DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7627 and YKR104W

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_013030.1	Gene:	YKR104W / 853979	SGDID:	S000001812	Length:	306	Species:	Saccharomyces cerevisiae

Alignment Length:	317	Identity:	135/317 - (42%)
Similarity:	201/317 - (63%)	Gaps:	33/317 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1055 MTAVERVVEYEDI--EPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVI 1117
            |::|||:.||.||  |..|.:      .||.:||:.|.:....|||||:  |.|...|.::||.:
Yeast     1 MSSVERIKEYTDIPSESNGYI------SPPANWPQTGDVELKNLSLRYS--PHSSKALDNVSFKV 57

  Fly  1118 KPKEKVGIVGRTGAGKSSLINALFRLS-YNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSG 1181
            |...||||||||||||||:|.|::||| :.:|::.||.:|...:.|..||:.||.|||:|.||.|
Yeast    58 KAGTKVGIVGRTGAGKSSIIAAIYRLSDWENGTITIDNKDIKHIPLERLRNSISCIPQDPTLFDG 122

  Fly  1182 TMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADL--------PS-----------GLQSKITEGGT 1227
            |:|.||||||.|||.:::..|.:|.|.|...:|        |:           .|.:.:..||:
Yeast   123 TVRSNLDPFDRYSDVQIYGVLSKVGLIEECDELCLIFEQEQPNFSSHKLRNRFIDLNTVVKSGGS 187

  Fly  1228 NFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMD 1292
            |.|.|||||:||||::|....|:::|||||::|..:|..||.|||...|..|:|||||||.:::|
Yeast   188 NLSQGQRQLLCLARSMLGARNIMLIDEATASIDYISDAKIQKTIRETMKNTTILTIAHRLRSVID 252

  Fly  1293 SDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTGHATYESLLKIAQKAFENRQ 1349
            .||:|||:.||..|:..||.|::..:: :|:.:.:|:|.  :|:|.::|:.:|:|::
Yeast   253 YDKILVMEMGRVKEYDHPYTLISDRNT-IFYRLCRQSGE--FENLFELAKVSFDNKR 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	127/281 (45%)
		ABC_membrane	107..360	CDD:294371
		ABCC_MRP_domain1	445..645	CDD:213217
		ABC_membrane	815..1014	CDD:294371
		ABCC_MRP_domain2	1089..1310	CDD:213211	110/240 (46%)
YKR104W	NP_013030.1	ABCC_NFT1	27..270	CDD:213269	112/244 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344643
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740