DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr82 and swd-2.1

DIOPT Version :9

Sequence 1:	NP_609217.1	Gene:	Wdr82 / 34153	FlyBaseID:	FBgn0032030	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_501281.2	Gene:	swd-2.1 / 183186	WormBaseID:	WBGene00016373	Length:	322	Species:	Caenorhabditis elegans

Alignment Length:	315	Identity:	109/315 - (34%)
Similarity:	178/315 - (56%)	Gaps:	7/315 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KLIDSVVRSFKV---AKIFRENTDKINAIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKK 65
            :||.....:||.   :|.|.|.::|:..:.::.:|.:|| .|.:|.:::||...|::.:::..||
Worm     6 ELITVQPEAFKALTPSKKFNETSNKLLDLAYSDDGNNLI-VSAEDVVLVYDLRDGSKGKSIECKK 69

  Fly    66 YGVDLIHFTHANNTAIHSSTKVDDTIRYLSLHDNKYLRYFPGHTKKVISLCISPVE-DTFLSGSL 129
            |||:.:.:..... .:||... |.|||.|.|....|:|||.||...|..:..:|.: :.|||.|:
Worm    70 YGVNCLEYLDTVK-CVHSGPN-DTTIRLLHLQKKSYVRYFDGHRMPVNFIRTNPKDREKFLSSSV 132

  Fly   130 DKTLRLWDLRSPNCQGLMHLSGRPIAAYDPEGLIFAAGVNSESIKLYDLRSFDKGPFVTFKLNQE 194
            |..:|::|.|:....|.:.....|:.|:||:|::||....|::|||:|:||||.|||.:|.:.:.
Worm   133 DGEIRMFDTRTFENYGCLLAGHTPLIAFDPDGILFAVATKSDTIKLFDMRSFDLGPFQSFIITKT 197

  Fly   195 KECDWTGLKFSRDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPNNKGIPIEASFSPDSQFIFSG 259
            ...:|:.::||..||.|||||....::.:|||.||.:.:|:.:.|...||:.||.|.||.|:..|
Worm   198 DNDEWSDIEFSPCGKFILISTTAGSVKWIDAFDGTLIHSFSQHKNPNKIPLRASVSTDSGFVMVG 262

  Fly   260 STDGRVHIWNADTGNKVSVLNGDHPGPVQCVQFNPKYMMLASACTNMAFWLPTSE 314
            |.|..|:|::.:||.....|...:|.|...|.||.|..::.|....:..|.|:.|
Worm   263 SADRNVYIYSTETGGVTCKLPTPYPEPSHVVAFNQKQFLMTSLGREVILWAPSEE 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr82	NP_609217.1	WD40	17..302	CDD:238121	101/285 (35%)
		WD40 repeat	26..63	CDD:293791	8/36 (22%)
		WD40 repeat	69..107	CDD:293791	12/37 (32%)
		WD40 repeat	112..150	CDD:293791	11/38 (29%)
		WD40 repeat	155..192	CDD:293791	19/36 (53%)
		WD40 repeat	199..235	CDD:293791	15/35 (43%)
		WD40 repeat	243..280	CDD:293791	15/36 (42%)
		WD40 repeat	287..309	CDD:293791	5/21 (24%)
swd-2.1	NP_501281.2	WD40	28..272	CDD:392136	89/246 (36%)
		WD40 repeat	33..67	CDD:293791	8/34 (24%)
		WD40 repeat	73..109	CDD:293791	12/37 (32%)
		WD40 repeat	114..152	CDD:293791	11/37 (30%)
		WD40 repeat	157..195	CDD:293791	19/37 (51%)
		WD40 repeat	202..238	CDD:293791	15/35 (43%)
		WD40 repeat	246..287	CDD:293791	16/40 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158675
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1446
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54522
OrthoDB	1	1.010	-	-		D1146727at2759
OrthoFinder	1	1.000	-	-		FOG0002456
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102214
Panther	1	1.100	-	-	O	PTHR19861
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1869
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.720