DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and NFT1

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_013029.3	Gene:	NFT1 / 853978	SGDID:	S000001811	Length:	1218	Species:	Saccharomyces cerevisiae

Alignment Length:	1015	Identity:	269/1015 - (26%)
Similarity:	453/1015 - (44%)	Gaps:	188/1015 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 KGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTKGKPNLLRALLRVFGWYFALLGLVLF 98
            |..|..|...|::.....:||..    :.|::|:..:|.:..||::.....||     :..|.|.
Yeast   263 KAYKHCLGNADIWDLDINNKSIA----ILANFEMSSKKGRLLPNIICYFKAVF-----ISQLFLA 318

  Fly    99 LLELGLRTLQPIFLLKLIAYYTH-GSESIESAYYYAAGVIL-------CSALNVIIMHPYMLGTM 155
            .:...|..:..:.:.::::|... .|:|......|.:.:::       |....:.:...   |||
Yeast   319 FVSSFLNFVPSLLMPRILSYVNDPKSKSWNLVSLYVSSMLVSKIIATTCRGQGLFLGEK---GTM 380

  Fly   156 HVGLKMRVGMCSMIYRKALRLSKSALGDTTA-----------------------------GHVVN 191
                ::|..:.|.||.|.||  ::.|.|:|.                             ..|.|
Yeast   381 ----QLRTVLISNIYSKTLR--RTILKDSTTSLQKNASTSFEENPDSSEAEPRKKSSRKDNSVNN 439

  Fly   192 LMSNDVGRLDLATIFVHYLWVGPLETLFIT----YLMYREIGIAAVFGVAFMLLFIPLQAYLGKR 252
            :||.|..::..| :...||   ..|.:|:|    .::|..:|.:|..|...:|..|||..:....
Yeast   440 VMSIDAFKVSEA-MNTFYL---ACEAVFMTVTALMILYSLLGWSAFAGTFALLAMIPLNFWCATF 500

  Fly   253 TSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIR---------HV 308
            ....:....:.||:|...::|.::.|:|||:.|||..|...:...|..||..::         |:
Yeast   501 YGNYQADQLILTDKRTSGISEALNSIRVIKLLAWENLFYQKIINVRDGEIRLLKKKATIFFLNHL 565

  Fly   309 SYIRG-ILLSFIIFLTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMA 372
            .:..| .|:|.|.|    |:|:......     |||.:||...:.:.||||.|.. ....:|.:.
Yeast   566 IWFFGPTLVSAITF----SVFIKFQNQT-----LTPTIAFTALSLFAILRTPMDQ-IASTVSLLI 620

  Fly   373 ETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNEN 437
            ::.:|::|:|.|:...||...::       .:.||.:....|...|.:.||...
Yeast   621 QSFISLERIQDYLNESETRKYEI-------LEQSNTKFGFEDASMEWEAAETSF----------- 667

  Fly   438 AKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESG 502
             ||....|              |:.||.:|         .|:|.||||||||:..:||||...||
Yeast   668 -KLKNISI--------------DFKLNSLN---------AIIGPTGSGKSSLLLGLLGELNLLSG 708

  Fly   503 EIKV----------------NGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERD 551
            :|.|                ..||:|.||.|||.|||::.|::||:..:::::..|:|.|.|::|
Yeast   709 KIYVPTVESRDDLEIGKDGMTNSMAYCSQTPWLISGTIKDNVVFGEIFNKQKFDDVMKSCCLDKD 773

  Fly   552 FELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRG- 615
            .:.:....:|.||:.|.||||||:.||:||||:|..:...:|||.|||||...|.:::|:|:.|
Yeast   774 IKAMTAGIRTDVGDGGFSLSGGQQQRIALARAIYSSSRYLILDDCLSAVDPETALYIYEECLCGP 838

  Fly   616 YLRERIVILATHQLQFL-QHADQIVIMDKGRVSAVGTYESLRESGLDFASMLADPERDEQSEERS 679
            .::.|..|:.:|.:..: :.||.:||:|:|.|.:.|....|.:|             :|...|..
Yeast   839 MMKGRTCIITSHNISLVTKRADWLVILDRGEVKSQGKPSDLIKS-------------NEFLRESI 890

  Fly   680 RSRSGSYTHSHSDQRRNSEQSLLSMAD----SCMDDLEAEQANNQERQEAGQIGLRLY---SKYF 737
            .:.|.:.||:..|.:|::........|    :..|::.||..|.:|.:..|.:....|   :.||
Yeast   891 NNDSKNTTHNQIDLKRSTTSKKTKNGDPEGGNSQDEVCAEVENFEETKMEGSVKFSAYKWLADYF 955

  Fly   738 KAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRD 802
               ||....||.....:|..|:.....::|.||:             ||..|..    .||||..
Yeast   956 ---GGLGVVFVFTSSSILIHGITLSQGFWLRYWL-------------DTGSSGS----KSTWLYR 1000

  Fly   803 I--GLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTN 865
            |  |.| :...|.|||  :|.:::..:|..:.::........:.::...:...|..|.:.|.|..
Yeast  1001 IVEGHS-NIYFLLTYI--IIGLVSSFLTSGKVWIAIISGTNVTKKIFAKLLSSILYAKLRFHNVT 1062

  Fly   866 PSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTF 930
            |:|||:|||||||..:|:.|......:....:....|:::|..|.|.||:..:.|..::|.:.|.
Yeast  1063 PTGRIMNRFSKDMDIIDQQLIPNFEGLSYSVVVCLWIILLIGYVTPQFLLFAIPLCALYYTVCTL 1127

  Fly   931 YLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQR 970
            ||:.||::||::.|..||::...|.::.|::||||...:|
Yeast  1128 YLRASRELKRIDNINISPIHQLFAEAIKGVTTIRALADER 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	269/1015 (27%)
		ABC_membrane	107..360	CDD:294371	69/303 (23%)
		ABCC_MRP_domain1	445..645	CDD:213217	79/217 (36%)
		ABC_membrane	815..1014	CDD:294371	46/156 (29%)
		ABCC_MRP_domain2	1089..1310	CDD:213211
NFT1	NP_013029.3	MRP_assoc_pro	252..>1218	CDD:188098	269/1015 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344641
Domainoid	1	1.000	64	1.000	Domainoid score	I2425
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830