DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and ABCC3

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_003777.2	Gene:	ABCC3 / 8714	HGNCID:	54	Length:	1527	Species:	Homo sapiens

Alignment Length:	1431	Identity:	478/1431 - (33%)
Similarity:	749/1431 - (52%)	Gaps:	202/1431 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLKTADLPENPREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWEL 67
            |.|..|....|.....|:|...||:.....|.|.:..|:.|||:...:|.:|:.:..:|..:|..
Human   198 SAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRK 262

  Fly    68 ELEKT--------------------------KGKPNLLRALLRVFGWYFALLGLVLFLLELGLRT 106
            :.::|                          ..||:.|:|||..||..| |:.....|::..|..
Human   263 QEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSF-LISACFKLIQDLLSF 326

  Fly   107 LQPIFLLKLIAYYTHGSESIESAYYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYR 171
            :.|..|..||.:.::........:..|..:.|||.:..:|:..|.......|:|.|.|:..:|||
Human   327 INPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYR 391

  Fly   172 KALRLSKSALGDTTAGHVVNLMSNDVGR-LDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFG 235
            |||.::.|....:|.|.:|||||.|..| :|||. |::.||..||:.:...|.:::.:|.:.:.|
Human   392 KALVITNSVKRASTVGEIVNLMSVDAQRFMDLAP-FLNLLWSAPLQIILAIYFLWQNLGPSVLAG 455

  Fly   236 VAFMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKK 300
            ||||:|.|||...:..:....:::.....|.|:::|:||::||:|:|:||||..|...|...|:.
Human   456 VAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQG 520

  Fly   301 EINAIRHVSYIR------GILLSFIIFLTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTT 359
            |:..:|..:|:.      .:...|::.|..:.:::    ||.....|..|.||:..:.:||||..
Human   521 ELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYV----YVDPNNVLDAEKAFVSVSLFNILRLP 581

  Fly   360 MTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAED 424
            :.: .||.||.:.:..||:||:|:::..:|.                           :....|.
Human   582 LNM-LPQLISNLTQASVSLKRIQQFLSQEEL---------------------------DPQSVER 618

  Fly   425 KLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSL 489
            |.:.|..|            |:|......|..:.|. :|:.::::|..|.::.:||..|.|||||
Human   619 KTISPGYA------------ITIHSGTFTWAQDLPP-TLHSLDIQVPKGALVAVVGPVGCGKSSL 670

  Fly   490 IQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFEL 554
            :.|:|||:....|::.:.||::|..|:.|:.:.|:::|:|||:.::.:||.:.::.|||..|.|:
Human   671 VSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEM 735

  Fly   555 LPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCM--RGYL 617
            ||..|:|.:||:|.:|||||:.|:|||||||.:..|:||||||||||:|||:|:|:..:  .|.|
Human   736 LPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVL 800

  Fly   618 RERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLDFASMLAD--PERD-------- 672
            ..:..:|.||.:.||...|.|:::..|:||.:|.|.:|.:....||:.|.:  |:.|
Human   801 AGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSW 865

  Fly   673 ---EQSEERSRSRSGSYTHSHSDQRRN-------SEQSLLSMADSCMD----------------- 710
               |.:|::..........:|:|...|       .:|.:..::....|
Human   866 TALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSE 930

  Fly   711 -----DLEAEQANNQERQEA-GQIGLRLYSKYFKAGGGFFAFFVMMGFCVL--SQGLASLGDYFL 767
                 :.:|:.|..||.:.| |.:.|.::..|.||.|    ....:..|:|  .|..|::|   .
Human   931 KVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVG----LCTTLAICLLYVGQSAAAIG---A 988

  Fly   768 SYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYI-FTVITVLTILVTVAR 831
            :.|                         ||.|..|  ...|:...:|.: ..|...|.||    :
Human   989 NVW-------------------------LSAWTND--AMADSRQNNTSLRLGVYAALGIL----Q 1022

  Fly   832 SFLFFNLAM-------KASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEIL-PAV 888
            .||....||       :|:..||.::.....|:...||:|.|||||||.||||:..|||:| |.:
Human  1023 GFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVI 1087

  Fly   889 MMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHL 953
            :|.:...|.|::.:|:::| ..|||.:..:.|.:::..::.||..|||.:||:|:::|||:|||.
Human  1088 LMLLNSFFNAISTLVVIMA-STPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHF 1151

  Fly   954 AASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDC------FCVIYIAII 1012
            :.::||.|.|||:...|..|...|...|.:..:.|.:|.::|    ||..      .||:..|.:
Human  1152 SETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNR----WLSIGVEFVGNCVVLFAAL 1212

  Fly  1013 TLSFFIF--PPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEA 1075
               |.:.  ...|.|.|||:::.::.:|..:.|.:|..::||:.:.|||||.||...|    .||
Human  1213 ---FAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTE----TEA 1270

  Fly  1076 P---ADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLI 1137
            |   ...:||:.||.:|::.|...|:||.|.  .:.||:.||..:...|||||||||||||||:.
Human  1271 PWVVEGSRPPEGWPPRGEVEFRNYSVRYRPG--LDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMT 1333

  Fly  1138 NALFR-LSYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRS 1201
            ..||| |....|.:.||..:.:::|||||||:::||||:|:|||||:|.|||||..||::.:|.:
Human  1334 LCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWA 1398

  Fly  1202 LEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGL 1266
            ||...|...|:..|:||..:.:|||.|.|||||||||||||:||::||||:|||||.:|.:||.|
Human  1399 LELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNL 1463

  Fly  1267 IQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTGH 1331
            ||.|||.:|..||||||||||:||||..:|||:|.|...||.:|..|  :|...:|:||.:..|.
Human  1464 IQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANL--IAARGIFYGMARDAGL 1526

  Fly  1332 A 1332
            |
Human  1527 A 1527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	469/1403 (33%)
		ABC_membrane	107..360	CDD:294371	80/259 (31%)
		ABCC_MRP_domain1	445..645	CDD:213217	82/201 (41%)
		ABC_membrane	815..1014	CDD:294371	72/213 (34%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	124/221 (56%)
ABCC3	NP_003777.2	SunT	7..1526	CDD:331423	476/1428 (33%)
ABCC3	NP_003777.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..932		1/21 (5%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151508
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.660