Protein Alignment CG7627 and YCF1

DIOPT Version :9

• Sequence 1: NP_001245943.1
• Gene: CG7627 / 34148
• FlyBaseID: FBgn0032026
• Length: 1355
• Species: Drosophila melanogaster
• Sequence 2: NP_010419.3
• Gene: YCF1 / 851713
• SGDID: S000002542
• Length: 1515
• Species: Saccharomyces cerevisiae
• Alignment Length: 1418
• Identity: 470/1418 - (33%)
• Similarity: 733/1418 - (51%)
• Gaps: 216/1418 - (15%)

  Fly    12 NPREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTKGKP 76
            ||.:..|..|...|.:.......|.::.|...|||:..:...||.|..||..:||.|| |.|..|
Yeast   210 NPYDSANIFSRITFSWMSGLMKTGYEKYLVEADLYKLPRNFSSEELSQKLEKNWENEL-KQKSNP 273

  Fly    77 NLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYT-HGSE---------------- 124
            :|..|:.|.||....|......:.:: |...||..|..||.:.| :.||
Yeast   274 SLSWAICRTFGSKMLLAAFFKAIHDV-LAFTQPQLLRILIKFVTDYNSERQDDHSSLQGFENNHP 337

  Fly   125 ---SIESAYYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTA 186
               .|...:..|..:.|.......::|.|.|...:.|:.::..:.::||:|:|.||..|.|.::.
Yeast   338 QKLPIVRGFLIAFAMFLVGFTQTSVLHQYFLNVFNTGMYIKSALTALIYQKSLVLSNEASGLSST 402

  Fly   187 GHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGK 251
            |.:|||||.||.:|...|.:::.:|.||.:.:...|.:|:.:|.:...||..:::.:||.::|.:
Yeast   403 GDIVNLMSVDVQKLQDLTQWLNLIWSGPFQIIICLYSLYKLLGNSMWVGVIILVIMMPLNSFLMR 467

  Fly   252 RTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILL 316
            ....|:.......|||.|:::||::.|:.:|:||||.|:        ::::..:|:...::.
Yeast   468 IQKKLQKSQMKYKDERTRVISEILNNIKSLKLYAWEKPY--------REKLEEVRNNKELKN--- 521

  Fly   317 SFIIFLTRVSIFLSLVGY--------VLLGTF----------LTPEVAFLITAYYNILRTTMTVF 363
                 ||::..::::..:        |...||          ||.::.|.....:|:|...:.:
Yeast   522 -----LTKLGCYMAVTSFQFNIVPFLVSCCTFAVFVYTEDRALTTDLVFPALTLFNLLSFPLMI- 580

  Fly   364 FPQGISQMAETLVSIKRVQKYMQSDE------------TNVMDMSVDLTEDFQGSNQETVHADGD 416
            .|..::...|..|||.|:..:..::|            .|:.|:::::.:|
Yeast   581 IPMVLNSFIEASVSIGRLFTFFTNEELQPDSVQRLPKVKNIGDVAINIGDD-------------- 631

  Fly   417 EERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDY--SLNGVNLRVQPGTMLGIV 479
                           ||.                  .|. ..|:|  :|..:|.:.:.|.:..||
Yeast   632 ---------------ATF------------------LWQ-RKPEYKVALKNINFQAKKGNLTCIV 662

  Fly   480 GRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVK 544
            |:.||||::|:..:||:|....|...|:||::|.||.||:.:|||::|||||...|...|.|.:|
Yeast   663 GKVGSGKTALLSCMLGDLFRVKGFATVHGSVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTIK 727

  Fly   545 KCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLF 609
            .|||..|..:|...|||:|||:|.|||||||||:|||||||.....|||||||:|||.||||||.
Yeast   728 ACALTIDLAILMDGDKTLVGEKGISLSGGQKARLSLARAVYARADTYLLDDPLAAVDEHVARHLI 792

  Fly   610 EQCM--RGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESL----------------- 655
            |..:  .|.|..:..:|||:::..|..||.|.::|.|.::..|||:.:
Yeast   793 EHVLGPNGLLHTKTKVLATNKVSALSIADSIALLDNGEITQQGTYDEITKDADSPLWKLLNNYGK 857

  Fly   656 ------RESGLDFASMLADPERDEQSEERSRSRSGSYTHSHSDQ---RRNSEQSLLSMADSCMDD 711
                  .|.|....|.:.:.....:.|.....:.......:||.   ||.|:.:|.|     :|.
Yeast   858 KNNGKSNEFGDSSESSVRESSIPVEGELEQLQKLNDLDFGNSDAISLRRASDATLGS-----IDF 917

  Fly   712 LEAEQANNQERQEAGQIGLRLYSKYFKA-GGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKG 775
            .:.|....:|.:|.|::...:|.:|.|| .......|::  |.|:|..|:.:|:.:|.:|    .
Yeast   918 GDDENIAKREHREQGKVKWNIYLEYAKACNPKSVCVFIL--FIVISMFLSVMGNVWLKHW----S 976

  Fly   776 NVAYRADNNDTTRSEELEPRLSTWLR---DIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFN 837
            .|..|..:|         |..:.:|.   .:|:   ...|.|.|.|:  ||.:..|:
Yeast   977 EVNSRYGSN---------PNAARYLAIYFALGI---GSALATLIQTI--VLWVFCTI-------- 1019

  Fly   838 LAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGI 902
               .||..|||.|...:.||.|.||.|.|.||||||||.|:.:||.:|.....   |.|:....:
Yeast  1020 ---HASKYLHNLMTNSVLRAPMTFFETTPIGRILNRFSNDIYKVDALLGRTFS---QFFVNAVKV 1078

  Fly   903 VIVIAVV-----NPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLST 962
            ...|.|:     ..:|:|..:.:..|:||  .:||:|||:::|:::|||||:|||...:|.||:|
Yeast  1079 TFTITVICATTWQFIFIIIPLSVFYIYYQ--QYYLRTSRELRRLDSITRSPIYSHFQETLGGLAT 1141

  Fly   963 IRAFGAQR----VLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCF-CVIYIAIITLSFFIFPPA 1022
            :|.:..|:    :.:...||    :.||||..|:.:|...|.|:.. .:|.:...|||.|.....
Yeast  1142 VRGYSQQKRFSHINQCRIDN----NMSAFYPSINANRWLAYRLELIGSIIILGAATLSVFRLKQG 1202

  Fly  1023 --NGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSW 1085
              ..|.|||:::.|:.:|..:.|.:|.:.|:|..:.:|||:.||.|::.|..|.... .:|||.|
Yeast  1203 TLTAGMVGLSLSYALQITQTLNWIVRMTVEVETNIVSVERIKEYADLKSEAPLIVEG-HRPPKEW 1266

  Fly  1086 PEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGS 1149
            |.||.|.|:..|.||.|:  .:.|||.::..|||.||||||||||||||||..|||| :..::|:
Yeast  1267 PSQGDIKFNNYSTRYRPE--LDLVLKHINIHIKPNEKVGIVGRTGAGKSSLTLALFRMIEASEGN 1329

  Fly  1150 VLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADL 1214
            ::||....:|:||:|||.|:|||||:..:|.||:|.|:||.::|:|:.:||:||...|||.|..:
Yeast  1330 IVIDNIAINEIGLYDLRHKLSIIPQDSQVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSM 1394

  Fly  1215 PS-GLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKEC 1278
            .: ||.:::||||.|.|||||||:|||||:|..::|||:|||||.||.:||.::|.|||..||:.
Yeast  1395 SNDGLDAQLTEGGGNLSVGQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAFKDR 1459

  Fly  1279 TVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSK-VFHGMVKQTG 1330
            |:|||||||:||||||:::|:|.|:..||.:|.:|  |:|:| :|:.:..:.|
Yeast  1460 TILTIAHRLNTIMDSDRIIVLDNGKVAEFDSPGQL--LSDNKSLFYSLCMEAG 1510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	465/1400 (33%)
		ABC_membrane	107..360	CDD:294371	69/290 (24%)
		ABCC_MRP_domain1	445..645	CDD:213217	93/203 (46%)
		ABC_membrane	815..1014	CDD:294371	70/208 (34%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	122/222 (55%)
YCF1	NP_010419.3	MRP_assoc_pro	27..1511	CDD:188098	470/1418 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720