:||||.|||||||:|.||||.||..:|...||
Mouse   651 KAEEIVNGMIEAAKPVYTQDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVSELLDDPCGPAG 715

  Fly   716 EQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSEAFEQEIVRLKAT 780
            ..||||||||||||.|.|...|||.:|||||||||||||:||.||.|||:|||..::.:..::|.
Mouse   716 SLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKSETLKKSLSAMEAK 780

  Fly   781 IDNDKSGKDSKSHVKEIVELTEQISHATIPYVKKDEMRNLLKGLKKTLDDKERALRAAVSVTVVE 845
            :....:  .:|...:||.:|.|.::.|.||..:|||.|..||.|||.:||.:||.:|.|...|:|
Mouse   781 VKAQTA--PNKDVQREIADLGEALATAVIPQWQKDEQRETLKSLKKVMDDLDRASKADVQKRVLE 843

  Fly   846 RAKTLCEANPNATVLVEQLEAFNNTKALDAALKQVRSQLPDAAAMFLSVDADSKKIFCLSSVPKS 910
            :.|.|.::|||..:::.::|:..:.|||:.|||..::..|..:||..:||.::.||.||..||::
Mouse   844 KTKQLIDSNPNQPLVILEMESGASAKALNEALKLFKTHSPQTSAMLFTVDNEAGKITCLCQVPQN 908

  Fly   911 AVEKGLKANEWVQHVSATLGGKGGGKPESAQASGTNYEKVDEIVQLASKFAQSKL 965
            |..:||||:||||.||..:.||||||..||||:|.|...:.|.:|||:.|||.:|
Mouse   909 AANRGLKASEWVQQVSGLMDGKGGGKDMSAQATGKNVGCLQEALQLATSFAQLRL 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	582/960 (61%)
		AlaRS_core	6..253	CDD:238360	184/246 (75%)
		tRNA_SAD	529..>626	CDD:298782	56/99 (57%)
		tRNA_SAD	694..752	CDD:285247	39/57 (68%)
		DHHA1	888..957	CDD:280440	35/68 (51%)
Aars	NP_666329.2	PLN02900	6..961	CDD:215487	582/960 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838880
Domainoid	1	1.000	823	1.000	Domainoid score	I61
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1213
Inparanoid	1	1.050	1168	1.000	Inparanoid score	I202
Isobase	1	0.950	-	0	Normalized mean entropy	S431
OMA	1	1.010	-	-		QHG60684
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001295
OrthoInspector	1	1.000	-	-		oto94784
orthoMCL	1	0.900	-	-		OOG6_100414
Panther	1	1.100	-	-	LDO	PTHR11777
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1429
SonicParanoid	1	1.000	-	-		X999
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740