DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and ABCC8

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_001326629.1	Gene:	ABCC8 / 821679	AraportID:	AT3G21250	Length:	1470	Species:	Arabidopsis thaliana

Alignment Length:	1373	Identity:	404/1373 - (29%)
Similarity:	677/1373 - (49%)	Gaps:	194/1373 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPENPREH------CNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWEL 67
            |.:|||:.      ..|.|...|.:..|....|.|:.|..:|:...:.|.:::....|...:|:.
plant   198 LTKNPRKESARLATAGFFSILSFSWMNPLLSLGFKKPLSPEDIPSVVPEDEAQLAYKKFSQAWDT 262

  Fly    68 EL---EKTKGKPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYTHGSESIESA 129
            .|   ..||.:..:.||:::|:......:.:..||....:.:| |:.|...:.|.......:.:.
plant   263 LLGDESSTKERNLVFRAVVKVYFKENIFIAVFAFLRTFAVVSL-PLMLYVFVDYANSDHRDLRNG 326

  Fly   130 YYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMS 194
            ::..|.:::...:..:.|..:...:...|:::|..:....|:|.|:||.......::|.:||.::
plant   327 FFNLACLVMLKLVESLTMRHWYFASRRSGMRIRSALMVAAYKKQLKLSSLGRKRHSSGEIVNYIA 391

  Fly   195 NDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLR 259
            .|..|:.....:.|..|...|:.|..|.:::..:|..|..|:..:||...|.....|.....:.:
plant   392 VDAYRMGEFLWWFHSGWSLSLQLLLSTAVLFGVVGAGAFPGLILLLLCGLLNLPFAKMLQNCQTQ 456

  Fly   260 TALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGI---------- 314
            ..:..|:|:|..:||::.::|||:.:||..|:..:...|..|...:......:..
plant   457 FMIAQDKRLRSTSEILNSMKVIKLQSWEDEFKKKIESCRDDEFTWLAKAQLTKAFGSFLYWMSPT 521

  Fly   315 LLSFIIFLTRVSIFLSLVGYVLLGTF-LTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSI 378
            ::|.::||          |..||.:. |.....|.:.|...::...:.: .|..||.:.:..||.
plant   522 IVSSVVFL----------GCALLKSAPLNASTIFTVLATLRVMSEPVKI-IPDAISAIIQGNVSF 575

  Fly   379 KRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEA 443
            :|:..::..||..:                           ||.|                  .:
plant   576 QRLNNFLLDDELKM---------------------------DEIE------------------RS 595

  Fly   444 GISISGLMAK-------WDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAES 501
            |:..||....       |:..:...:|..::|.::.|..:.:.|..|:|||||:.|:|||:|..|
plant   596 GLDASGTAVDIQVGNFGWEPETKIPTLRNIHLEIKHGQKVAVCGPVGAGKSSLLHAVLGEIPKVS 660

  Fly   502 GEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGER 566
            |.:||.||::|.||..|:.|||:|.|||:|:||:.|||...:|.|||::|.......|.|.:|:|
plant   661 GTVKVFGSIAYVSQTSWIQSGTIRDNILYGKPMESRRYNAAIKACALDKDMNGFGHGDLTEIGQR 725

  Fly   567 GASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQF 631
            |.:||||||.||.||||||.:..:||||||.||||.|.|..||.:|:...|:|:.|||.|||::|
plant   726 GINLSGGQKQRIQLARAVYADADVYLLDDPFSAVDAHTAGVLFHKCVEDSLKEKTVILVTHQVEF 790

  Fly   632 LQHADQIVIMDKGRVSAVGTYESLRESGLDFASMLADPERDEQSEERSRSRSGSYTHSHSD---- 692
            |...|||::|::|.::..|.||.|...|..|..::                     ::|:|
plant   791 LSEVDQILVMEEGTITQSGKYEELLMMGTAFQQLV---------------------NAHNDAVTV 834

  Fly   693 ------------QRRNSEQSLLSMADSCMDDLEAE---------QANNQERQEAGQIGLRLYSKY 736
                        ::...::.:.:|  :.::.:|.|         |...:|.:|:|.:|::.:..|
plant   835 LPLASNESLGDLRKEGKDREIRNM--TVVEKIEEEIEKTDIPGVQLTQEEEKESGYVGMKPFLDY 897

  Fly   737 FKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLR 801
            ..         |..|:|:|              |.:..|.|.:..          .:...:.||.
plant   898 IG---------VSRGWCLL--------------WSSVLGQVGFVV----------FQAASTYWLA 929

  Fly   802 -DIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTN 865
             .||:......:...::::|:.|:.....||:....:|.:|||....:.....:.:|.|.||::.
plant   930 FAIGIPKITNTMLIGVYSIISTLSAGFVYARAITTAHLGLKASKAFFSGFTNAVFKAPMLFFDST 994

  Fly   866 PSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTF 930
            |.||||.|.|.|:..:|..:|...:.|:...:.|...::::..|....:|..::.......::.:
plant   995 PVGRILTRASSDLNVLDYDVPFAFIFVVAPAVELTAALLIMTYVTWQVIIIALLALAATKVVQDY 1059

  Fly   931 YLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSR 995
            ||.::|::.|:...|::||.::.|.:..|:.||||||   ..|..|.||.::..:...:|..::.
plant  1060 YLASARELIRINGTTKAPVMNYAAETSLGVVTIRAFG---TAERFFKNYLNLVDADAVLFFLSNA 1121

  Fly   996 AFGYW----------LDCFCVIYIAIITLSFFIFPPANGGDVGLAITQAMGMTGMVQWGMRQSAE 1050
            |. .|          :..|....:.|:....:|.|    |.|||:::.|:.:|....:..|....
plant  1122 AM-EWVILRIETLQNVTLFTCALLLILIPKGYIAP----GLVGLSLSYALTLTQTQVFLTRWYCT 1181

  Fly  1051 LENTMTAVERVVEYEDIEPEGALEAPA---DKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKS 1112
            |.|::.:|||:.:|.:| ||   |.||   ||:||.|||..|.|...||.:||.|:  :..|||.
plant  1182 LSNSIISVERIKQYMNI-PE---EPPAIIDDKRPPSSWPSNGTIHLQELKIRYRPN--APLVLKG 1240

  Fly  1113 LSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEP 1176
            :|...:...:||:|||||:|||:||:||||| ....|.:|||..|.|::||.|||.|:|||||||
plant  1241 ISCTFREGTRVGVVGRTGSGKSTLISALFRLVEPASGCILIDGIDISKIGLKDLRMKLSIIPQEP 1305

  Fly  1177 VLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLAR 1241
            .||.|.:|.||||...||||::|::||:.:||..:::||:.|.|.:::.|.|:|||||||.||.|
plant  1306 TLFRGCIRTNLDPLGVYSDDEIWKALEKCQLKTTISNLPNKLDSSVSDEGENWSVGQRQLFCLGR 1370

  Fly  1242 AILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVE 1306
            .:|:.|:|||:|||||::|..||.:||..||.:|.:|||:|:|||:.|::|||.|:|:..|..||
plant  1371 VLLKRNKILVLDEATASIDSATDAIIQRIIREEFADCTVITVAHRVPTVIDSDMVMVLSFGDLVE 1435

  Fly  1307 FGTPYELL 1314
            :..|.:|:
plant  1436 YNEPSKLM 1443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	403/1370 (29%)
		ABC_membrane	107..360	CDD:294371	52/263 (20%)
		ABCC_MRP_domain1	445..645	CDD:213217	94/206 (46%)
		ABC_membrane	815..1014	CDD:294371	50/208 (24%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	114/221 (52%)
ABCC8	NP_001326629.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720