DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and ABCC4

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_182301.1	Gene:	ABCC4 / 819392	AraportID:	AT2G47800	Length:	1516	Species:	Arabidopsis thaliana

Alignment Length:	1332	Identity:	440/1332 - (33%)
Similarity:	705/1332 - (52%)	Gaps:	139/1332 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FWYTM-PTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTKGKPNLLRALLRVFGW 88
            ||..| |...||.|..|..:.:.....|||:|.|.....:||....|.:...  :...|||.| |
plant   262 FWLWMNPLLSKGYKSPLTLEQVPTLSPEHKAERLALLFESSWPKPSENSSHP--IRTTLLRCF-W 323

  Fly    89 YFALLGLVLFLLELGLRTLQPIFLLKLIAYYTHGSESIESAYYYAAGVILCSALNVIIMHPYMLG 153
            ...|...:|.::.||:..:.|:.:...:.:.:....|....||....:::...:.|:..|.:...
plant   324 KEILFTAILAIVRLGVMYVGPVLIQSFVDFTSGKRSSPWQGYYLVLILLVAKFVEVLTTHQFNFD 388

  Fly   154 TMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETL 218
            :..:|:.:|..:.:.:|:|.|:|:.||..:...|.:||.|:.|..:|....:.:|.:|:.||:..
plant   389 SQKLGMLIRSTLITALYKKGLKLTGSARQNHGVGQIVNYMAVDAQQLSDMMLQLHAIWLMPLQVT 453

  Fly   219 FITYLMYREIG---IAAVFGVAFMLLFIPL--QAYLGKRTSVLRLRTALRTDERVRMMNEIISGI 278
            ....|:|..:|   |.||.|:..:.:||.|  |...|.:.|::..|     |.|::..||:::.:
plant   454 VALVLLYGSLGASVITAVIGLTGVFVFILLGTQRNNGYQFSLMGNR-----DSRMKATNEMLNYM 513

  Fly   279 QVIKMYAWELPFEHMVAFARKKEINAIRHVSY-IRG---------ILLSFIIFLTRVSIFLSLVG 333
            :|||..|||..|...:...|..|...:....| |.|         :|:|.:.|.|.::
plant   514 RVIKFQAWENHFNKRILKFRDMEFGWLSKFLYSIAGNIIVLWSTPVLISALTFATALA------- 571

  Fly   334 YVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVD 398
               ||..|.....|..|..:.||:..:.. |||.:..:::.::|:.|:..||         ||.:
plant   572 ---LGVKLDAGTVFTTTTIFKILQEPIRT-FPQSMISLSQAMISLGRLDSYM---------MSKE 623

  Fly   399 LTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSL 463
            |:||                   |.::.||   ...|...::.:...|       ||....:.:|
plant   624 LSED-------------------AVERALG---CDGNTAVEVRDGSFS-------WDDEDNEPAL 659

  Fly   464 NGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNI 528
            :.:|.:|:.|.:..|||..|||||||:.::|||:...||:::|.||..|.:|..|:.:|||:.||
plant   660 SDINFKVKKGELTAIVGTVGSGKSSLLASVLGEMHRISGQVRVCGSTGYVAQTSWIENGTVQDNI 724

  Fly   529 LFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLL 593
            |||.||.|.:|.||:..|:||:|.:::.|.|||.:||||.:||||||.||.||||||:|..:|||
plant   725 LFGLPMVREKYNKVLNVCSLEKDLQMMEFGDKTEIGERGINLSGGQKQRIQLARAVYQECDVYLL 789

  Fly   594 DDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRES 658
            ||..||||.|....:|::|:||.|:.:.|:|.|||:.||.:.|.|::|..|::...|.|:.|..|
plant   790 DDVFSAVDAHTGSDIFKKCVRGALKGKTVLLVTHQVDFLHNVDCILVMRDGKIVESGKYDELVSS 854

  Fly   659 GLDFASMLADPERDEQSEERSRSRSGSYTHSHSDQRRNSEQSLLSMADSCMDDLEAEQANN---- 719
            ||||..::|..|...:..|.....:...|...:....::.....||....:.||..|...:
plant   855 GLDFGELVAAHETSMELVEAGADSAAVATSPRTPTSPHASSPRTSMESPHLSDLNDEHIKSFLGS 919

  Fly   720 -----------QERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTK 773
                       :|.:|.||:.|.:|.:|.....|::...:::.|.:..||.....||:|:|..:.
plant   920 HIVEDGSKLIKEEERETGQVSLGVYKQYCTEAYGWWGIVLVLFFSLTWQGSLMASDYWLAYETSA 984

  Fly   774 KGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNL 838
            |..:::.|               |.::  :|            :.:|.:::|::...||:...:|
plant   985 KNAISFDA---------------SVFI--LG------------YVIIALVSIVLVSIRSYYVTHL 1020

  Fly   839 AMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIV 903
            .:|.:......:...|..|.|.||:|.||||||:|.|.|...||.::|.::..|:.::..|..|.
plant  1021 GLKTAQIFFRQILNSILHAPMSFFDTTPSGRILSRASTDQTNVDILIPFMLGLVVSMYTTLLSIF 1085

  Fly   904 IV---IAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRA 965
            ||   .|.....|:||   ||.:....|.:||.:||::.||::||::|:..|.:.|:.|:.|||:
plant  1086 IVTCQYAWPTAFFVIP---LGWLNIWYRNYYLASSRELTRMDSITKAPIIHHFSESIAGVMTIRS 1147

  Fly   966 FGAQRVLEAE-----FDNYQ-DMHSSAFYMFIS-TSRAFGYWLDCFCVIYIAIITLSFFIFPPAN 1023
            |..|.:...|     .||.: |.|::....::. .....|.|:.|...:::.::..:  :..|.|
plant  1148 FRKQELFRQENVKRVNDNLRMDFHNNGSNEWLGFRLELVGSWVLCISALFMVLLPSN--VIRPEN 1210

  Fly  1024 GGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSWPEQ 1088
               |||:::..:.:..::.:.:..|..:||.|.:|||:.::.||..|...|. .:..||.:||..
plant  1211 ---VGLSLSYGLSLNSVLFFAIYMSCFVENKMVSVERIKQFTDIPSESEWER-KETLPPSNWPFH 1271

  Fly  1089 GKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVLI 1152
            |.:..::|.:||.|:  :..|||.::..||..||||:|||||:|||:||..|||| ..:.|.::|
plant  1272 GNVHLEDLKVRYRPN--TPLVLKGITLDIKGGEKVGVVGRTGSGKSTLIQVLFRLVEPSGGKIII 1334

  Fly  1153 DKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSG 1217
            |..|.|.:|||||||:..|||||||||.||:|.|:||.::|||:::|:|||..:||:|||..|..
plant  1335 DGIDISTLGLHDLRSRFGIIPQEPVLFEGTVRSNIDPTEQYSDEEIWKSLERCQLKDVVATKPEK 1399

  Fly  1218 LQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLT 1282
            |.|.:.:.|.|:|||||||:||.|.:|:.:|:|.:|||||:||.|||.:||..||..|..||:::
plant  1400 LDSLVVDNGENWSVGQRQLLCLGRVMLKRSRLLFLDEATASVDSQTDAVIQKIIREDFASCTIIS 1464

  Fly  1283 IAHRLHTIMDSDKVLVMDAGRAVEFGTPYELL 1314
            ||||:.|:||.|:|||:|||:|.||.:|..||
plant  1465 IAHRIPTVMDGDRVLVIDAGKAKEFDSPARLL 1496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	440/1332 (33%)
		ABC_membrane	107..360	CDD:294371	65/267 (24%)
		ABCC_MRP_domain1	445..645	CDD:213217	94/199 (47%)
		ABC_membrane	815..1014	CDD:294371	61/208 (29%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	119/221 (54%)
ABCC4	NP_182301.1	CFTR_protein	255..1502	CDD:273530	440/1332 (33%)
		ABC_membrane	331..595	CDD:294371	68/278 (24%)
		ABCC_MRP_domain1	641..841	CDD:213217	94/206 (46%)
		ABC_membrane	976..1229	CDD:294371	73/289 (25%)
		ABCC_MRP_domain2	1272..1492	CDD:213211	119/221 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720