Protein Alignment AlaRS and AARS1

DIOPT Version :10

• Sequence 1: NP_523511.2
• Gene: AlaRS / 34156
• FlyBaseID: FBgn0027094
• Length: 966
• Species: Drosophila melanogaster
• Sequence 2: NP_001596.2
• Gene: AARS1 / 16
• HGNCID: 20
• Length: 968
• Species: Homo sapiens
• Alignment Length: 967
• Identity: 590/967 - (61%)
• Similarity: 724/967 - (74%)
• Gaps: 13/967 - (1%)

  Fly     4 LTAKEVRNAYLDFFKEQKHIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSKWVRV 68
            |||.|:|..::||||..:|.|||||:||||||||||||||||||||||||.|.||:..|:|..|.
Human     5 LTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMAKLSRA 69

  Fly    69 ANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLTQRLALPKDRLY 133
            |||||||||||||||||||||||||||||||||:||||||||:..|..|.|.|||...:|.:|||
Human    70 ANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIPIERLY 134

  Fly   134 VTYFGGDAASGLEPDLECKQMWLDLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDRIGGRS 198
            |||||||.|:|||.||||||:|.:|||....||||:|||||||||:|||||||||:|:||||||.
Human   135 VTYFGGDEAAGLEADLECKQIWQNLGLDDTKILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRD 199

  Fly   199 VPELVNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYDTDLFV 263
            ...|||.|||:|||||||||||||||:||.||.||||.||.|||.||||||:|||.|||||||||
Human   200 AAHLVNQDDPNVLEIWNLVFIQYNREADGILKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFV 264

  Fly   264 PLFDAIQAGTGAPPYQGRVGADDVDGIDMAYRVLADHARTITIALADGGTPDNTGRGYVLRRILR 328
            |.|:|||.||||.||.|:|||:|.||||||||||||||||||:||||||.|||||||||||||||
Human   265 PYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVLADHARTITVALADGGRPDNTGRGYVLRRILR 329

  Fly   329 RAVRYATEKLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGRNLLN 393
            ||||||.|||||..|||||||:.||..|||||||:||||..:.|||||||:||||||:|||.:|:
Human   330 RAVRYAHEKLNASRGFFATLVDVVVQSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSRGRRILD 394

  Fly   394 RTIEKLGNQTTIPGDVAWRLYDTYGFPVDLTQLMAEEKSLKIDMDGYEAAKHNSYVLSQGKGASK 458
            |.|:.||:..|||||.||.||||||||||||.|:||||.|.:||||:|..:..:.:.||||||..
Human   395 RKIQSLGDSKTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMDGFEEERKLAQLKSQGKGAGG 459

  Fly   459 IEEINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSAYNYGVCN--SKIVALRFENQFVNEI 521
            .:.|.||::||.:|:.:|:..|:|:.||.|..     ||:.:|...|  :.::|||.|..||.|:
Human   460 EDLIMLDIYAIEELRARGLEVTDDSPKYNYHL-----DSSGSYVFENTVATVMALRREKMFVEEV 519

  Fly   522 TSGQKAGIVLDKTNFYAESGGQIYDQGALVKVND---EANEFLVDRVYNRGGYILHIGVVEGTLK 583
            ::||:.|:|||||.||||.||||||:|.||||:|   :..||.|.....||||:||||.:.|.||
Human   520 STGQECGVVLDKTCFYAEQGGQIYDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYGDLK 584

  Fly   584 VGDELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMTIEQ 648
            |||::.|.||..||...|.||:|||.||..|..||| :.:||||||.|::|||||.:|.||:.:|
Human   585 VGDQVWLFIDEPRRRPIMSNHTATHILNFALRSVLG-EADQKGSLVAPDRLRFDFTAKGAMSTQQ 648

  Fly   649 VSKTEQLTKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPDPVRVISFGVPVDELEQNPDSE 713
            :.|.|::..||:.....:|.::..||.||.|:|||:||||.|||||||:|.||||.||..:|...
Human   649 IKKAEEIANEMIEAAKAVYTQDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVSELLDDPSGP 713

  Fly   714 AGEQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSEAFEQEIVRLK 778
            ||..||||||||||||.|.|...|||.:|||||||||||||:||.||.|||:|:|:.::.:..::
Human   714 AGSLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKAESLKKCLSVME 778

  Fly   779 ATIDNDKSGKDSKSHVKEIVELTEQISHATIPYVKKDEMRNLLKGLKKTLDDKERALRAAVSVTV 843
            |.:....:  .:|...:||.:|.|.::.|.||..:|||:|..||.|||.:||.:||.:|.|...|
Human   779 AKVKAQTA--PNKDVQREIADLGEALATAVIPQWQKDELRETLKSLKKVMDDLDRASKADVQKRV 841

  Fly   844 VERAKTLCEANPNATVLVEQLEAFNNTKALDAALKQVRSQLPDAAAMFLSVDADSKKIFCLSSVP 908
            :|:.|...::|||..:::.::|:..:.|||:.|||..:...|..:||..:||.::.||.||..||
Human   842 LEKTKQFIDSNPNQPLVILEMESGASAKALNEALKLFKMHSPQTSAMLFTVDNEAGKITCLCQVP 906

  Fly   909 KSAVEKGLKANEWVQHVSATLGGKGGGKPESAQASGTNYEKVDEIVQLASKFAQSKL 965
            ::|..:||||:||||.||..:.||||||..||||:|.|...:.|.:|||:.|||.:|
Human   907 QNAANRGLKASEWVQQVSGLMDGKGGGKDVSAQATGKNVGCLQEALQLATSFAQLRL 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	587/962 (61%)
AARS1	NP_001596.2	PLN02900	6..961	CDD:215487	587/962 (61%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:38512451	750..763		9/12 (75%)