DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and ABCC11

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_001319112.1	Gene:	ABCC11 / 839922	AraportID:	AT1G30420	Length:	1495	Species:	Arabidopsis thaliana

Alignment Length:	1368	Identity:	454/1368 - (33%)
Similarity:	723/1368 - (52%)	Gaps:	136/1368 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTKGKPN 77
            |..:.:..|...|.:..|....|.::.:..:|:::..:..::|||..:....|  ..|..:.||.
plant   228 PERYASIFSGIYFSWMTPLMQLGYRKPITERDVWQLDQWDQTETLIKRFQRCW--TEESRRPKPW 290

  Fly    78 LLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYTHGSESIESAYYYAAGVILCSAL 142
            |||||....|..|.|.|:.....:|. :.:.|:.|..::.....| :.....|.||..:......
plant   291 LLRALNNSLGRRFWLGGIFKVGHDLS-QFVGPVILSHILQSMIEG-DPAWVGYVYAFLIFFGVTF 353

  Fly   143 NVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVGRLDLATIFV 207
            .|:....|......||.::|..:.:.|:.|:|||:..|..:..:|.|.|:::.|...|.|....:
plant   354 GVLCQSQYFQHVGRVGFRLRSTLVAAIFHKSLRLTNKARKNFASGKVTNMITTDANALQLIAEQL 418

  Fly   208 HYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMN 272
            |.||..|...:....|:|:::|:|::||...:.|.||.|..:.::...|.......||:||.::.
plant   419 HGLWSAPFRIIVSMVLLYQQLGVASIFGSLILFLLIPFQTLIVRKMRKLTKEGLQWTDKRVGIIY 483

  Fly   273 EIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFLTRVSIFLSLVG-YVL 336
            ||::.:.::|.||||..||..:...|.:|::..|....: ....|||:..|.|.:.|...| |||
plant   484 EILASMDIVKCYAWEKSFESRIQGIRNEELSWFRKAQLL-SAFNSFILNSTPVVVTLVSFGVYVL 547

  Fly   337 LGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTE 401
            ||..|||..||...:.:.:||:.::. .|..|||.....||::|:::.:.|
plant   548 LGGDLTPARAFTSLSLFAVLRSPLST-LPNLISQAVNANVSLQRIEELLLS-------------- 597

  Fly   402 DFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGV 466
                           |||..|::..|.|           ....|||......||..:...:|:.:
plant   598 ---------------EERILAQNPPLQP-----------GAPAISIKNGYFSWDSKTSKPTLSDI 636

  Fly   467 NLRVQPGTMLGIVGRTGSGKSSLIQAILGELP-AESGEIKVNGSMSYASQEPWLFSGTVRQNILF 530
            ||.:..|:::.|||.||.||:|||.|:||||. ||:..:.:.||::|..|..|:|:.|:|:||||
plant   637 NLEIPVGSLVAIVGGTGEGKTSLISAMLGELSHAETSSVDIRGSVAYVPQVSWIFNATLRENILF 701

  Fly   531 GQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDD 595
            |...:..||.:.:...||:.|.:|.|.:|:|.:||||.::|||||.|:|:|||||..:.||:.||
plant   702 GSDFESERYWRAIDVTALQHDLDLFPGRDRTEIGERGVNISGGQKQRVSMARAVYSNSDIYIFDD 766

  Fly   596 PLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRESGL 660
            |.||:|.|||..:|:.|::..|:.:..:|.|:||.||...|:|:::.:|.:...|.:..|.:||.
plant   767 PFSALDAHVAHQVFDSCVKHELKGKTRVLVTNQLHFLPLMDRIILVSEGMIKEEGNFAELSKSGT 831

  Fly   661 DFASML-----ADPERDEQSEERSRSRSG-SYTHSHSDQRRNSEQ------SLLSMADSCMDDLE 713
            .|..::     .|..::..:.:.:.|:.| :.|...|::...|.|      |:|.
plant   832 LFKKLMENAGKMDATQEVNTNDENISKLGPTVTIDVSERSLGSIQQGKWGRSMLV---------- 886

  Fly   714 AEQANNQERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVA 778
                 .||.:|.|.|...:..:|.||.||.:...:::...:.::.|..|...:||.|
plant   887 -----KQEERETGIISWDVVMRYNKAVGGLWVVMILLVCYLTTEVLRVLSSTWLSIW-------- 938

  Fly   779 YRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKAS 843
                 .|.:..:...|         |..:       .::.::....:.||...||...:.::.|:
plant   939 -----TDQSTPKSYSP---------GFYI-------VVYALLGFGQVAVTFTNSFWLISSSLHAA 982

  Fly   844 IRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAV 908
            .|||::|...|.||.|.||.|||:||::||||||:|.:|..:..:|...:.....|.....:|.:
plant   983 KRLHDAMLNSILRAPMLFFETNPTGRVINRFSKDIGDIDRNVANLMNMFMNQLWQLLSTFALIGI 1047

  Fly   909 VNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGA-QRVL 972
            |:.:.|...:.|.|:||....:|..|||:|:|::::||||:|:....:|.|||:|||:.| .|:.
plant  1048 VSTISLWAIMPLLILFYATYIYYQSTSREVRRLDSVTRSPIYALFGEALNGLSSIRAYKAYDRMA 1112

  Fly   973 EAEFDNYQDMHSSAFYMFISTSRAFGYWLDC------FCVIYIAIITLSFFIFPPAN-------G 1024
            :.   |.:.|.::..:...|||.  ..||..      ..:|:   :|.:|.:....|       .
plant  1113 KI---NGKSMDNNIRFTLASTSS--NRWLTIRSESLGGVMIW---LTATFAVLRYGNAENQAVFA 1169

  Fly  1025 GDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSWPEQG 1089
            ..:||.::..:.:|.::...:||:::.||::.:||||..|.|: |..|.....:.:|...||.:|
plant  1170 STMGLLLSYTLNITTLLSGVLRQASKAENSLNSVERVGNYIDL-PSEATAIIENNRPVSGWPSRG 1233

  Fly  1090 KIVFDELSLRYTPD-PKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVLI 1152
            .|.|:::.|||.|. |.   ||..|||.:.|.||||:||||||||||::|||:|: ....|.:||
plant  1234 SIQFEDVHLRYRPGLPP---VLHGLSFFVYPSEKVGVVGRTGAGKSSMLNALYRIVELEKGRILI 1295

  Fly  1153 DKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSG 1217
            |..|.::.||.|||..:|||||.|||||||:|:|:|||.|::|..||.:||...:|:|:...|.|
plant  1296 DDYDVAKFGLTDLRRVLSIIPQSPVLFSGTVRFNIDPFSEHNDADLWEALERAHIKDVIDRNPFG 1360

  Fly  1218 LQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLT 1282
            |.::::|||.|||||||||:.||||:||.::||.:|||||:||.:||.|||.|||.:||.||:|.
plant  1361 LDAEVSEGGENFSVGQRQLLSLARALLRRSKILFLDEATASVDVRTDSLIQRTIREEFKSCTMLI 1425

  Fly  1283 IAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTGHATYESLLKIAQKAFEN 1347
            |||||:||:|.||:||:.:|:.:|:.:|.|||: .|:..|..||..||....:.|..:   .||.
plant  1426 IAHRLNTIIDCDKILVLSSGQVLEYDSPQELLS-RDTSAFFKMVHSTGPENGQYLSNL---VFER 1486

  Fly  1348 RQN 1350
            |.|
plant  1487 RGN 1489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	442/1331 (33%)
		ABC_membrane	107..360	CDD:294371	73/253 (29%)
		ABCC_MRP_domain1	445..645	CDD:213217	86/200 (43%)
		ABC_membrane	815..1014	CDD:294371	65/205 (32%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	124/222 (56%)
ABCC11	NP_001319112.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720