DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr82 and wdr82

DIOPT Version :9

Sequence 1:	NP_609217.1	Gene:	Wdr82 / 34153	FlyBaseID:	FBgn0032030	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_001159740.1	Gene:	wdr82 / 321614	ZFINID:	ZDB-GENE-030131-333	Length:	313	Species:	Danio rerio

Alignment Length:	313	Identity:	215/313 - (68%)
Similarity:	268/313 - (85%)	Gaps:	0/313 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IKLIDSVVRSFKVAKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYG 67
            :||.|||:|||:|||:||||:||||..||:.|||.:||.|:||.||:|||::|...||:.|||||
Zfish     1 MKLTDSVLRSFRVAKVFRENSDKINCFDFSSNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYG 65

  Fly    68 VDLIHFTHANNTAIHSSTKVDDTIRYLSLHDNKYLRYFPGHTKKVISLCISPVEDTFLSGSLDKT 132
            ||||.:|||.||.::||.|:||||||||||||||:||||||.|:|::|.:|||:|||:|||||||
Zfish    66 VDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRYFPGHNKRVVALSMSPVDDTFISGSLDKT 130

  Fly   133 LRLWDLRSPNCQGLMHLSGRPIAAYDPEGLIFAAGVNSESIKLYDLRSFDKGPFVTFKLNQEKEC 197
            :||||||||||||||||.|:|:.::||||||||||||||.:|||||||||||||.||||..|:.|
Zfish   131 IRLWDLRSPNCQGLMHLQGKPVCSFDPEGLIFAAGVNSEMVKLYDLRSFDKGPFATFKLQYERTC 195

  Fly   198 DWTGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPNNKGIPIEASFSPDSQFIFSGSTD 262
            :|||||||.|||.||:||||..:|::|||.|..|.:|.||.|:||:.:||||:||||||..||.|
Zfish   196 EWTGLKFSNDGKLILVSTNGGTLRVLDAFKGAVLHSFGGYNNSKGVILEASFTPDSQFIMIGSED 260

  Fly   263 GRVHIWNADTGNKVSVLNGDHPGPVQCVQFNPKYMMLASACTNMAFWLPTSEE 315
            |::|:|||::|.||::|:|.|.|||.|:|||||:|..||||:||||||||.::
Zfish   261 GKIHVWNAESGMKVALLDGKHTGPVTCLQFNPKFMTFASACSNMAFWLPTIDD 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr82	NP_609217.1	WD40	17..302	CDD:238121	194/284 (68%)
		WD40 repeat	26..63	CDD:293791	20/36 (56%)
		WD40 repeat	69..107	CDD:293791	28/37 (76%)
		WD40 repeat	112..150	CDD:293791	30/37 (81%)
		WD40 repeat	155..192	CDD:293791	30/36 (83%)
		WD40 repeat	199..235	CDD:293791	22/35 (63%)
		WD40 repeat	243..280	CDD:293791	21/36 (58%)
		WD40 repeat	287..309	CDD:293791	15/21 (71%)
wdr82	NP_001159740.1	WD40	<10..303	CDD:225201	201/292 (69%)
		WD40	15..300	CDD:238121	194/284 (68%)
		WD 1	19..58		22/38 (58%)
		WD40 repeat	24..61	CDD:293791	20/36 (56%)
		WD40 repeat	67..105	CDD:293791	28/37 (76%)
		WD 2	105..144		29/38 (76%)
		WD40 repeat	110..148	CDD:293791	30/37 (81%)
		WD 3	146..184		29/37 (78%)
		WD40 repeat	153..190	CDD:293791	30/36 (83%)
		WD 4	192..231		24/38 (63%)
		WD40 repeat	197..233	CDD:293791	22/35 (63%)
		WD 5	237..276		24/38 (63%)
		WD40 repeat	241..282	CDD:293791	23/40 (58%)
		WD 6	280..313		23/32 (72%)
		WD40 repeat	285..307	CDD:293791	15/21 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579040
Domainoid	1	1.000	154	1.000	Domainoid score	I4236
eggNOG	1	0.900	-	-		E1_KOG1446
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H42951
Inparanoid	1	1.050	480	1.000	Inparanoid score	I1433
OMA	1	1.010	-	-		QHG54522
OrthoDB	1	1.010	-	-		D1146727at2759
OrthoFinder	1	1.000	-	-		FOG0002456
OrthoInspector	1	1.000	-	-		oto41358
orthoMCL	1	0.900	-	-		OOG6_102214
Panther	1	1.100	-	-	LDO	PTHR19861
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1421
SonicParanoid	1	1.000	-	-		X1869
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800