Protein Alignment AlaRS and aars-2

DIOPT Version :10

• Sequence 1: NP_523511.2
• Gene: AlaRS / 34156
• FlyBaseID: FBgn0027094
• Length: 966
• Species: Drosophila melanogaster
• Sequence 2: NP_491281.1
• Gene: aars-2 / 171985
• WormBaseID: WBGene00000197
• Length: 968
• Species: Caenorhabditis elegans
• Alignment Length: 980
• Identity: 544/980 - (55%)
• Similarity: 708/980 - (72%)
• Gaps: 26/980 - (2%)

  Fly     1 MKLLTAKEVRNAYLDFFKEQK-HIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSK 64
            ||.|||.|||:.:::||:|:| |.||||||.||.|||||||||||||||||:|||.|||||:::|
 Worm     1 MKHLTASEVRSTFINFFREKKEHTYVHSSSVIPHDDPTLLFANAGMNQFKPLFLGIADPNSDLAK 65

  Fly    65 WVRVANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLTQRLALPK 129
            ..|..||||||||||||||||||||||||||:|||||||||||||||||.:||||.||....:|.
 Worm    66 LKRAVNTQKCIRAGGKHNDLDDVGKDVYHHTYFEMLGNWSFGDYFKKEIITWAWELLTTVYGIPA 130

  Fly   130 DRLYVTYFGGDAASGLEPDLECKQMWLDLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDRI 194
            :||||:.||||.|:|:..|.|.:.:|..:|:..|.||...|||||||||:.||||||||:|:|||
 Worm   131 ERLYVSVFGGDEANGVPADSEARDIWRSVGVPDERILNFGMKDNFWEMGDVGPCGPCSEIHYDRI 195

  Fly   195 GGRSVPELVNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYDT 259
            |.|....|||.|||.|:|||||||||:|||..|.||.||.||||||:|.|||::|:|:|.|||||
 Worm   196 GNRDASHLVNADDPMVVEIWNLVFIQFNREEGGVLKPLPAKHIDCGLGLERLIAVMQDKTSNYDT 260

  Fly   260 DLFVPLFDAIQAGTGAPPYQGRVGADDVDGIDMAYRVLADHARTITIALADGGTPDNTGRGYVLR 324
            |:|.|:|:||..|:|...|.|.:|.:|.||:||||||:|||.||:||||:|||.|||:|||||||
 Worm   261 DIFQPIFEAIHKGSGVRAYTGFIGDEDKDGVDMAYRVVADHVRTLTIALSDGGRPDNSGRGYVLR 325

  Fly   325 RILRRAVRYATEKLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGR 389
            |||||.||||:|||||:|||||:||..|:.:||:.|||:.:||..::||||:||.||||||:|||
 Worm   326 RILRRGVRYASEKLNAQPGFFASLVPVVISILGETFPELSRDPVTVMDIINDEEKQFLKTLSRGR 390

  Fly   390 NLLNRTIEKLGNQT-TIPGDVAWRLYDTYGFPVDLTQLMAEEKSLKIDMDGYEAAKHNSYVLSQG 453
            .|..|.::.|...| |.||||:||||||||||.||||||||||.|.:|...:|.|:..: :.:..
 Worm   391 VLFQRAVQSLPEGTMTFPGDVSWRLYDTYGFPADLTQLMAEEKGLSVDNTAFEEARRKA-IETSS 454

  Fly   454 KGASKIEE-INLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSAYNYGVCNSKIVALRFENQF 517
            .|..|..: ::|||||:::||::|||.|:|:.||.|....:..|:.|.:..|..||:|:|.:.:|
 Worm   455 AGTGKFRDTLDLDVHALAELQQKGVPTTDDSPKYAYTFTGEGSDAVYKFEPCVGKILAIRRDGKF 519

  Fly   518 VNEITSGQKAGIVLDKTNFYAESGGQIYDQGALVKVNDEANEFLVDRVYNRGGYILHIGVVEGTL 582
            |:::.:|::..|:||:||||||.||||||.|.|.|||||:|||.|.....|||||:.:|..||:.
 Worm   520 VDQLAAGEEGAILLDRTNFYAEQGGQIYDVGVLTKVNDESNEFNVSNCQVRGGYIVLVGSAEGSF 584

  Fly   583 KVGDELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMTIE 647
            .|||::....|.:|:.|.||||:.||.||:.|.:||. |::||||||.|:::||||.:||.||::
 Worm   585 SVGDQVNERFDEDRKQLIMKNHTGTHVLNYALRKVLA-DSDQKGSLVAPDRMRFDFTNKAGMTVQ 648

  Fly   648 QVSKTEQLTKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPDPVRVISFGVPVDELEQNPDS 712
            ||.|.|:..::::.....:|||.|.|..|||::|||::|||.|||||||::.|.||::|.||||:
 Worm   649 QVKKAEEYAQQLIDTKGQVYAKNSPLGEAKKVKGLRAMFDETYPDPVRVVAVGTPVEQLLQNPDA 713

  Fly   713 EAGEQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSEAFEQEIVRL 777
            |.|:.|:|||||||||:...||...||:||||||||||||||||||||.:|:.:::       ||
 Worm   714 EEGQNTTVEFCGGTHLQNVSHIGRIVIASEEAIAKGIRRIVALTGPEAERAIARAD-------RL 771

  Fly   778 KATIDNDKSGKDSKSHV-----------KEIVELTEQISHATIPYVKKDEMRNLLKGLKKTLDDK 831
            .|.::.:....|.|..:           |:|.|:.::.:.|.:||.:||.:|...|.::||||..
 Worm   772 TARLEEESKHADKKDELLANKDKFKALQKKIQEIVDEANGAQLPYWRKDSIREKAKAIQKTLDGY 836

  Fly   832 ERALRAAVSVTVVERAKTLCEANPNATVLVEQLEAFNNTKALDAALKQVRSQLPDAAAMFLSVDA 896
            .:|.:|||:..|:..||.|.......||||....|..|:||:|.|||.::.   ..|.|..||:.
 Worm   837 TKAQQAAVAEKVLGEAKELAAVAEQPTVLVHVFAANANSKAIDNALKLLKD---TKAVMAFSVNE 898

  Fly   897 DSKKIFCLSSVPKSAVEKGLKANEWVQHVSATLGGKGGGKPESAQASGTNYEKVDEIVQLASKFA 961
            ||.|:.||:.|.||.|..||||||||..|...||||||||..:||.:|.|.:|:|..|:||.|||
 Worm   899 DSGKVLCLAKVDKSLVSNGLKANEWVNEVCTVLGGKGGGKDANAQLTGENVDKLDAAVELAQKFA 963

  Fly   962 QSKLS 966
            .:.::
 Worm   964 LAAIN 968

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	541/971 (56%)
aars-2	NP_491281.1	PLN02900	5..965	CDD:215487	541/971 (56%)