DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr82 and SWD2

DIOPT Version :9

Sequence 1:	NP_609217.1	Gene:	Wdr82 / 34153	FlyBaseID:	FBgn0032030	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_012907.3	Gene:	SWD2 / 853851	SGDID:	S000001501	Length:	329	Species:	Saccharomyces cerevisiae

Alignment Length:	328	Identity:	116/328 - (35%)
Similarity:	169/328 - (51%)	Gaps:	45/328 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FKVAKIFR---ENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFT 74
            ||..|.|:   ::...:.:::|..||:.|::.|.:|.:.:|.........|:.|||||.....||
Yeast    14 FKHVKSFQPQEKDCGPVTSLNFDDNGQFLLTSSSNDTMQLYSATNCKFLDTIASKKYGCHSAIFT 78

  Fly    75 HANNTAIHSSTKVDDTIRYLSLHDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKTLRLWDLR 139
            ||.|..|:|||..:..|:||:|..|:|||||.||...|..|.::||.|||||.|.|:::|||||:
Yeast    79 HAQNECIYSSTMKNFDIKYLNLETNQYLRYFSGHGALVNDLKMNPVNDTFLSSSYDESVRLWDLK 143

  Fly   140 -----------SPNCQGLMHLSGRPIAAYDPEGLIFAAGVNSES--IKLYDLRSFDKGPFVTFKL 191
                       .|||           .||||.||:||.| |.|:  |.||:|:...:|||:..|:
Yeast   144 ISKPQVIIPSLVPNC-----------IAYDPSGLVFALG-NPENFEIGLYNLKKIQEGPFLIIKI 196

  Fly   192 NQEKECDWTGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPNNKGIPI-------EASF 249
            |......|..|:||.:||.:|:.::.....:.|||.|..|....|   .:..|:       .|.|
Yeast   197 NDATFSQWNKLEFSNNGKYLLVGSSIGKHLIFDAFTGQQLFELIG---TRAFPMREFLDSGSACF 258

  Fly   250 SPDSQFIFSGSTDGRVHIWN-ADT-GNKVSVLNG-----DHPGPVQCVQFNPKYMMLASACTNMA 307
            :||.:|:.....|||:.||| :|: .|||....|     .|....:.:.|||||.|..:|...:.
Yeast   259 TPDGEFVLGTDYDGRIAIWNHSDSISNKVLRPQGFIPCVSHETCPRSIAFNPKYSMFVTADETVD 323

  Fly   308 FWL 310
            |::
Yeast   324 FYV 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr82	NP_609217.1	WD40	17..302	CDD:238121	112/314 (36%)
		WD40 repeat	26..63	CDD:293791	8/36 (22%)
		WD40 repeat	69..107	CDD:293791	19/37 (51%)
		WD40 repeat	112..150	CDD:293791	19/48 (40%)
		WD40 repeat	155..192	CDD:293791	19/38 (50%)
		WD40 repeat	199..235	CDD:293791	12/35 (34%)
		WD40 repeat	243..280	CDD:293791	16/45 (36%)
		WD40 repeat	287..309	CDD:293791	7/21 (33%)
SWD2	NP_012907.3	WD40	28..322	CDD:421866	111/308 (36%)
		WD40 repeat	30..72	CDD:293791	12/41 (29%)
		WD40 repeat	78..111	CDD:293791	18/32 (56%)
		WD40 repeat	116..152	CDD:293791	16/35 (46%)
		WD40 repeat	157..197	CDD:293791	21/51 (41%)
		WD40 repeat	204..240	CDD:293791	12/35 (34%)
		WD40 repeat	247..294	CDD:293791	16/46 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343264
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1446
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H42951
Inparanoid	1	1.050	180	1.000	Inparanoid score	I962
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54522
OrthoFinder	1	1.000	-	-		FOG0002456
OrthoInspector	1	1.000	-	-		otm46744
orthoMCL	1	0.900	-	-		OOG6_102214
Panther	1	1.100	-	-	LDO	PTHR19861
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1421
SonicParanoid	1	1.000	-	-		X1869
TreeFam	1	0.960	-	-
	14	13.790