DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and ABCC10

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_191473.2	Gene:	ABCC10 / 825083	AraportID:	AT3G59140	Length:	1453	Species:	Arabidopsis thaliana

Alignment Length:	1368	Identity:	416/1368 - (30%)
Similarity:	668/1368 - (48%)	Gaps:	199/1368 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSET---------------LGNK---------- 60
            |...||:......:|..:.|:.:|:....||.::||               ||:.
plant   214 STLSFWWLNSLIKRGNVKDLEEEDIPELRKEERAETCYSLFEENLIEQKRRLGSSCQPSILKVTV 278

  Fly    61 LCASWEL---------ELEKTKGKPNLLRALLRVF--GWYFALLGLVLFLLELGLRTLQPIFLLK 114
            ||...||         ::......|.||.|.:.|.  ...|...||||.:|         :|..|
plant   279 LCVWRELLTSGFFAFMKIVAVSAGPLLLNAFILVAEGNASFRYEGLVLAVL---------LFFSK 334

  Fly   115 LIAYYTHGSESIESAYYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKS 179
            :|       ||:....:|    ..|..               |||::|..:.:.|.:|.|||:.|
plant   335 MI-------ESLSQRQWY----FRCRI---------------VGLRVRSLLTAAINKKQLRLNNS 373

  Fly   180 ALGDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIP 244
            :....:...::|..:.|..|:.....:.|.||....:.|....:::..:|:|....:|.::|.:.
plant   374 SRLIHSGSEIMNYATVDAYRIGEFPYWFHQLWTTSFQLLIALGILFHSVGVATFSALAVIILTVL 438

  Fly   245 LQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVS 309
            ..|.:.|..:..:.......|||::..||.:..::|:|:||||..|:.::...|..|:.:::.|.
plant   439 CNAPIAKLQNKFQSELMTSQDERLKACNESLVNMKVLKLYAWESHFKKVIEKLRNIELKSLKAVQ 503

  Fly   310 YIRGILLSFIIFLTRVSIFLSLVGYVLLGTFLT------PEVAFLITAYYNILRTTM--TVFFPQ 366
            ..:..         ...:|.|...:|...||.|      |..|..:..:...||...  ....|.
plant   504 MRKAY---------NAVLFWSSPVFVSAATFATCYFLDIPLRASNVFTFVATLRLVQDPVRMIPD 559

  Fly   367 GISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPI 431
            .|....:..|:..|:..::::.|             .||         |:..|.:..:.
plant   560 VIGVTIQAKVAFSRIATFLEAPE-------------LQG---------GERRRKQRSEG------ 596

  Fly   432 ATVNENAKLSEAGISISGLMAKW-DVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILG 495
               |:||      |.|......| :..|...:|..|:|.|:.|..:.:.|..|||||:|:.||||
plant   597 ---NQNA------IIIKSASFSWEEKGSTKPNLRNVSLEVKFGEKVAVCGEVGSGKSTLLAAILG 652

  Fly   496 ELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDK 560
            |.|..||.|...|:::|.||..|:.:||:|.|||||..||..||.:.::|.:|::|.||||..|:
plant   653 ETPCVSGTIDFYGTIAYVSQTAWIQTGTIRDNILFGGVMDEHRYRETIQKSSLDKDLELLPDGDQ 717

  Fly   561 TIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILA 625
            |.:||||.:||||||.||.||||:|::..|||||||.||||.|.|..||::.:...|..:.|:|.
plant   718 TEIGERGVNLSGGQKQRIQLARALYQDADIYLLDDPFSAVDAHTASSLFQEYVMDALAGKAVLLV 782

  Fly   626 THQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLDFASMLADPERDEQSEERSRSRSGSYTHSH 690
            |||:.||...|.:::|..|.::...||:.|.....||.. |.:..|:....||..:.........
plant   783 THQVDFLPAFDSVLLMSDGEITEADTYQELLARSRDFQD-LVNAHRETAGSERVVAVENPTKPVK 846

  Fly   691 SDQRRNSEQSLLSMADSCMDDLEAEQANNQERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVL 755
            ...|..|.||.:         |:..:...||.:|.|..|||.|.:|.....|:..||:    ..|
plant   847 EINRVISSQSKV---------LKPSRLIKQEEREKGDTGLRPYIQYMNQNKGYIFFFI----ASL 898

  Fly   756 SQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVI 820
            :|...::|....:.|      :|...||          |::|| |:.|           .::.:|
plant   899 AQVTFAVGQILQNSW------MAANVDN----------PQVST-LKLI-----------LVYLLI 935

  Fly   821 TVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEIL 885
            .:.::|..:.||.....:.||:|..|.:.:...:.||.|.|:::.|.||||:|.|.|:..||..:
plant   936 GLCSVLCLMVRSVCVVIMCMKSSASLFSQLLNSLFRAPMSFYDSTPLGRILSRVSSDLSIVDLDV 1000

  Fly   886 PAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVY 950
            |..::.|:...:.....:.|:|:|....|..:|.:..:.::|:.:|.:|::::.|:...|||.|.
plant  1001 PFGLIFVVASSVNTGCSLGVLAIVTWQVLFVSVPMVYLAFRLQKYYFQTAKELMRINGTTRSYVA 1065

  Fly   951 SHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWL-------------- 1001
            :|||.|:.|..|||||..:.....:.....|.::|.|:    .|.|...||
plant  1066 NHLAESVAGAITIRAFDEEERFFKKSLTLIDTNASPFF----HSFAANEWLIQRLETVSAIVLAS 1126

  Fly  1002 DCFCVIYIAIITLSFFIFPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYED 1066
            ..||:|.:...|.|        .|.:|:|::..:.:...:.:.::....|.|.:.:|||:.:|..
plant  1127 TAFCMILLPTGTFS--------SGFIGMALSYGLSLNMGLVYSVQNQCYLANWIISVERLNQYTH 1183

  Fly  1067 IEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGA 1131
            :.|| |.|...:.:||.:||..|::...:|.:||..:  |..|||.:|...:...|:|||||||:
plant  1184 LTPE-APEVIEETRPPVNWPVTGRVEISDLQIRYRRE--SPLVLKGISCTFEGGHKIGIVGRTGS 1245

  Fly  1132 GKSSLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSD 1195
            ||::||:||||| ....|.:::|..|.|::|:|||||:..||||:|.||:||:|:||||..::||
plant  1246 GKTTLISALFRLVEPVGGKIVVDGVDISKIGVHDLRSRFGIIPQDPTLFNGTVRFNLDPLCQHSD 1310

  Fly  1196 DKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVD 1260
            .::|..|.:.:|||||.:..:||.|.:.|.|:|:|:|||||.||.||:||.:|:||:|||||::|
plant  1311 AEIWEVLGKCQLKEVVQEKENGLDSLVVEDGSNWSMGQRQLFCLGRAVLRRSRVLVLDEATASID 1375

  Fly  1261 PQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGM 1325
            ..||.::|.|||.:|.:|||:|:|||:.|:||...||.:..||.||:..|.:|:. .::.:|..:
plant  1376 NATDLILQKTIRREFADCTVITVAHRIPTVMDCTMVLSISDGRIVEYDEPMKLMK-DENSLFGKL 1439

  Fly  1326 VKQ 1328
            ||:
plant  1440 VKE 1442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	413/1353 (31%)
		ABC_membrane	107..360	CDD:294371	55/258 (21%)
		ABCC_MRP_domain1	445..645	CDD:213217	93/200 (47%)
		ABC_membrane	815..1014	CDD:294371	57/212 (27%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	109/221 (49%)
ABCC10	NP_191473.2	MRP_assoc_pro	194..1437	CDD:188098	413/1361 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	64	1.000	Domainoid score	I3649
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720