DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and ABCC2

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_001189675.1	Gene:	ABCC2 / 818031	AraportID:	AT2G34660	Length:	1623	Species:	Arabidopsis thaliana

Alignment Length:	1397	Identity:	491/1397 - (35%)
Similarity:	737/1397 - (52%)	Gaps:	179/1397 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELELEKTKGKPN 77
            |.:|.|......|.:..|....|.||.|..||::......::|||......||:.||:|.  :|.
plant   227 PEKHANIFDKIFFSWMNPLMTLGSKRPLTEKDVWYLDTWDQTETLFTSFQHSWDKELQKP--QPW 289

  Fly    78 LLRALLRVFGWYFALLGLVLFLLELGLRTLQ---PIFLLKLIAYYTHGSESIES------AYYYA 133
            |||||....|..|...|    ..::|....|   |:.|.:|:       :|::.      .|.||
plant   290 LLRALNNSLGGRFWWGG----FWKIGNDCSQFVGPLLLNQLL-------KSMQEDAPAWMGYIYA 343

  Fly   134 AGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSNDVG 198
            ..:.:.....|:....|....|.||.::|..:.:.::||:|||:.........|.:.|||:.|..
plant   344 FSIFVGVVFGVLCEAQYFQNVMRVGYRLRSALIAAVFRKSLRLTNEGRRKFQTGKITNLMTTDAE 408

  Fly   199 RLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRTALR 263
            .|......:|.:|..|...:....|:|:::|:|::.|...::|..|||..:..:...|......|
plant   409 SLQQICQSLHTMWSAPFRIIIALILLYQQLGVASLIGALLLVLMFPLQTVIISKMQKLTKEGLQR 473

  Fly   264 TDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFLTRVSIF 328
            ||:|:.:|||:::.:..:|.||||..|:..|...|..|::..|. |.:.|.|..||  |..:.:.
plant   474 TDKRIGLMNEVLAAMDTVKCYAWENSFQSKVQTVRDDELSWFRK-SQLLGALNMFI--LNSIPVL 535

  Fly   329 LSLVG---YVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDET 390
            :::|.   :.|||..|||..||...:.:.:||..: ...|..|:|:....||:||:::.:.::|.
plant   536 VTIVSFGVFTLLGGDLTPARAFTSLSLFAVLRFPL-FMLPNIITQVVNANVSLKRLEEVLATEER 599

  Fly   391 NVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAGISISGLMAKWD 455
            .:                                 |..|||       :..|..|||......||
plant   600 IL---------------------------------LPNPPI-------EPGEPAISIRNGYFSWD 624

  Fly   456 VNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEI-KVNGSMSYASQEPWL 519
            ......:|:.:||.|..|:::.:||.||.||:|||.||||||||.|..| .:.||::|..|..|:
plant   625 SKGDRPTLSNINLDVPLGSLVAVVGSTGEGKTSLISAILGELPATSDAIVTLRGSVAYVPQVSWI 689

  Fly   520 FSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAV 584
            |:.|||.|||||.|.||.:|.:.:...:|:.|.||||..|.|.:||||.::|||||.|:|:||||
plant   690 FNATVRDNILFGSPFDREKYERAIDVTSLKHDLELLPGGDLTEIGERGVNISGGQKQRVSMARAV 754

  Fly   585 YRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHADQIVIMDKGRVSAV 649
            |..:.:|:.||||||:|.||.:.:||:|::..|.::..:|.|:||.||...|:||::.:|.|...
plant   755 YSNSDVYIFDDPLSALDAHVGQQVFEKCIKRELGQKTRVLVTNQLHFLSQVDRIVLVHEGTVKEE 819

  Fly   650 GTYESLRESGLDFASMLADPER-DEQSEERSRSRSGSYTHSHSDQR-----RNSEQSLLSMADSC 708
            ||||.|..:|..|..::.:..: :|.|||..        .:.:||.     .|...:.|.|..|
plant   820 GTYEELSSNGPLFQRLMENAGKVEEYSEENG--------EAEADQTAEQPVANGNTNGLQMDGS- 875

  Fly   709 MDDLEAEQAN---------NQERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGD 764
             ||.::::.|         .||.:|.|.:..|:..:|..|.||  |:.|||
plant   876 -DDKKSKEGNKKGGKSVLIKQEERETGVVSWRVLKRYQDALGG--AWVVMM-------------- 923

  Fly   765 YFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWL---RDIGL-SVDAEMLDTYIFTVITVLTI 825
            ..|.|.:|:    .:|..:             ||||   .|.|. .....:....|:.:::...:
plant   924 LLLCYVLTE----VFRVTS-------------STWLSEWTDAGTPKSHGPLFYNLIYALLSFGQV 971

  Fly   826 LVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMM 890
            |||:..|:.....::.|:.:||::|...|.||.|.||:|||.|||:|||:||:|.:|..: ||.
plant   972 LVTLTNSYWLIMSSLYAAKKLHDNMLHSILRAPMSFFHTNPLGRIINRFAKDLGDIDRTV-AVF- 1034

  Fly   891 DVIQIFLA----LAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYS 951
              :.:|:.    |...|::|.:|:.|.|...:.|.::||....:|..|:|:||||::|:|||||:
plant  1035 --VNMFMGQVSQLLSTVVLIGIVSTLSLWAIMPLLVLFYGAYLYYQNTAREVKRMDSISRSPVYA 1097

  Fly   952 HLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAF-------YMFISTSRAFGYWLDCFCVIYI 1009
            ....:|.|||||||:.|       :|...|::..:.       .:.:..:|..|..|:....:.|
plant  1098 QFGEALNGLSTIRAYKA-------YDRMADINGRSMDNNIRFTLVNMGANRWLGIRLETLGGLMI 1155

  Fly  1010 AIITLSFFIFPPANG---------GDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYE 1065
             .:|.||.:.  .||         ..:||.::.|:.:|.::...:|.::..||::.|||||..|.
plant  1156 -WLTASFAVM--QNGRAENQQAFASTMGLLLSYALNITSLLTGVLRLASLAENSLNAVERVGNYI 1217

  Fly  1066 DIEPEGALEAP---ADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVG 1127
            :|.|    |||   .:.:||..||..|.|.|:::.|||.  |:...||..:||.|.|.:||||||
plant  1218 EIPP----EAPPVIENNRPPPGWPSSGSIKFEDVVLRYR--PQLPPVLHGVSFFIHPTDKVGIVG 1276

  Fly  1128 RTGAGKSSLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFD 1191
            |||||||||:|||||: ....|.:|||..|..:.||.|||..:.||||.|||||||:|:|||||.
plant  1277 RTGAGKSSLLNALFRIVEVEKGRILIDDCDVGKFGLMDLRKVLGIIPQSPVLFSGTVRFNLDPFG 1341

  Fly  1192 EYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEAT 1256
            |::|..||.|||...||:.:...|.||.::::|.|.|||||||||:.|:||:||.::|||:||||
plant  1342 EHNDADLWESLERAHLKDTIRRNPLGLDAEVSEAGENFSVGQRQLLSLSRALLRRSKILVLDEAT 1406

  Fly  1257 ANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKV 1321
            |.||.:||.|||.|||.:||.||:|.|||||:||:|.||:||:|:||..||.:|..||:...|.
plant  1407 AAVDVRTDALIQKTIREEFKSCTMLIIAHRLNTIIDCDKILVLDSGRVQEFSSPENLLSNEGSS- 1470

  Fly  1322 FHGMVKQTGHATYESL--LKIAQKAFENRQNH 1351
            |..||:.||.|..|.|  |.:..|..::..:|
plant  1471 FSKMVQSTGAANAEYLRSLVLDNKRAKDDSHH 1502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	478/1357 (35%)
		ABC_membrane	107..360	CDD:294371	72/264 (27%)
		ABCC_MRP_domain1	445..645	CDD:213217	94/200 (47%)
		ABC_membrane	815..1014	CDD:294371	68/209 (33%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	128/221 (58%)
ABCC2	NP_001189675.1	PLN03130	1..1623	CDD:215595	491/1397 (35%)
		ABC_membrane	309..570	CDD:279056	73/270 (27%)
		ABCC_MRP_domain1	614..815	CDD:213217	94/200 (47%)
		ABC_membrane	925..1179	CDD:294371	83/284 (29%)
		ABCC_MRP_domain2	1240..1460	CDD:213211	128/221 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720