DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7627 and abcc12

DIOPT Version :9

Sequence 1:NP_001245943.1 Gene:CG7627 / 34148 FlyBaseID:FBgn0032026 Length:1355 Species:Drosophila melanogaster
Sequence 2:XP_009301629.1 Gene:abcc12 / 568482 ZFINID:ZDB-GENE-050517-25 Length:1368 Species:Danio rerio


Alignment Length:1408 Identity:472/1408 - (33%)
Similarity:763/1408 - (54%) Gaps:160/1408 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 QSLKTADLP------ENPREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETL-GN 59
            |||||. :|      .:|.:...|.|...|.:..|...:..:..||...|:  |..|....: |.
Zfish    52 QSLKTL-IPFRFASNSHPVDDAGFFSFTSFSWMTPMMWRLFRNRLDEDSLF--LSPHDGAHINGE 113

  Fly    60 KLCASWELELEKTKGKPNLLRALLRVF---GWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYTH 121
            :....|:.|:.:...:...|.|::..|   .:..:.|..|:|...:   .:.|..|:..|..|..
Zfish   114 RFQRLWDEEVARVGLEKASLSAVIMRFQKTRFIVSFLASVMFAFAV---FVGPSILVYEILNYVE 175

  Fly   122 GSESIESAYYYAAGVILCSALNVI----IMHPYMLGTMHVGLKMRV-GMCSMIYRKALRLSKSAL 181
            .||  .|...:..||  |.||.:.    .....:|..:::...:|| |..||:..|.: :|..:|
Zfish   176 QSE--PSTVVHGVGV--CVALFLTEFSKAFFASVLWAVNLRTAVRVKGAFSMLAFKKI-ISLRSL 235

  Fly   182 GDTTAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYR--EIGIAAVFGVAFMLLFIP 244
            ...|.|..:|::::|..||..|.||..:|...|:  |.|..::|.  .:|..|:.|:...|:|:|
Zfish   236 TTITVGETINVLTSDGYRLFDAVIFGTFLLCVPV--LLIICIIYACFILGYTALIGILVYLIFLP 298

  Fly   245 LQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVS 309
            :|..:.:...|.|.|....||:|||.|||:::.|::|||||||..||..:...||.|...::...
Zfish   299 IQFSIARLIGVFRRRAVSVTDKRVRTMNEVLTCIKLIKMYAWEESFEKSITDIRKNEKLLLQKAG 363

  Fly   310 YIRGILLSFIIFLTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAET 374
            |::.:..|....:..::..::.:.:..|...|.|..|:.|.|.:|.:|.:|.: .|..:..:||.
Zfish   364 YVQSLNSSLTTIVPTLATIVTFIVHTSLKLPLLPSTAYTIIAVFNCMRMSMGL-LPFSVKAVAEA 427

  Fly   375 LVSIKRVQKYMQSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAK 439
            .|::.|:::.|             |.::.:|      :...|:..|          :|.|.|.|.
Zfish   428 KVALTRLKRIM-------------LVQNPKG------YLTQDKNMD----------LALVMEKAT 463

  Fly   440 LSEAGISISGLMAKW----DVNSPDY----------------SLNGVNLRVQPGTMLGIVGRTGS 484
            .|            |    |.|:...                ||..::|.:..|::||:.|..||
Zfish   464 FS------------WSPTDDKNTSQMPENPSQNGKHKAESQPSLRNISLTLSKGSLLGVCGNVGS 516

  Fly   485 GKSSLIQAILGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALE 549
            ||:|||.:||.::...||.:..||:::|.||:.|:|.||||.|||.|:|.|..|||.|:..|.|:
Zfish   517 GKTSLISSILEQMHLLSGSVSANGTLAYVSQQAWIFHGTVRDNILMGEPFDEARYASVINACCLK 581

  Fly   550 RDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMR 614
            .|..:||:.|:|.:||||.:||||||.|:|||||||....|:||||||||||.||.:|:||:|::
Zfish   582 PDLAILPYGDQTEIGERGINLSGGQKQRVSLARAVYSNRDIFLLDDPLSAVDAHVGKHIFEECIK 646

  Fly   615 GYLRERIVILATHQLQFLQHADQIVIMDKGRVSAVGTYESLRESGLDFASMLADPERDEQSEERS 679
            ..|:.:.|||.|||||:|:..|:::::|.|.:...||:..|.::...::.::.:... ||:.||:
Zfish   647 KELKGKSVILVTHQLQYLEFCDEVMLLDNGEIKEAGTHSDLMKTKGRYSQLITNVHL-EQNNERA 710

  Fly   680 RSRSGSYTHSHSDQRRNSEQSLLSMADSCMDDLEAEQANNQ------------------ERQEAG 726
            .|:..: .|:.|:|....|.....:.:...|..:.:.|.|:                  |..:.|
Zfish   711 DSKPQT-EHNDSEQTNPDEPKANGIENPAFDMSDEKPATNETPKDSSETKGKKDQLVTREVAQEG 774

  Fly   727 QIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTK-KGNVAYRADNNDTTRSE 790
            .:..|.|.:|.:|.||:...|:::....|..|..:..:::||||:.: .||   .:.:|.|:.|.
Zfish   775 SVTWRTYHQYCQAAGGYILLFLVVLLFTLLVGSTAFSNWWLSYWLDQGSGN---NSSSNATSNSG 836

  Fly   791 EL--EPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFLFFNLAMKASIRLHNSMFRG 853
            .:  .|.||.:              ..::.||.:..|::::.:.:.|..:.:::|.:||::||:.
Zfish   837 NISENPDLSFY--------------QMVYGVIIIAMIVLSILKGYTFTKVTLRSSSKLHDTMFKR 887

  Fly   854 ITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTV 918
            |..:.|.||:|.|:||::||||||..:||.:||..|.:.:|..|.:...::.|.:|.|..||..|
Zfish   888 ILGSPMSFFDTTPTGRLVNRFSKDQDEVDAVLPFNMENFLQFCLIVTFTLLTICIVFPFLLIAVV 952

  Fly   919 VLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMH 983
            :||:||..:...:.::.|.:||||.::|||..|...:::.|||||.|:..::.....|....|.:
Zfish   953 ILGLIFATILYVFQRSIRHMKRMENVSRSPWISLTTSTIQGLSTIHAYDKRQQYIERFKMLSDNN 1017

  Fly   984 SSAFYMFISTSRAFGYWLDCFCVIYIAIITLSFFIFPP---ANGGDVGLAITQAMGMTGMVQWGM 1045
            |:.|.:|.:.:|...:|||........|::| |.:..|   .|....|||::..:.:||::|:.:
Zfish  1018 SNHFMLFNAGTRWLSFWLDVLSATVTLIVSL-FVVLSPNETINPSLKGLALSYTIQLTGILQFVV 1081

  Fly  1046 RQSAELENTMTAVERVVEY-EDIEPEGALEAPADKKPPKSWPEQGKIVFDELSLRY---TPDPKS 1106
            |.|.|:|...|:|||::|| .....||.... .|...|..||::|.|.|...|:||   ||    
Zfish  1082 RLSTEVEAKFTSVERLLEYITSCVSEGPRRV-KDANIPAGWPQEGTITFKNYSMRYRDNTP---- 1141

  Fly  1107 ENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSY-NDGSVLIDKRDTSEMGLHDLRSKIS 1170
             .||.:|:..|:|.||:|||||||:|||||..|||||:. .:|::|||..|..::||.||||::|
Zfish  1142 -IVLDNLNITIRPGEKLGIVGRTGSGKSSLGVALFRLAEPAEGTILIDDMDICKLGLKDLRSQLS 1205

  Fly  1171 IIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFSVGQRQ 1235
            :|||:||||.||:|||||||:.|.|::||.:||:..:|:.::.||..|||.:.|.|.|||||:||
Zfish  1206 VIPQDPVLFIGTVRYNLDPFNNYKDEELWLALEKTYMKDTISKLPEKLQSPVVENGENFSVGERQ 1270

  Fly  1236 LVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAHRLHTIMDSDKVLVMD 1300
            |:|:|||:||.::|:::|||||::|.:||.|||.|||:.|:.||:||||||::|:::||::||||
Zfish  1271 LMCMARALLRNSKIILLDEATASIDSETDSLIQHTIRDGFQHCTMLTIAHRINTVLESDRILVMD 1335

  Fly  1301 AGRAVEFGTPYELLTLADSKVFHGMVKQTGHATYESLLKIAQK 1343
            .|:.:||..|.:|:             |..::.:.|||..|.:
Zfish  1336 QGKVIEFDPPQDLI-------------QRPNSLFASLLAAANQ 1365

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7627NP_001245943.1 CFTR_protein 12..1315 CDD:273530 461/1362 (34%)
ABC_membrane 107..360 CDD:294371 76/259 (29%)
ABCC_MRP_domain1 445..645 CDD:213217 96/219 (44%)
ABC_membrane 815..1014 CDD:294371 65/198 (33%)
ABCC_MRP_domain2 1089..1310 CDD:213211 122/224 (54%)
abcc12XP_009301629.1 CFTR_protein 68..1366 CDD:273530 466/1391 (34%)
ABC_membrane 149..414 CDD:294371 79/274 (29%)
ABCC_MRP_domain1 457..677 CDD:213217 100/231 (43%)
ABC_membrane 809..1077 CDD:294371 86/285 (30%)
ABCC_MRP_domain2 1125..1345 CDD:213211 122/224 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170586092
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
76.660

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