DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and ABCC15

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_191656.2	Gene:	ABCC15 / 825269	AraportID:	AT3G60970	Length:	1053	Species:	Arabidopsis thaliana

Alignment Length:	1209	Identity:	379/1209 - (31%)
Similarity:	603/1209 - (49%)	Gaps:	207/1209 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 MSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGK-----R 252
            ||.||.|:.....:|:.:|:.|::.....|::.:.:|:.|:..:...|:.:.....|.:     :
plant     1 MSVDVQRITDFIWYVNSIWMLPIQIFSAIYILQKHLGLGALAALVTTLMVMACNYPLTRLQRNYQ 65

  Fly   253 TSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEIN----AIRHVSYIRG 313
            :.::..:     |:|::..:||:..::::|:.||:..|.:.|...||||.:    ::|...:...
plant    66 SDIMNAK-----DDRMKATSEILKNMKILKLQAWDNQFLNKVKTLRKKEYDCLWKSLRLQDFTTF 125

  Fly   314 I------LLSFIIFLTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVF-FPQGISQM 371
            |      |:|.:.|:|          .:|:|..||........|.:.:|::  .:| .|..:|.:
plant   126 ILWGAPSLISVVTFVT----------CMLMGVKLTAGAVLSALATFQMLQS--PIFGLPDLLSAL 178

  Fly   372 AETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNE 436
            .::.||..|:..|:|..||                           ::|..|        ...|:
plant   179 VQSKVSADRIASYLQQSET---------------------------QKDAVE--------YCSND 208

  Fly   437 NAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAES 501
            :.:.|   :.|......|:..|...:|:.:.|:|:.|..:.|.|..|||||||..:||||:....
plant   209 HTEFS---VEIENGAFSWEPESSRPTLDDIELKVKSGMKVAICGAVGSGKSSLPSSILGEIQKLK 270

  Fly   502 GEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGER 566
            |.::|:|..:|..|.||:.|||:|.|||||...:..:|.:.||.|||.:||||....|.|.:|||
plant   271 GTVRVSGKQAYVPQSPWILSGTIRDNILFGSIYESEKYERTVKACALIKDFELFSNGDLTEIGER 335

  Fly   567 GASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQF 631
            |.::|||||.||.:|||||:...|||||||.||||.|..|.|||.|:.|.|:::.|:..|||::|
plant   336 GINMSGGQKQRIQIARAVYQNADIYLLDDPFSAVDAHTGRELFEDCLMGILKDKTVLYVTHQVEF 400

  Fly   632 LQHADQIVIMDKGRVSAVGTYESLRESGLDFASML-ADPERDEQSEERSRSRSGSYTHSHSDQRR 695
            |..||.|::|..|||...|.:|.|.:..:.|..:. .|.|                 |:.|.:.:
plant   401 LPAADLILVMQNGRVMQAGKFEELLKQNIGFEVLTQCDSE-----------------HNISTENK 448

  Fly   696 NSEQSLLSMADSCMDDLEAEQANNQERQEAGQIGLRLYSKYFKA--GGGFFAFFVMMGFCVLSQG 758
            ..|..|:                ..|..|.|.||..:|..|...  ||....|.::...|.....
plant   449 KKEAKLV----------------QDEETEKGVIGKEVYLTYLTTVKGGLLVPFIILAQSCFQMLQ 497

  Fly   759 LASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVL 823
            :||      :||      :|:.|            |..:..:..:|:   ..:|  .::.::...
plant   498 IAS------NYW------MAWTA------------PPTAESIPKLGM---GRIL--LVYALLAAG 533

  Fly   824 TILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAV 888
            :.|..:||:.|.....:..:....:.|...|.||.|.:|::.|:||||||.|.|...:| :..||
plant   534 SSLCVLARTILVAIGGLSTAETFFSRMLCSIFRAPMSYFDSTPTGRILNRASTDQSVLD-LEMAV 597

  Fly   889 MM-----DVIQIFLALAGIVIVIAVVN---PLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAIT 945
            .:     .:|||    .|.:.|::.|.   .:..|| |.:..:|||  .:|..|.|::.||..:.
plant   598 KLGWCAFSIIQI----VGTIFVMSQVAWQVCVIFIP-VAVACVFYQ--RYYTPTERELSRMSGVE 655

  Fly   946 RSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNY-------QDMHSSAFYMFISTSRAFGYWLD- 1002
            |:|:..|.|.||.|.:|||||. ||      |.:       .|.||..::...|......:.|:
plant   656 RAPILHHFAESLAGATTIRAFD-QR------DRFISSNLVLIDSHSRPWFHVASAMEWLSFRLNL 713

  Fly  1003 ----CFCVIYIAIITLSFFIFPPANGGDVGLAITQAMGMT---GMVQWGMRQSAELENTMTAVER 1060
                .|....:.::||...:..|:   ..||.:|..:.:.   ..|.|.:   ...||.|.:|||
plant   714 LSHFVFAFSLVLLVTLPEGVINPS---IAGLGVTYGLSLNVLQATVIWNI---CNAENKMISVER 772

  Fly  1061 VVEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSEN---VLKSLSFVIKPKEK 1122
            ::::..|..|..|... |::|..:||..|.|||.:|.:||     :|:   |||:::......:|
plant   773 ILQHSKIPSEAPLVID-DQRPLDNWPNVGSIVFRDLQVRY-----AEHFPAVLKNITCAFPGGKK 831

  Fly  1123 VGIVGRTGAGKSSLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYN 1186
            :|:|||||:|||:||.||||: ..:.|:::||..|.:::|||||||::.||||:..||.||:|.|
plant   832 IGVVGRTGSGKSTLIQALFRIVEPSHGTIVIDNVDITKIGLHDLRSRLGIIPQDNALFDGTIRLN 896

  Fly  1187 LDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILV 1251
            |||..:|:|.::|.:|::.:|.:|:......|.:.:.|.|.|:||||||||||.|.:|:::.|||
plant   897 LDPLAQYTDREIWEALDKCQLGDVIRAKDEKLDATVVENGENWSVGQRQLVCLGRVLLKKSNILV 961

  Fly  1252 MDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTL 1316
            :|||||:||..|||:||..|..:||:.||:|||||:||:::||.|||:..||..||.:|.:||..
plant   962 LDEATASVDSATDGVIQKIINQEFKDRTVVTIAHRIHTVIESDLVLVLSDGRIAEFDSPAKLLQR 1026

  Fly  1317 ADSKVFHGMVKQTGHATYESLLKIAQKAFENRQNHSLSS 1355
            .|| .|..::|:                :..|.||...|
plant  1027 EDS-FFSKLIKE----------------YSLRSNHFAGS 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	370/1167 (32%)
		ABC_membrane	107..360	CDD:294371	38/181 (21%)
		ABCC_MRP_domain1	445..645	CDD:213217	93/199 (47%)
		ABC_membrane	815..1014	CDD:294371	60/218 (28%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	109/224 (49%)
ABCC15	NP_191656.2	ABC_membrane	<1..170	CDD:294371	38/185 (21%)
		EcfA2	214..428	CDD:224047	99/213 (46%)
		ABCC_MRP_domain1	214..414	CDD:213217	93/199 (47%)
		MdlB	481..1037	CDD:224055	207/612 (34%)
		ABC_membrane	520..756	CDD:294371	67/258 (26%)
		ABCC_MRP_domain2	800..1020	CDD:213211	109/224 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720