DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7627 and ABCC8

DIOPT Version :9

Sequence 1:NP_001245943.1 Gene:CG7627 / 34148 FlyBaseID:FBgn0032026 Length:1355 Species:Drosophila melanogaster
Sequence 2:XP_016873686.1 Gene:ABCC8 / 6833 HGNCID:59 Length:1604 Species:Homo sapiens


Alignment Length:1442 Identity:447/1442 - (30%)
Similarity:732/1442 - (50%) Gaps:195/1442 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 NFISAACFWYTMPTFIK-GRKRTLDTKDL------YRALKEHKSETLGNKLCASWELELEK---- 71
            |.:|...:|: |..||| ..|:.:|.:.:      .|||..::      :||.:::.::.|    
Human   223 NLLSKGTYWW-MNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQ------RLCEAFDAQVRKDIQG 280

  Fly    72 TKGKPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLI------------------AY 118
            |:|...:.:||...||....|......|.:| |....|:.:..::                  .|
Human   281 TQGARAIWQALSHAFGRRLVLSSTFRILADL-LGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVY 344

  Fly   119 YTHGSESIESAYYYAAGVILCSALNVIIMHPYMLGTMHV----GLKMRVGMCSMIYRKALRLSKS 179
            :....|.:.:||..|  |:|..||  ::...::..:.:|    |:.:|..:.:.||.|.:.||.|
Human   345 FVSSQEFLANAYVLA--VLLFLAL--LLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTS 405

  Fly   180 --ALGDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLF 242
              ::|:.|||.:.||::.|..:|.........||..|::.:....|:|..:|::|:.|.|.::|.
Human   406 NLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILL 470

  Fly   243 IPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRH 307
            .|:|.::..:.|..:..|...::||::..||::.||:::|:||||..|...|...|:||:.::| 
Human   471 APVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLR- 534

  Fly   308 VSYIRGILLSFIIFLTRVSIFLSL---VGYVLLGTFL-----------TPEVAFLITAYYNILRT 358
                     :|.|: |.:|||::.   :..||: ||:           :|.|||...:.::||.|
Human   535 ---------AFAIY-TSISIFMNTAIPIAAVLI-TFVGHVSFFKEADFSPSVAFASLSLFHILVT 588

  Fly   359 TMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMDMSV-DLTEDFQGSNQETV-------HADG 415
            .: ......:....:.|||::::.:::.|.|......:. :.|.....|..:.|       |:..
Human   589 PL-FLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVEEGLPSLHSSQ 652

  Fly   416 ----------------DEERDEAED--KLLGPPIATV-NENAKLSEAGISISGLMAKWDVNSPD- 460
                            :.:|...||  .|.||..:.| :.:.......:.|.|....|   :|| 
Human   653 PSGSSPPNHPQPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTW---TPDG 714

  Fly   461 -YSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESG---------------------- 502
             .:|:.:.:|:..|.:..|||:.|.|||||:.|.|||:...||                      
Human   715 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSSLPDSEIGEDPSPERE 779

  Fly   503 -----EIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTI 562
                 :|:..|.::||||:|||.:.||.:||:|..|.:::||..|::.|:|:.|.::||..|:|.
Human   780 TATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQ 844

  Fly   563 VGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRE--RIVILA 625
            :||||.:|||||:.|||:|||:|:..::..||||.||:|.|::.||.:..:...||:  |.|:|.
Human   845 IGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLV 909

  Fly   626 THQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLD-FASMLADPERDEQSEERSRSRSGSYTHS 689
            ||:||:|.|||.|:.|..|.:...||.:..:.|... |........|.:|..|:.     :.|..
Human   910 THKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKE-----TVTER 969

  Fly   690 HSDQRRNSEQSLLSMADSCMDDLEAEQANNQERQE----------AGQIGLRLYSKYFKAGGGFF 744
            .:.:........:|..|..:.|.|.|:....|.:|          ..:|..|..:||..:.|   
Human   970 KATEPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAG--- 1031

  Fly   745 AFFVMMGFCVLSQGLASLGDYFLSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDA 809
              .:::...|.||.|..:....:.||:.|..:.|.               .|:...|:..||.:.
Human  1032 --ILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSAL---------------TLTPAARNCSLSQEC 1079

  Fly   810 EMLDT---YIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRIL 871
            .:..|   .:|||:..|.|::.:..|.......:|.:.|||.|:...|..|.|.||.|.|.|.||
Human  1080 TLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSIL 1144

  Fly   872 NRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSR 936
            ||||.|...:|:.:|:.:..:.:..|.....:.||:.|.|:||:..:.|.|:.|.::.::...||
Human  1145 NRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASR 1209

  Fly   937 DVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWL 1001
            |:::::..|:.|:.||.|.::.||:|||||..:...:.:...|.|.::.|.....:.:|    ||
Human  1210 DLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANR----WL 1270

  Fly  1002 DC------FCVIYIAIIT-LSFFIFPPANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVE 1059
            :.      .||:.||.:| :|..:....:.|.|||.:|.|:.::..:.|.:|..|::|..:.||:
Human  1271 EVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVK 1335

  Fly  1060 RV---VEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKE 1121
            |:   ::.|....||.|   |....||:||:||||....||:||  |...:.|||.::.:|.|.:
Human  1336 RIHGLLKTEAESYEGLL---APSLIPKNWPDQGKIQIQNLSVRY--DSSLKPVLKHVNALIAPGQ 1395

  Fly  1122 KVGIVGRTGAGKSSLINALFRL-SYNDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRY 1185
            |:||.||||:||||...|.||: ...:|.::||..|.:::.||.|||::|||.|:|||||||:|:
Human  1396 KIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRF 1460

  Fly  1186 NLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQLVCLARAILRENRIL 1250
            ||||..:.||..||.:||..:||.||..||.||.:.|||||.|||.|||||.|||||.:|:..|.
Human  1461 NLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIF 1525

  Fly  1251 VMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLT 1315
            :||||||::|..|:.::|..:...|.:.||:|||||:|||:.:|.|:|:..|..:||..|.:||:
Human  1526 IMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLS 1590

  Fly  1316 LADSKVFHGMVK 1327
            ..|| ||...|:
Human  1591 RKDS-VFASFVR 1601

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7627NP_001245943.1 CFTR_protein 12..1315 CDD:273530 441/1428 (31%)
ABC_membrane 107..360 CDD:294371 75/290 (26%)
ABCC_MRP_domain1 445..645 CDD:213217 89/230 (39%)
ABC_membrane 815..1014 CDD:294371 64/205 (31%)
ABCC_MRP_domain2 1089..1310 CDD:213211 112/221 (51%)
ABCC8XP_016873686.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151569
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.650

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