DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG17292 and Lpl

DIOPT Version :9

Sequence 1:NP_001285749.1 Gene:CG17292 / 34152 FlyBaseID:FBgn0032029 Length:340 Species:Drosophila melanogaster
Sequence 2:NP_036730.1 Gene:Lpl / 24539 RGDID:3017 Length:474 Species:Rattus norvegicus


Alignment Length:257 Identity:79/257 - (30%)
Similarity:119/257 - (46%) Gaps:53/257 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 TAKFILYYGPTVADSDIYDLTDFQSLLEDEHLDLGKNTVLYLHGYLEDPDVES--IHVIAEAYLE 86
            ||:...:..|.:|||           :.:.|.:....|.:.:||:......||  ..::|..|..
  Rat    49 TAEDTCHLIPGLADS-----------VSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKR 102

  Fly    87 RKDTNLIVLDWGELADGNYMFDAFPNLKQLGPELAKV---LLKMFDHGLDIEKFHIVGHSMGGQL 148
            ..|:|:||:||...|..:|...| ...|.:|.::|:.   |.:.|::.||  ..|::|:|:|...
  Rat   103 EPDSNVIVVDWLYRAQQHYPVSA-GYTKLVGNDVARFINWLEEEFNYPLD--NVHLLGYSLGAHA 164

  Fly   149 AGLLGREITKRTKGVRKIKRISALDPAFPLF---YPGTHLSANDAEFVDVIHTDAWLYGAP---- 206
            ||:.|....|      |:.||:.||||.|.|   ...:.||.:||:||||:||  :..|:|    
  Rat   165 AGVAGSLTNK------KVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHT--FTRGSPGRSI 221

  Fly   207 ---TSTGTADFWPNGGYSLQPGCPKRNY---------KMLSDND---LSSHRRSWWFWAESV 253
               ...|..|.:|||| :.||||   |.         |.|.|.|   ..||.||...:.:|:
  Rat   222 GIQKPVGHVDIYPNGG-TFQPGC---NIGEAIRVIAEKGLGDVDQLVKCSHERSIHLFIDSL 279

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17292NP_001285749.1 Pancreat_lipase_like 23..303 CDD:238363 79/257 (31%)
LplNP_036730.1 Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 32..53 2/3 (67%)
lipo_lipase 33..472 CDD:132274 79/257 (31%)
Pancreat_lipase_like 37..334 CDD:238363 79/257 (31%)
Essential for determining substrate specificity. /evidence=ECO:0000250|UniProtKB:P06858 243..266 6/25 (24%)
PLAT_LPL 341..465 CDD:238856
Important for interaction with lipoprotein particles. /evidence=ECO:0000250|UniProtKB:P06858 417..421
Important for heparin binding. /evidence=ECO:0000250|UniProtKB:P06858 430..434
Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 443..467
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11610
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.010

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