DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and YBT1

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_013052.1	Gene:	YBT1 / 850678	SGDID:	S000003971	Length:	1661	Species:	Saccharomyces cerevisiae

Alignment Length:	1493	Identity:	457/1493 - (30%)
Similarity:	724/1493 - (48%)	Gaps:	267/1493 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PENPREHCNFISAACFWYTMPTFI-KGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTK 73
            ||.......||   | |..:.:|: |..|.::..||::..:.:..|..:..|.....:   .|.|
Yeast   280 PEPVTSIAGFI---C-WAWLDSFVWKAHKVSIKVKDIWGLMMQDYSFFVVKKFRYFVD---HKVK 337

  Fly    74 GKPNLLRALLRVFGWY------FALLGLVLFLLELGLRTLQPIFLLKLIAYYTHGSESIES--AY 130
            .|......|...|..|      :|.||.||..:        |..|||.|..|.....|..|  |:
Yeast   338 RKRIFSLNLFFFFSNYLVLQCFWAFLGSVLSFI--------PTVLLKRILEYVEDQSSAPSNLAW 394

  Fly   131 YYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRL------------------- 176
            :|...:.:...|..|.....:.....|.::|:..:.|.||.||||.
Yeast   395 FYVTVMFVGRILVAICQAQALFFGRRVCIRMKSIIISEIYTKALRRKISTNKTKPSNEDPQEIND 459

  Fly   177 SKSALGD------TTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFG 235
            .||..||      ...|.::|||:.|..::.....::|......:.|:....|:||.:|.||:.|
Yeast   460 QKSINGDEESTSSANLGAIINLMAIDAFKVSEICGYLHSFLEAFVMTVVALALLYRLLGFAAIVG 524

  Fly   236 VAFMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKK 300
            |..::..:||...|.|....|:.:....||.|::.:||....|::||.::||..||        |
Yeast   525 VLIIVAMLPLNYKLAKYIGDLQKKNLAVTDNRIQKLNEAFQAIRIIKYFSWEENFE--------K 581

  Fly   301 EINAIRH----VSYIRGI---LLSFIIFLTRVSIFLSLVGYVLL--GTFLTPEVAFLITAYYNIL 356
            :||.||.    :..:|.|   :.||:.|:|...:..:...|.:.  |..||..|||...:.:.:|
Yeast   582 DINTIRENELSLLLMRSIVWSISSFLWFVTPTIVTAASFAYYIYVQGEVLTTPVAFTALSLFTLL 646

  Fly   357 RTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDE 421
            |..:...... :|.:.::.||:.|||.::..::|...|             |.|:..:|:.
Yeast   647 RDPLDRLSDM-LSFVVQSKVSLDRVQDFLNENDTKKYD-------------QLTIDPNGNR---- 693

  Fly   422 AEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGK 486
                       ...||:.:|            ||.::.|:.|..:|:..:.|.:..::|.|||||
Yeast   694 -----------FAFENSTIS------------WDKDNQDFKLKDLNIEFKTGKLNVVIGPTGSGK 735

  Fly   487 SSLIQAILGELPAESGEIKV-------------NG---SMSYASQEPWLFSGTVRQNILFGQPMD 535
            :||:.|:|||:...:|::.|             ||   |::|.||..||.:.||:.||||..|.:
Yeast   736 TSLLMALLGEMYLLNGKVVVPALEPRQELIVDANGTTNSIAYCSQAAWLLNDTVKNNILFNSPFN 800

  Fly   536 RRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAV 600
            ..||..||:.|.|:||||:|...|.|.:||:|.:||||||.|:|||||:|......||||.||||
Yeast   801 EARYKAVVEACGLKRDFEILKAGDLTEIGEKGITLSGGQKQRVSLARALYSNARHVLLDDCLSAV 865

  Fly   601 DTHVARHLFEQCMRGYLRE-RIVILATHQLQF-LQHADQIVIMDKGRVSAVGTYESLRESGLDFA 663
            |:|.|..:::.|:.|.|.| |..||.:|.:.. |::|:.:|:::.|||...|....:.:.|| |.
Yeast   866 DSHTASWIYDNCITGPLMEDRTCILVSHNIALTLRNAELVVLLEDGRVKDQGDPIDMLQKGL-FG 929

  Fly   664 SMLADPERDEQSEERSRSRSGSYTHSHSDQRRNSEQSLLSMADSCMDDL---------------- 712
                   .||..:....||:            ||..:|.:.:.:.:.:|
Yeast   930 -------EDELVKSSILSRA------------NSSANLAAKSSTSLSNLPAVKEQQVSVNNNSSH 975

  Fly   713 ------------EAEQANN-----QERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLA 760
                        |||:..:     :|.:|.|.:||.:|..|.|..||:.....:....:::| |.
Yeast   976 FEAKKLQKSLRTEAERTEDGKLIKEETKEEGVVGLDVYKWYLKIFGGWKIVSFLASLFLIAQ-LL 1039

  Fly   761 SLGDYFLSYWV-----------------------TKKGN--VAYRADNNDTTRSEELEPRLSTWL 800
            .:|.   |:||                       :||.:  :.:|..:..:..|.|.:|.
Yeast  1040 YIGQ---SWWVRAWASHNVIAKIIPRAQRAIAFISKKASHLIDWRGSSQISMASAENQPS----- 1096

  Fly   801 RDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTN 865
                 |..:.|....::.:|.....|:...::.|.|...:.||.::.|.:...:..:.:.||:..
Yeast  1097 -----SGHSTMYYLVLYLIIGFAQALLGAGKTILNFVAGINASRKIFNMILNKVLHSKIRFFDAT 1156

  Fly   866 PSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTF 930
            |:|||:||||||:..:|:.|...:.......:.....||:|..:.|.||...:|:.|::|.:..|
Yeast  1157 PTGRIMNRFSKDIEAIDQELTPYIQGAFYSLIECLSTVILITFITPQFLSVAIVVSILYYFVGYF 1221

  Fly   931 YLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQ-RVLEAEFDNYQDMHSSAFYMFISTS 994
            |:..||::||.|:|:|||:|.|.:.:|.|::||||||.: |.::.......:.:...||::::..
Yeast  1222 YMAGSRELKRFESISRSPIYQHFSETLVGVTTIRAFGDEGRFMQENLHKIDENNKPFFYLWVANR 1286

  Fly   995 RAFGYWLDCFCVIYIAIITL----SFFIFPPAN--GGDVGLAITQAMGMTGMVQWGMRQSAELEN 1053
                 || .|.:..|..:.:    .|.:|...|  .|..|:::|.|:..|....|.:|..:|:|.
Yeast  1287 -----WL-AFRIDMIGSLVIFGAGLFILFNINNLDSGMAGISLTYAISFTEGALWLVRLYSEVEM 1345

  Fly  1054 TMTAVERVVEYEDIEPEGALEAPADKK---PPKSWPEQGKIVFDELSLRYTPD-PKSENVLKSLS 1114
            .|.:||||.||.:||.|     |.::.   ||..||:.|||..::|||||.|: |:   |:|::|
Yeast  1346 NMNSVERVKEYMEIEQE-----PYNEHKEIPPPQWPQDGKIEVNDLSLRYAPNLPR---VIKNVS 1402

  Fly  1115 FVIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVL 1178
            |.:..:.|:|||||||||||::|.|||| |....|.:.||..|.|.:.|..||..|:||||:|.|
Yeast  1403 FSVDAQSKIGIVGRTGAGKSTIITALFRFLEPETGHIKIDNIDISGVDLQRLRRSITIIPQDPTL 1467

  Fly  1179 FSGTMRYNLDPFDEYSDDKLWRSLEEVKL-----------KEVVADLPS----------GLQSKI 1222
            ||||::.||||:||:||.:::.:|:.|.|           :|...:..|          .|.|:|
Yeast  1468 FSGTIKTNLDPYDEFSDRQIFEALKRVNLISEEQLQQGATRETSNEASSTNSENVNKFLDLSSEI 1532

  Fly  1223 TEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRL 1287
            :|||:|.|.|||||:||||::||..:|:::|||||::|..:|..||.|||.:|:..|:|||||||
Yeast  1533 SEGGSNLSQGQRQLMCLARSLLRSPKIILLDEATASIDYSSDAKIQETIRKEFQGSTILTIAHRL 1597

  Fly  1288 HTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTGHATYESLLKIAQKAFENRQN 1350
            .:::|.||:||||||...|:..||.|| |.....|:.|.:.:|.  .:.|:::|:|||..:.|
Yeast  1598 RSVIDYDKILVMDAGEVKEYDHPYSLL-LNKQSAFYSMCEHSGE--LDILIELAKKAFVEKLN 1657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	444/1454 (31%)
		ABC_membrane	107..360	CDD:294371	77/288 (27%)
		ABCC_MRP_domain1	445..645	CDD:213217	86/217 (40%)
		ABC_membrane	815..1014	CDD:294371	58/199 (29%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	115/243 (47%)
YBT1	NP_013052.1	MRP_assoc_pro	<353..1639	CDD:188098	432/1391 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344642
Domainoid	1	1.000	64	1.000	Domainoid score	I2425
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.640