DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7627 and ABCC11

DIOPT Version :9

Sequence 1:NP_001245943.1 Gene:CG7627 / 34148 FlyBaseID:FBgn0032026 Length:1355 Species:Drosophila melanogaster
Sequence 2:NP_001357425.1 Gene:ABCC11 / 85320 HGNCID:14639 Length:1384 Species:Homo sapiens


Alignment Length:1389 Identity:439/1389 - (31%)
Similarity:708/1389 - (50%) Gaps:178/1389 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 WYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTKG--KPNLLRALLR---- 84
            |.| |..|:..:..||...:........|:....:|...||.|:.: :|  |.::|..:||    
Human    99 WLT-PLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSR-RGIEKASVLLVMLRFQRT 161

  Fly    85 --VFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYT--------HG---------SESIESAY 130
              :|.   ||||:...:..:    |.||.::..|..|:        ||         ||.::|..
Human   162 RLIFD---ALLGICFCIASV----LGPILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLS 219

  Fly   131 YYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSN 195
            :.::.:|                .....::.|..:.|..:.|.::. ||.: ..|:|..::..:.
Human   220 FSSSWII----------------NQRTAIRFRAAVSSFAFEKLIQF-KSVI-HITSGEAISFFTG 266

  Fly   196 DVGRLDLATIFVHYLW----VGPLETLFITYLM------YREIGIAAVFGVAFMLLFIPLQAYLG 250
            |          |:||:    .|||..:....|:      |..||..|...:...||..||..::.
Human   267 D----------VNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMT 321

  Fly   251 KRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGIL 315
            :.....:..|:..:|:|:|:.:|:::.|::||||.||.||..::...|:||...:.....::.  
Human   322 RMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQS-- 384

  Fly   316 LSFIIFLTRVSIFL----SLVGYVLLGTF----LTPEVAFLITAYYNILRTTMTVFF-PQGISQM 371
                  ||.:::|:    :...:||:.|.    ||..:||.:.|..|:||  ::||| |..:..:
Human   385 ------LTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLR--LSVFFVPIAVKGL 441

  Fly   372 AETLVSIKRVQKYMQSDE-----TNVMDMSVDLT-EDFQGSNQETVHADGDEERDEAEDKLLGPP 430
            ..:..::.|.:|:...:.     ..:.|.|..|. |:...|.|:|.                 |.
Human   442 TNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTC-----------------PG 489

  Fly   431 IATVNENAKLSEAGISISGLMAKWDVNSPDY-------SLNGVNLRVQPGTMLGIVGRTGSGKSS 488
            |  ||...:|...|.:..|:....|...|:.       .|:.:||.|..|.|||:.|.|||||||
Human   490 I--VNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSS 552

  Fly   489 LIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFE 553
            |:.|||.|:....|.:.|.||::|..|:.|:.||.:|:|||.|...|:.||.:|:..|:|.||.|
Human   553 LLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617

  Fly   554 LLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLR 618
            ||||.|.|.:||||.:||||||.|||||||||.:..||||||||||||.||.:|:||:|::..||
Human   618 LLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLR 682

  Fly   619 ERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLDFASMLADPERDEQSEERSRSRS 683
            .:.|:|.|||||:|:...||::::.|::...||:..|.:....:|.::....::..|:....   
Human   683 GKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQD--- 744

  Fly   684 GSYTHSHSDQRRNSEQSLLSMADSCMD----DLEAEQANNQERQEAGQIGLRLYSKYFKAGGGFF 744
               |...:::.:...|:|.:..:..::    ::...|...:|..|.|.:..|:|..|.:|.||:.
Human   745 ---TAKIAEKPKVESQALATSLEESLNGNAGNVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYM 806

  Fly   745 AFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDA 809
            ...::..|.||...|.....::||||:.:........::|.|             :.|:|...|.
Human   807 VSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGT-------------MADLGNIADN 858

  Fly   810 EMLDTY--IFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILN 872
            ..|..|  ::.:..:|.|.|.|..|.:|..:..|||..|||.:|..:.|..|.||:|.|.||:||
Human   859 PQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLN 923

  Fly   873 RFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRD 937
            .|:.|:.|:|::||......:.:.|.:..::::::|::|..|:...::.:|.:.....:.|....
Human   924 CFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGV 988

  Fly   938 VKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLD 1002
            .||:|..:|||::||:..||.|||:|..:|......::|....|..::...:|:|::|    |:.
Human   989 FKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTR----WMA 1049

  Fly  1003 CFCVIYIAIITLSFFIFPPANGGDVG-----LAITQAMGMTGMVQWGMRQSAELENTMTAVERVV 1062
            ....|...::||:..:|.........     :|:...:.:....|...|...|.|...|||||::
Human  1050 LRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERIL 1114

  Fly  1063 EYEDIEPEGALEAPADKKP---PKSWPEQGKIVFDELSLRY---TPDPKSENVLKSLSFVIKPKE 1121
            :|..:   ...|||...:.   |:.||:.|:|:|.:..::|   ||     .||..::..|:..|
Human  1115 QYMKM---CVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTP-----TVLHGINLTIRGHE 1171

  Fly  1122 KVGIVGRTGAGKSSLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRY 1185
            .||||||||:|||||..||||| ....|.:|||..|...:||.|||||:|:|||:|||.|||:|:
Human  1172 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRF 1236

  Fly  1186 NLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRIL 1250
            ||||||.::|.::|.:||...|.:.::..|..|.:.:.|.|.|||||:|||:|:|||:||.::|:
Human  1237 NLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKII 1301

  Fly  1251 VMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLT 1315
            ::|||||::|.:||.|||.|||..|:.||||.||||:.|:::.|.:|||..|:.|||..| |:|.
Human  1302 LIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRP-EVLR 1365

  Fly  1316 LADSKVFHGMVKQTGHATYESLLK 1339
            .....:|..::     ||..|.|:
Human  1366 KKPGSLFAALM-----ATATSSLR 1384

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7627NP_001245943.1 CFTR_protein 12..1315 CDD:273530 433/1363 (32%)
ABC_membrane 107..360 CDD:294371 65/287 (23%)
ABCC_MRP_domain1 445..645 CDD:213217 102/206 (50%)
ABC_membrane 815..1014 CDD:294371 58/200 (29%)
ABCC_MRP_domain2 1089..1310 CDD:213211 113/224 (50%)
ABCC11NP_001357425.1 PLN03130 85..1373 CDD:215595 434/1371 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 504..523 3/18 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151559
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S1888
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.600

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