DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7627 and AgaP_AGAP006380

DIOPT Version :9

Sequence 1:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster
Sequence 2:	XP_001688862.1	Gene:	AgaP_AGAP006380 / 5666864	VectorBaseID:	AGAP006380	Length:	1652	Species:	Anopheles gambiae

Alignment Length:	1475	Identity:	282/1475 - (19%)
Similarity:	490/1475 - (33%)	Gaps:	523/1475 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 LRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYTHGSESIESAYYYAAGVILCSALN 143
            |.||:.|..:::..:..|.::.....:.|:....:..::.:.|.     ||::....::|..:|:
Mosquito   253 LLALIIVISFFYTCINTVKYITIEKEKQLKEAMKIMGLSNWLHW-----SAWFVKCLILLTVSLS 312

  Fly   144 VI------------------------IMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDT 184
            :|                        ....|.:.|        :..|.||   ::..||:    .
Mosquito   313 LITILLCVPFSSAAIFENSDWTLIWVFFFVYSIST--------ICFCFMI---SVFFSKA----N 362

  Fly   185 TAGHVVNLMSNDVGRLDLATIFVHYLWVGPLETLFITYL-------MYREIGIAAVFGVAF---- 238
            ||..:..|                 ||       |:|.|       .|.|:|..|..|:..
Mosquito   363 TAAGIAGL-----------------LW-------FVTQLPFNVSQQNYDEMGTGAKLGMCLLSNS 403

  Fly   239 -----MLLFIPLQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFAR 298
                 |.|.:.|:|            ||:              |::      |...||...
Mosquito   404 GMSLAMFLTVRLEA------------TAV--------------GLR------WSNLFEPAT---- 432

  Fly   299 KKEINAIRHVSYIRGILLSFIIFLTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVF 363
                           |...|.:.|..:.:.:..|.|:|:..::..    ::...:.|.|..   :
Mosquito   433 ---------------IDDGFNVGLIIIMLLVDAVIYLLIALYIEQ----IMPGEFGIARPW---Y 475

  Fly   364 FPQGISQMAETLVSIKRVQKYMQSDETNVMDMSVDLTEDF----QGSNQETV-HADGDEERDEAE 423
            ||                                 .|::|    |..:::|: .|:|..|....|
Mosquito   476 FP---------------------------------FTKEFWVRTQTPSRDTLFQANGSTESRYIE 507

  Fly   424 DKLLGPPIATVNENAKLSEAGISISGLMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSS 488
            ....|             .||:.|..|...:..|..  :::|:|||:....:..::|..|:||::
Mosquito   508 QDPAG-------------YAGVEIKQLRKVYKGNKA--AVDGLNLRMYENQISVLLGHNGAGKTT 557

  Fly   489 LIQAILGELPAESGEIKVNG------------SMSYASQEPWLFSG-TVRQNILF-----GQPMD 535
            .:..:.|.....||...:||            |:....|...||.. ||.:::.|     |.|.:
Mosquito   558 TMSMLTGVFAPTSGTALINGHDIRTDIDGVRSSLGLCPQHNVLFDEMTVDEHLKFFSRLKGVPTE 622

  Fly   536 RRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRETSIYLLDDPLSAV 600
                   .....::|..:||...||.  ..:..:||||.|.::::..|:...:.:.|||:|.|.:
Mosquito   623 -------AVSGEIDRYLKLLELTDKR--DAQSQTLSGGMKRKLAVGMALCGGSKVVLLDEPTSGM 678

  Fly   601 DTHVARHLFEQCMRGYLRERIVILATHQLQFLQHA----DQIVIMDKGRVSAVG----------- 650
            |....|.|: ..::...:.|.::|:||   |:..|    |:|.||.:|::.|||
Mosquito   679 DPSARRALW-NLLQKEKQNRTMLLSTH---FMDEADVLGDRIAIMAEGKLKAVGSPFFLKKTFGV 739

  Fly   651 ----------------------------TYES---------LRESGLD-FASMLADPERDEQS-- 675
                                        |.::         |:|..|| |..:|.|.|:...|
Mosquito   740 GYRLICVKDARCDKQRLLGILRKYIPDVTIDTDIGSELSFILKEDYLDVFQRLLEDIEQQMVSCG 804

  Fly   676 -----------EE-------RSRSRSGSYTHSHSDQRRNSEQS-----LLSMADSCMDDLEAEQA 717
                       ||       .|...:|::|:....:..:||.:     ||:..:...:.::|:
Mosquito   805 ITSYGISLTTMEEVFLKAGSDSFDETGTHTNGTVVETGSSEYALDRLHLLTGKELLFNQIQAQ-- 867

  Fly   718 NNQERQEAGQIGLRLYSKYFKAGGGFF---------AFFVMMGFCV---LSQG--LASLGDYFLS 768
                          |..||..:...:.         .|||.|.|.:   :|.|  |.:|.....|
Mosquito   868 --------------LLKKYLSSIRAWVQLVMMFVIPIFFVCMTFIITRSISAGKDLPALEITIDS 918

  Fly   769 YWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIG--LSVDAEM--------------LDTYIF 817
            |  .|...|..|| ..:|.|.|..:    ....|.|  :::|.:|              ::|..|
Mosquito   919 Y--EKAITVLERA-GGETARVEAFQ----NMFTDRGELVTIDEDMTEYIVRKSIEDIAAVNTRYF 976

  Fly   818 TVITVLTILVTVA----RSF----LFFNLAMKASI-------RLH--------------NSMFRG 853
            ...|:.:....|.    ::|    |..||...|.:       :||              ..:..|
Mosquito   977 VGATIRSGAPYVGWFNNKAFHTAPLALNLVYSAILQAQCTECQLHVINKPLPYRLDTQLKKLNTG 1041

  Fly   854 ITRAAMYFFNTN-----PSGRILNRFSKDMGQVDEILPAVMMDVIQIFLALAGI-VIVIAVVNPL 912
            :.......|||.     .:...:..:.|:.....::|..|....:.:|..||.: ...:.|:|.|
Mosquito  1042 LNAGFQLAFNTGFAMAFVAALYIMFYIKERTSRAKLLQFVSGTNVTMFWLLAFMWDFTLFVLNSL 1106

  Fly   913 FLIPTVV------------LGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHL-AASLTG----- 959
            ..|.||.            ||..|..|..|...|         :..:.::|.| :.|.||
Mosquito  1107 VYIATVAIFQEEGWSTFEELGRAFLLLLFFGYAT---------LPVTYLFSFLFSVSATGFVRMM 1162

  Fly   960 ----LSTIRAFGAQRVLEAE-----------------FDNYQDMHS----SAFYMFISTSRAFGY 999
                ||....|.|..||:.:                 |.|:...|.    :|.....|:.:.|..
Mosquito  1163 FVNVLSGAIFFTAVNVLKFDGIDLVEVAEGLEWVFMFFPNFVLSHGLNNLNAASSTASSCKKFCD 1227

  Fly  1000 WL------DCFCVIYIAIITLSFFIFPPANGGDVG---------LAITQAMGMTGMVQWGMRQSA 1049
            .|      |..|.:......|..|.|     |:||         |..|.:..:..|:::|:
Mosquito  1228 LLGAQCVVDDLCSVDARCCDLEVFSF-----GNVGIIRNLLFCVLIGTVSFSLLFMLEYGV---- 1283

  Fly  1050 ELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSWPEQGKIVFDE----LSLRYTPDPKSENVL 1110
                    ::|:.:.   :|:|: .:||..:.... .||...|.:|    .:|..| |....|:|
Mosquito  1284 --------LQRLFQR---KPKGS-ASPAGPQGTVG-SEQDSDVLEEKRRIANLSRT-DIDGHNLL 1334

  Fly  1111 --------------KSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSVLIDKRDTSEMG 1161
                          .:||..|...|..|::|..||||::    .|::...|..:.........:.
Mosquito  1335 LRDVTKYYGNFQAVNNLSIGINHSECFGLLGINGAGKTT----TFKMMTGDEEISSGNAWVKGIS 1395

  Fly  1162 LHD----LRSKISIIPQ-EPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQ-- 1219
            |.:    ...:|...|| :.:|...|.|..|..|      .|.|.:.:.::|.|...|...|.
Mosquito  1396 LREDMNRAHRQIGYCPQFDALLEDLTGRETLRIF------ALLRGVRKQEVKNVSYILAEELNFT 1454

  Fly  1220 ---SKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDP 1261
               .|.|:.   :|.|.::.:..|.|:|....::.:||.|..:||
Mosquito  1455 KHLDKRTKA---YSGGNKRKLSTALALLGNPSVVYLDEPTTGMDP 1496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	282/1475 (19%)
		ABC_membrane	107..360	CDD:294371	45/292 (15%)
		ABCC_MRP_domain1	445..645	CDD:213217	54/221 (24%)
		ABC_membrane	815..1014	CDD:294371	52/282 (18%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	46/201 (23%)
AgaP_AGAP006380	XP_001688862.1	ABC2_membrane_3	<257..459	CDD:289468	45/296 (15%)
		CcmA	516..796	CDD:224054	65/294 (22%)
		ABC_subfamily_A	516..734	CDD:213230	58/232 (25%)
		ABC2_membrane_3	879..1213	CDD:289468	69/349 (20%)
		ABC_subfamily_A	1333..1551	CDD:213230	40/177 (23%)
		drrA	1340..1645	CDD:130256	39/170 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910