DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AlaRS and aars2

DIOPT Version :9

Sequence 1:	NP_523511.2	Gene:	AlaRS / 34156	FlyBaseID:	FBgn0027094	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	XP_031758200.1	Gene:	aars2 / 101731300	XenbaseID:	XB-GENE-6251328	Length:	983	Species:	Xenopus tropicalis

Alignment Length:	968	Identity:	454/968 - (46%)
Similarity:	632/968 - (65%)	Gaps:	29/968 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VRNAYLDFFKEQK-HIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNSEMSKWVRVANTQ 72
            :|.|:|.:|:|:. |.:|.|||..|..||:|||.|||||||||:||||.||.|:|:::.||||:|
Frog    34 IRRAFLRYFQEKHGHRHVPSSSVRPRGDPSLLFVNAGMNQFKPMFLGTVDPRSDMAQYRRVANSQ 98

  Fly    73 KCIRAGGKHNDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLTQRLALPKDRLYVTYF 137
            ||:|||||||||:|||:|||||||||||||||||||||:|.||.|||.||:...:|..|||||||
Frog    99 KCVRAGGKHNDLEDVGRDVYHHTFFEMLGNWSFGDYFKEEACSMAWELLTRGYGIPAHRLYVTYF 163

  Fly   138 GGDAASGLEPDLECKQMWLDLGLKPEHILPGSMKDNFWEMGETGPCGPCSELHFDRIGGRSVPEL 202
            |||.|.||.||.|.:::||.||:.|..|||..:::||||||||||||||:|:|:|.:|||....|
Frog   164 GGDPALGLSPDRETQEIWLSLGVPPARILPFGLRENFWEMGETGPCGPCTEIHYDHLGGRDAASL 228

  Fly   203 VNMDDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYDTDLFVPLFD 267
            ||.|.|||:|||||||:|||||:||||:.||::|:|.|||.||||||:|.||||||||||.|:.:
Frog   229 VNRDCPDVVEIWNLVFMQYNRETDGSLRLLPQRHVDTGMGLERLVSVLQGKRSNYDTDLFSPILE 293

  Fly   268 AIQAGTGAPPYQGRVGADDVDGIDMAYRVLADHARTITIALADGGTPDNTGRGYVLRRILRRAVR 332
            ||..|:|||.|:|.:|.:|....||||||:|||.||:.:.:|||..|..:|...|||||||||||
Frog   294 AIMKGSGAPRYRGLLGKEDAGHTDMAYRVVADHIRTLCVCIADGVYPGMSGTELVLRRILRRAVR 358

  Fly   333 YATEKLNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGRNLLNRTIE 397
            :::|.|.|.|.|.::||.:|||:||:||||::::...|::|:||.|..||.:|.|||.::.||::
Frog   359 FSSEILRAPPHFLSSLVPSVVDVLGEAFPELEREKSQIMNILNENEEAFLASLQRGRRIIERTLQ 423

  Fly   398 KLGNQTTIPGDVAWRLYDTYGFPVDLTQLMAEEKSLKIDMDGYE--AAKHNSYVLSQGKGASKIE 460
            :.....|.|..|||.|:...|||:||..||.||:.:.:|....:  ||:.....:...:......
Frog   424 QEEEPQTFPVGVAWSLHRNLGFPLDLIGLMLEERGISLDKAALDHLAAEEAERKMKNQQADEAQT 488

  Fly   461 EINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSAYNYGVCNSKIVALRFENQFVNEITSGQ 525
            .:.||||::::||.:|||.|||:.||.|...:|.:   |.:|.|.:.::.|..::....||.:||
Frog   489 GLELDVHSLAELQRRGVPCTNDSPKYDYTLGADGK---YVFGPCRATVLTLYKDHSLHCEIAAGQ 550

  Fly   526 KAGIVLDKTNFYAESGGQIYDQGALVKVNDEANEFLVDRVYNRGGYILHIGVVEGTLKVGDELEL 590
            :.|:|||:|.||||.|||..|||..|:...:...|.|:.|...|||::|.......|:|||.:.|
Frog   551 RCGVVLDRTCFYAEQGGQSCDQGYFVREEQQEALFPVESVQVAGGYVIHEVTTAEVLRVGDRVAL 615

  Fly   591 HIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMTIEQVSKTEQL 655
            ::|...|...|:.|||||.||..|.:|||::|||:||.|..|:||||.:..|.:.:||:.:.||.
Frog   616 YLDEAHRLACMQKHSATHLLNFALRRVLGENTEQRGSHVTAERLRFDASVTAPVRMEQLQEVEQT 680

  Fly   656 TKEMVYKNVPIYAKESKLALAKKIRGLRSVFDEVYPDPVRVISFGVPVDELEQNPDSEAGEQTSV 720
            .::::.::..|:.....||.||.:||||:| ||.||:||||:|..:|:.| ...|.|:|..||||
Frog   681 LQDVISQDGEIHTALVPLAEAKCVRGLRTV-DEPYPNPVRVVSVALPIQE-AMRPGSQAALQTSV 743

  Fly   721 EFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSE----AFEQEIVRLKATI 781
            |.|.||||..:|.|.|.||.||..:||||.|::|:||.||.:|.:..:    |.|....|:|
Frog   744 ELCCGTHLLTTGAIQDVVIVSERPLAKGITRLIAVTGEEAKQAREAGQELAGAVESVTERMK--- 805

  Fly   782 DNDKSGKDSKSHVKEIVELTEQISHATIPYVKKDEMRNLLKGLKKTLDDKERAL---RAAVSVTV 843
            ....|..:.....||:..||:.:..||:|..::.|::..||.|::..:...|.|   :|||
Frog   806 PKPLSLNEGFRLSKEVGILTDSVDSATMPQWQRKELQARLKALQRAANTNIRKLELQQAAV---- 866

  Fly   844 VERAKTLCEANPNATVLVEQLEAFNNTKALDAALKQVRSQLPDAAAMFLSVDADSKKIFCLSSVP 908
              ||:.|.:.:...::::|::.| .:...|...:.||....|.||.|.|| ..||.|:||...||
Frog   867 --RAQGLLKKHSQCSLIIEEVSA-ESLSMLVKVVNQVSDGAPGAAVMLLS-KQDSGKVFCACQVP 927

  Fly   909 KSAVEKGLKANEWVQHVSATLGGKGGGKPESAQASGTNYEKVDEIVQLASKFAQSKLS 966
            |.:..: |.|.||...|.:.:||..||....|:.:||. :.::.::|.|..||| |:|
Frog   928 KGSGSE-LSAAEWATAVCSAMGGNAGGSDVVAKGTGTT-DSLERVLQTAQNFAQ-KMS 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS	NP_523511.2	PLN02900	5..963	CDD:215487	451/963 (47%)
		AlaRS_core	6..253	CDD:238360	163/244 (67%)
		tRNA_SAD	529..>626	CDD:298782	44/96 (46%)
		tRNA_SAD	694..752	CDD:285247	30/57 (53%)
		DHHA1	888..957	CDD:280440	25/68 (37%)
aars2	XP_031758200.1	PLN02900	32..979	CDD:215487	450/962 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129373at2759
OrthoFinder	1	1.000	-	-		FOG0001295
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X999
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010