DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and Abcc6

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	NP_112275.1	Gene:	Abcc6 / 81642	RGDID:	620268	Length:	1502	Species:	Rattus norvegicus

Alignment Length:	1394	Identity:	421/1394 - (30%)
Similarity:	680/1394 - (48%)	Gaps:	175/1394 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWE----------- 66
            |....:|.|.|.||:......||.::.|..|||:...:|:.||.|.::|...|.
  Rat   210 PEAEASFPSKAMFWWASGLLWKGYRKLLGPKDLWSLERENSSEELVSQLEREWRRNFSELPGHKG 274

  Fly    67 ------------LELEKTKGKPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYY 119
                        |:.|:::..| ||||:.|||...| |||.:..::....|...|    ||::.:
  Rat   275 HSGMGTPETEAFLQPERSQRGP-LLRAIWRVFRSTF-LLGTLSLVISDAFRFAVP----KLLSLF 333

  Fly   120 THGSESIESA----YYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSA 180
            ......:||:    :..|..:.|.:.|..:....||.....:.:::|..:..::|||.|.||..:
  Rat   334 LEFMGDLESSAWTGWLLAVLMFLSACLQTLFEQQYMYRVKVLQMRLRTAITGLVYRKVLVLSSGS 398

  Fly   181 LGDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPL 245
            ...:.||.||||:|.||.||..:.:.::.||:..|..:.....:::.:|.:|:..||..|..:||
  Rat   399 RKSSAAGDVVNLVSVDVQRLVESILHLNGLWLLFLWIIVCFVYLWQLLGPSALTAVAVFLSLLPL 463

  Fly   246 QAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSY 310
            ..::.|:.|..:.....:...|.|:.:.::..::.||.:.||..|...:...|.:|:.|::..::
  Rat   464 NFFITKKRSFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWECAFLERLLHIRGQELGALKTSAF 528

  Fly   311 IRGI-LLSFIIFLTRVSIFL-SLVGY-----VLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGI 368
            :..: |:||     :||.|| :||.:     |.....:..|.||:.....:||.... .|.|..:
  Rat   529 LFSVSLVSF-----QVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQ-AFLPFSV 587

  Fly   369 SQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIAT 433
            ..:.:..||..|:..::..:|.:...|                              :|.|...:
  Rat   588 HCLVQARVSFDRLAAFLCLEEVDPNGM------------------------------VLSPSRCS 622

  Fly   434 VNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELP 498
                   |:..|||......|...||. .|:|:||.|..|.:|.:||..|:|||||:.|:||||.
  Rat   623 -------SKDRISIHNGTFAWSQESPP-CLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELL 679

  Fly   499 AESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIV 563
            ...|.:.:.||::|..||.|:.:.:|.:|:.|.|.:|.....:|::.|||..|....|....|.|
  Rat   680 KVEGSVSIEGSVAYVPQEAWVQNTSVVENVCFRQELDLPWLQEVLEACALGSDVASFPAGVHTPV 744

  Fly   564 GERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCM--RGYLRERIVILAT 626
            ||:|.:||||||.|:||||||||..::||:||||:|:|.||::.:|:|.:  .|.|:....||.|
  Rat   745 GEQGMNLSGGQKQRLSLARAVYRRAAVYLMDDPLAALDAHVSQEVFKQVIGPSGLLQGTTRILVT 809

  Fly   627 HQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLDFASML---ADPERDEQSEERSRSRS---GS 685
            |.|..|..||||:::..|.::.:|:|:.|.........:|   ..|..:.:.|..:.:.|   |.
  Rat   810 HTLHVLPQADQILVLANGTIAEMGSYQDLLHRNGALVGLLDGARQPAGEGEGEAHAAATSDDLGG 874

  Fly   686 YTHSHSDQRR---------------NSEQSLLSMADSCMDDLEAEQAN-NQERQEAGQIGLRLYS 734
            ::...:..||               .||..:    :..:||:|..... .::..:.|::....|.
  Rat   875 FSGGGTPTRRPERPRPSDAAPVKGSTSEAQM----EPSLDDVEVTGLTAGEDSVQYGRVKSATYL 935

  Fly   735 KYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTW 799
            .|.:|.|.....:.:  |..|.|.:||   :...||                         ||.|
  Rat   936 SYLRAVGTPLCTYTL--FLFLCQQVAS---FCQGYW-------------------------LSLW 970

  Fly   800 LRDIGLSVDAEMLDT----YIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMY 860
            ..|  ..||.:.:.:    .||.::..|..:...|.....|....:||..|..|:...:.|:.:.
  Rat   971 ADD--PVVDGKQMHSALRGSIFGLLGCLQAIGLFASMAAVFLGGARASCLLFRSLLWDVARSPIG 1033

  Fly   861 FFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFY 925
            ||...|.|.:||||||:...||..:|..|..::.....|..:.:.:::..||.::..:.|.:::.
  Rat  1034 FFERTPVGNLLNRFSKETDIVDVDIPDKMRTLLTYAFGLLEVGLAVSMATPLAIVAILPLMLLYA 1098

  Fly   926 QLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMF 990
            ..::.|:.|...::|:|:.:.|.|.||||.:..|...:|||.||....|:.|...|.:....:..
  Rat  1099 GFQSLYVATCCQLRRLESASYSSVCSHLAETFQGSQVVRAFQAQGPFTAQHDALMDENQRISFPR 1163

  Fly   991 ISTSRAFGYWLDC----------FCVIYIAIITLSFFIFPPANGGDVGLAITQAMGMTGMVQWGM 1045
            :...|    ||..          |.....|:::.:..     :.|..|.:::.|:.:|..:||.:
  Rat  1164 LVADR----WLAANLELLGNGLVFVAATCAVLSKAHL-----SAGLAGFSVSAALQVTQTLQWVV 1219

  Fly  1046 RQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPD-PKSENV 1109
            |...:|||:|.|||||.:|.....|.....|:....| .||..|:|.|.:..||:.|: |.:
  Rat  1220 RSWTDLENSMVAVERVQDYVHTPKEAPWRLPSSAAQP-LWPCGGQIEFRDFGLRHRPELPMA--- 1280

  Fly  1110 LKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIP 1173
            ::.:|..|...||||||||||||||||...|.|| ...:|.:.||....::||||.|||:|:|||
  Rat  1281 VQGVSLKIHAGEKVGIVGRTGAGKSSLTWGLLRLQEATEGGIWIDGVPITDMGLHTLRSRITIIP 1345

  Fly  1174 QEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVC 1238
            |:||||.|::|.|||...|.:|:.:|.:||.|:||..|..||..||.:.:..|.:.||||:||:|
  Rat  1346 QDPVLFPGSLRMNLDLLQENTDEGIWAALETVQLKAFVTSLPGQLQYECSGQGDDLSVGQKQLLC 1410

  Fly  1239 LARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGR 1303
            ||||:||:.:||::|||||:|||.|:..:|..:...|.:||||.|||||.::|:..:|||||.|:
  Rat  1411 LARALLRKTQILILDEATASVDPGTEIQMQAALERWFAQCTVLLIAHRLRSVMNCARVLVMDEGQ 1475

  Fly  1304 AVEFGTPYELLTLADSKVFHGMVKQTGHA 1332
            ..|.|:|.:|  ||...:|:.:.:::|.|
  Rat  1476 VAESGSPAQL--LAQKGLFYRLAQESGLA 1502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	416/1375 (30%)
		ABC_membrane	107..360	CDD:294371	65/263 (25%)
		ABCC_MRP_domain1	445..645	CDD:213217	88/201 (44%)
		ABC_membrane	815..1014	CDD:294371	52/208 (25%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	110/222 (50%)
Abcc6	NP_112275.1	MRP_assoc_pro	36..1501	CDD:188098	419/1391 (30%)
		ABC_membrane	313..577	CDD:294371	65/272 (24%)
		ABCC_MRP_domain1	627..828	CDD:213217	88/201 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..909		8/58 (14%)
		ABC_membrane	950..1215	CDD:294371	69/305 (23%)
		ABCC_MRP_domain2	1262..1482	CDD:213211	110/222 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345093
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650