DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17292 and LPL

DIOPT Version :9

Sequence 1:	NP_001285749.1	Gene:	CG17292 / 34152	FlyBaseID:	FBgn0032029	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_000228.1	Gene:	LPL / 4023	HGNCID:	6677	Length:	475	Species:	Homo sapiens

Alignment Length:	254	Identity:	75/254 - (29%)
Similarity:	119/254 - (46%)	Gaps:	47/254 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 TAKFILYYGPTVADSDIYDLTDFQSLLEDEHLDLGKNTVLYLHGYLEDPDVES--IHVIAEAYLE 86
            ||:...:..|.||:|           :...|.:....|.:.:||:......||  ..::|..|..
Human    49 TAEDTCHLIPGVAES-----------VATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKR 102

  Fly    87 RKDTNLIVLDWGELADGNYMFDAFPNLKQLGPELAKVLLKM---FDHGLDIEKFHIVGHSMGGQL 148
            ..|:|:||:||...|..:|...| ...|.:|.::|:.:..|   |::.||  ..|::|:|:|...
Human   103 EPDSNVIVVDWLSRAQEHYPVSA-GYTKLVGQDVARFINWMEEEFNYPLD--NVHLLGYSLGAHA 164

  Fly   149 AGLLGREITKRTKGVRKIKRISALDPAFPLF---YPGTHLSANDAEFVDVIHTDAWLYGAP---- 206
            ||:.|....|      |:.||:.||||.|.|   ...:.||.:||:||||:||  :..|:|
Human   165 AGIAGSLTNK------KVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHT--FTRGSPGRSI 221

  Fly   207 ---TSTGTADFWPNGGYSLQPGCP-KRNYKMLSDNDLS--------SHRRSWWFWAESV 253
               ...|..|.:|||| :.||||. ....:::::..|.        ||.||...:.:|:
Human   222 GIQKPVGHVDIYPNGG-TFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSL 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17292	NP_001285749.1	Pancreat_lipase_like	23..303	CDD:238363	75/254 (30%)
LPL	NP_000228.1	Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:30559189	32..53		2/3 (67%)
		Lipase	33..473	CDD:332983	75/254 (30%)
		Essential for determining substrate specificity. /evidence=ECO:0000269\|PubMed:7592706	243..266		2/22 (9%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000269\|PubMed:27929370	417..421
		Important for heparin binding. /evidence=ECO:0000269\|PubMed:11342582	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:26725083, ECO:0000269\|PubMed:30559189	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010