DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and YOR1

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_011797.3	Gene:	YOR1 / 853198	SGDID:	S000003513	Length:	1477	Species:	Saccharomyces cerevisiae

Alignment Length:	1473	Identity:	445/1473 - (30%)
Similarity:	717/1473 - (48%)	Gaps:	211/1473 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSLKTADLPEN-------PREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLG 58
            :.|.|..::|:.       |..|.|.||...||:.:|....|.|||:...||::.......|||.
Yeast    90 LHSKKIPEVPQTDDERKIYPLFHTNIISNMFFWWVLPILRVGYKRTIQPNDLFKMDPRMSIETLY 154

  Fly    59 NKLCASWELELEKTK---------------------GKPNLLRALLRVF-GWYFALLGLVLFLLE 101
            :....:.....|||:                     .|..:|||||..| ..||  :.:|..:|.
Yeast   155 DDFEKNMIYYFEKTRKKYRKRHPEATEEEVMENAKLPKHTVLRALLFTFKKQYF--MSIVFAILA 217

  Fly   102 LGLRTLQPIFLLKLIAYYTH----GSESIESAYYYAAGVILCSALNVIIMHPYMLGTMHVGLKMR 162
            .......|:...:||.:...    .|..:.....||.|..|...:|.:..:.:...:...|::.:
Yeast   218 NCTSGFNPMITKRLIEFVEEKAIFHSMHVNKGIGYAIGACLMMFVNGLTFNHFFHTSQLTGVQAK 282

  Fly   163 VGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYRE 227
            ..:.....:|....|..|......|.|.:.::.|:.|::.|..|..:|...|........|:...
Yeast   283 SILTKAAMKKMFNASNYARHCFPNGKVTSFVTTDLARIEFALSFQPFLAGFPAILAICIVLLIVN 347

  Fly   228 IGIAAVFGVAFML--LFIPLQAY---LGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWE 287
            :|..|:.|:....  .||.|.|:   ||     .|:...:.||.||.||.|:::.|::||.|.||
Yeast   348 LGPIALVGIGIFFGGFFISLFAFKLILG-----FRIAANIFTDARVTMMREVLNNIKMIKYYTWE 407

  Fly   288 LPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFLTRVSIFLSLVGYVLLGTFLT---------- 342
            ..:|..:...|.|||:.:|.:...|..|::..:.|..::   |||      |||.
Yeast   408 DAYEKNIQDIRTKEISKVRKMQLSRNFLIAMAMSLPSIA---SLV------TFLAMYKVNKGGRQ 463

  Fly   343 PEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQS--DETNVM-----------D 394
            |...|...:.:.:|...| .|.|..|....:.::.:.|:|..:::  |:.|.|           .
Yeast   464 PGNIFASLSLFQVLSLQM-FFLPIAIGTGIDMIIGLGRLQSLLEAPEDDPNQMIEMKPSPGFDPK 527

  Fly   395 MSVDLT------EDFQGSNQETVHADGDEERDEAEDK------LLGPPIATVNENAKLSEAGISI 447
            :::.:|      ||:: .|.....|.| |.:||.:..      ..|.|.|:.|:..:|..
Yeast   528 LALKMTHCSFEWEDYE-LNDAIEEAKG-EAKDEGKKNKKKRKDTWGKPSASTNKAKRLDN----- 585

  Fly   448 SGLMAKWDVNSPD----YSLNG---VNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIK 505
               |.| |.:.|:    .|..|   :|..::.|..:.|.|..|:|||||:.|:.|.:....|:::
Yeast   586 ---MLK-DRDGPEDLEKTSFRGFKDLNFDIKKGEFIMITGPIGTGKSSLLNAMAGSMRKTDGKVE 646

  Fly   506 VNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASL 570
            |||.:..... ||:.:.:||.||:||.|.::.:|.:||:.|:|:.|.::||..|.|.:||||.:|
Yeast   647 VNGDLLMCGY-PWIQNASVRDNIIFGSPFNKEKYDEVVRVCSLKADLDILPAGDMTEIGERGITL 710

  Fly   571 SGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHA 635
            ||||||||:|||:||::..|||.||.|||||:.|.:|:.::|:.|.|..:..|||||||..::.|
Yeast   711 SGGQKARINLARSVYKKKDIYLFDDVLSAVDSRVGKHIMDECLTGMLANKTRILATHQLSLIERA 775

  Fly   636 DQIVIMDKGRVSAVGTYESLRESG------LDFASMLADPERDEQ----SEERSRSRSGSYTHSH 690
            .:::::.......:||.:.|:...      |.|:|..::.|.:||    :.|..:.:..|.....
Yeast   776 SRVIVLGTDGQVDIGTVDELKARNQTLINLLQFSSQNSEKEDEEQEAVVAGELGQLKYESEVKEL 840

  Fly   691 SD-QRRNSEQSLLSMADSCMDDLEAEQANNQERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCV 754
            :: :::.:|.|..:.:...:.|   ...:::|.:....|.|::|.:|.||..|.:.|..:..:.:
Yeast   841 TELKKKATEMSQTANSGKIVAD---GHTSSKEERAVNSISLKIYREYIKAAVGKWGFIALPLYAI 902

  Fly   755 LSQG--LASL-GDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYI 816
            |..|  ..|| ...:||||...|                 .:.|..::.  :||         |.
Yeast   903 LVVGTTFCSLFSSVWLSYWTENK-----------------FKNRPPSFY--MGL---------YS 939

  Fly   817 FTVITVLTILVTVARSFLFFN--------LAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNR 873
            |.|..          :|:|.|        :.:.||..|:....:.|....|.:.:|.|.||||||
Yeast   940 FFVFA----------AFIFMNGQFTILCAMGIMASKWLNLRAVKRILHTPMSYIDTTPLGRILNR 994

  Fly   874 FSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDV 938
            |:||...:|..|...:..:...|..:.|:.::..|..|.|.|....|.:||..:...|..:.|::
Yeast   995 FTKDTDSLDNELTESLRLMTSQFANIVGVCVMCIVYLPWFAIAIPFLLVIFVLIADHYQSSGREI 1059

  Fly   939 KRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDC 1003
            ||:||:.||.||::|...|.|:.||:|:.:|....|:.|...:..:.|.|:.:...|..|.:||.
Yeast  1060 KRLEAVQRSFVYNNLNEVLGGMDTIKAYRSQERFLAKSDFLINKMNEAGYLVVVLQRWVGIFLDM 1124

  Fly  1004 FCVIYIAIITL-----SFFIFPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVE 1063
            ..:.:..||||     :|    |.:...||:.:|..:.:.|::...:|...:.||.|.:.||:|.
Yeast  1125 VAIAFALIITLLCVTRAF----PISAASVGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVT 1185

  Fly  1064 YEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGR 1128
            |....|..|.....:..||:|||..|:|:|:.:...|.|.  ...|||:|:..||..||:||.||
Yeast  1186 YATELPLEASYRKPEMTPPESWPSMGEIIFENVDFAYRPG--LPIVLKNLNLNIKSGEKIGICGR 1248

  Fly  1129 TGAGKSSLINALFRLS-YNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDE 1192
            ||||||::::||:||: ...|.:|||..|.|::||.|||.|::||||:||||.||:|.|||||:|
Yeast  1249 TGAGKSTIMSALYRLNELTAGKILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPFNE 1313

  Fly  1193 YSDDKLWRS-----------LEEVKLKEVVADLPSG------LQSKITEGGTNFSVGQRQLVCLA 1240
            .:||:||.:           |.||||::...:...|      |...:.|.|:|||:|:|||:.|.
Yeast  1314 RTDDELWDALVRGGAIAKDDLPEVKLQKPDENGTHGKMHKFHLDQAVEEEGSNFSLGERQLLALT 1378

  Fly  1241 RAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAV 1305
            ||::|:::||::||||::||.:|||.|||.|..:|.:||:|.|||||.||::.|::||::.|...
Yeast  1379 RALVRQSKILILDEATSSVDYETDGKIQTRIVEEFGDCTILCIAHRLKTIVNYDRILVLEKGEVA 1443

  Fly  1306 EFGTPYELLTLADSKVFHGMVKQTGHATYESLLKIAQKAFENR 1348
            ||.||:.|.:..|| :|..|..::|         |.:..||||
Yeast  1444 EFDTPWTLFSQEDS-IFRSMCSRSG---------IVENDFENR 1476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	432/1427 (30%)
		ABC_membrane	107..360	CDD:294371	63/271 (23%)
		ABCC_MRP_domain1	445..645	CDD:213217	82/206 (40%)
		ABC_membrane	815..1014	CDD:294371	60/206 (29%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	112/238 (47%)
YOR1	NP_011797.3	MRP_assoc_pro	92..1468	CDD:188098	440/1461 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710